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Necitumumab is available as a 800 mg/50 mL (16 mg/mL) injection for IV use.

Necitumumab is an epidermal growth factor receptor (EGFR)
antagonist indicated, in combination with gemcitabine and cisplatin, for first-line treatment of patients with metastatic squamous non-small cell lung cancer.

Necitumumab is a targeted anticancer medication used to treat non-small cell lung cancer (NSCLC). It blocks a protein called the epidermal growth factor receptor (EGFR). Sometimes, EGFR sends signals to cancer cells that tell them to grow. So when we block this receptor with Necitumumab, cancer cells can’t grow and spread as well. This medication is given with chemotherapy for up to 4 months. After that, your provider might continue treatment with Necitumumab by itself as long as it’s working and you’re not experiencing any serious side effects.

Necitumumab is given intravenously at a provider’s office or infusion center. A healthcare provider will infuse the medication either through your arm or another access device, like a port. It’s usually given with chemotherapy once a week for two weeks, then you take a one week break. Typically, you’ll receive Necitumumab with chemotherapy for up to 4 months. After that, your provider will stop the chemotherapy and might continue to treat you with Necitumumab by itself depending on how this medication has been working for you.

Necitumumab is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Necitumumab:

• Rash
• Low magnesium levels

Serious side effects are rare with Necitumumab.
There are two black box warnings for Necitumumab. The first is a risk of cardiac arrest and sudden death, which might be related to changes in blood levels of electrolytes like magnesium, potassium, and calcium. The second warning is specifically about low magnesium levels in the blood, which if severe enough, can lead to life-threatening heart rhythm problems.

There are no major drug interactions listed for Necitumumab. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Various FDA-approved generic manufacturers

Based on animal data and its mechanism of action, Necitumumab can cause fetal harm when administered to a pregnant woman. If you can become pregnant you should use effective contraception during treatment with Necitumumab and for three months following the final dose.

• Portrazza