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Naratriptan is available as 1 mg and 2.5 mg tablet.

Naratriptan is a serotonin (5-HT 1B/1D ) receptor agonist (triptan) indicated for
the acute treatment of migraine with or without aura in adults.

Naratriptan is a triptan. It works on receptors in your brain and nervous system that respond to serotonin, a natural chemical in your body that’s thought to play a role in migraines.

When it attaches to the serotonin receptors in the brain, Naratriptan tightens the blood vessels in the brain and lessens blood vessel swelling that can cause migraine pain. The medication also stops the release of other pain signals through your nervous system. This helps relieve migraine pain.

Naratriptan is typically taken as 1 mg or 2.5 mg by mouth once as a single dose for migraine pain. You can take another dose 4 hours after the first dose if your migraine does not go away. You should not take more than 5 mg in a day.
Your dose might differ if you have kidney or liver damage.

Naratriptan is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take Naratriptan if you have a history of coronary artery disease or coronary artery vasospasm, Wolff-Parkinson-White syndrome or other cardiac accessory conduction pathway disorders, history of stroke, transient ischemic attack, or hemiplegic or basilar migraine, peripheral vascular disease, ischemic bowel disease, uncontrolled hypertension, recent (within 24 hours) use of another 5-HT 1 agonist (e.g., another triptan) or an ergotamine-containing medication, or severe liver or kidney impairment.

Common side effects of Naratriptan include:

• Dizziness
• Drowsiness
• Fatigue
• Paresthesias
• Pain/pressure sensation
• Nausea

Serious side effects are rare with Naratriptan. Contact your healthcare provider immediately if you experience any of the following.

• Heart problems: heart attack, dangerously high blood pressure, severe headache, chest pain, trouble breathing, irregular heartbeat
• Stroke: sudden weakness on one side of your body, severe headache, changes in your speech or vision, confusion
• Narrowing of blood vessels in the body: bloody diarrhea; severe stomach pain; partial or permanent blindness; vision problems; tightness,
• weakness, numbness of legs or feet
• Serotonin syndrome: fast heart rate, dizziness, sweating, flushing, tremor (shakiness), muscle stiffness or twitching, uncoordinated movement, hallucinations

The following medications may interact with Naratriptan:

• Ergot-containing drugs and other triptans – There have been reports of prolonged vasospastic reactions and they should not be used within 24 hours of each other
• Selective serotonin reuptake inhibitors (SSRIs)/serotonin norepinephrine reuptake inhibitors (SNRIs) – Increases your risk of serotonin syndrome

Various FDA-approved generic manufacturers

Naratriptan may cause harm to your unborn baby, based on animal studies. Talk with your healthcare provider about the risks of taking Naratriptan if you become pregnant.

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