Are you tired of high medication costs? Our service offers unbeatable savings on your MYFEMBREE prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.

Manufactured by Sumitomo Pharma

*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.

This content is intended for US audiences only

MYFEMBREE cost saving options available to you

  • Qualified

    Rx Advantage Card

    NowPatient's Rx Advantage card is a simple & convenient way to save money on your MYFEMBREE

    You can save up to 90%

  • Unavailable

    Canadian Prescription Savings

    Manufactured by
    Powered by
    Buy your MYFEMBREE without insurance from Canada at discounts of up to 90% using NowPatient's Canadian Prescription savings program.
  • Available

    Drug Coupons

    Obtain your MYFEMBREE for as little as $0 per fill. Suitable for insured individuals only.

    You can pay as little as $0

  • Available

    Patient Assistance Programs

    Obtain your MYFEMBREE at no cost. Suitable for insured, underinsured and uninsured individuals

    You can receive for FREE


How it works

How to Lower Your Drug Costs

  • swoosh
    View programs

    View the savings programs that are available

  • swoosh
    Select program

    Pick the program that is suitable for you

  • swoosh

    If required, complete the online qualification check

  • swoosh
    Start Saving

    Enroll & Start Saving



Why Choose Our Service?

  • black dot icon

    Comprehensive Coverage

    Our service covers a wide range of medications, ensuring you can find savings on almost any prescription.

  • emoji icon

    Easy to Use

    Our website is user-friendly, allowing you to quickly find and apply discounts.

  • check icon

    Trusted by Many

    Thousands of users trust us to help them save on their medication costs every day.


Start Saving Today!

Lower the cost of your MYFEMBREE prescription

Join the many satisfied customers who have already benefited from our prescription discount service.

Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

MYFEMBREE Uses, Side Effects, Interactions, Warnings & Dosing



MYFEMBREE is the brand name for relugolix, estradiol, and norethindrone acetate and is available as an oral tablet.

What dosages is MYFEMBREE available in?

What dosages is MYFEMBREE available in?

MYFEMBREE is a fixed-dose combination oral tablet containing relugolix 40 mg, estradiol 1 mg and norethindrone acetate 0.5 mg.

What is MYFEMBREE used for?

What is MYFEMBREE used for?

MYFEMBREE is a GnRH antagonist / Estrogen replacement / Progestin and is used to treat the following:

  • Heavy menstrual bleeding related to uterine fibroids in women who haven’t reached menopause
  • Moderate-to-severe pain related to endometriosis in women who haven’t reached menopause
How does MYFEMBREE work?

How does MYFEMBREE work?

MYFEMBREE is a combination of three medications. Relugolix is a gonadotropin-releasing hormone (GnRH) antagonist. GnRH is a natural hormone in the body that plays a role in making estrogen and progesterone hormones. These hormones all play a role in maintaining your reproductive system. Relugolix blocks the actions of GnRH, which lowers the estrogen and progesterone levels in your body. This lessens bleeding that happens with uterine fibroids and pain from endometriosis. Estradiol is an estrogen replacement. It replaces some of the estrogen in your body that’s lost from relugolix. Replacing estrogen might help prevent bone loss. Norethindrone is a progestin (a lab-made form of progesterone). It replaces some of the progesterone in your body that’s lost from relugolix. This might help protect the uterus from damage from the effects of estrogen alone, which might help prevent uterine (endometrial) cancer.

How do I take MYFEMBREE?

How do I take MYFEMBREE?

MYFEMBREE is typically taken as 1 tablet by mouth once a day around the same time each day, with or without food. It’s recommended to take the medication for a maximum of 2 years because of the risk for bone loss.

Is it safe for me to take MYFEMBREE?

Is it safe for me to take MYFEMBREE?

MYFEMBREE is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

  • High risk of arterial, venous thrombotic, or thromboembolic disorder
  • Pregnancy
  • Known osteoporosis
  • Current or history of breast cancer or other hormone-sensitive malignancies
  • Known hepatic impairment or disease
  • Undiagnosed abnormal uterine bleeding
  • Known hypersensitivity to components of MYFEMBREE
MYFEMBREE Common Side Effects

MYFEMBREE Common Side Effects

Common side effects of MYFEMBREE:

  • New or worsening high blood pressure
  • Unusual or irregular vaginal bleeding
  • Hair loss or hair thinning
  • Headache
  • Hot flashes, a lot of sweating, or night sweats
  • Mood problems or mood swings
  • Unusual vaginal bleeding
  • Nausea
MYFEMBREE Serious Side Effects

MYFEMBREE Serious Side Effects

Serious side effects are rare with MYFEMBREE. Contact your healthcare provider immediately if you experience any of the following.

  • Blood clot: swelling or redness in the leg, shortness of breath, chest pain
  • Heart attack: shortness of breath, arm or chest pain, sweating
  • Stroke: slurred speech, vision changes, facial drooping, sudden weakness on one side of the body, sudden headache
  • Liver or gallbladder problems: yellowing of your skin or eyes (jaundice), pain in the upper right part of your stomach, nausea, vomiting, dark urine
  • Uterine fibroid that comes out into the vagina: heavy menstrual bleeding, severe cramping
  • Suicidal thoughts or behavior
  • Serious allergic reaction: swelling in the face, tongue, or throat; trouble breathing; hives
Effects of other drugs, drug classes and over-the-counter products on MYFEMBREE

Effects of other drugs, drug classes and over-the-counter products on MYFEMBREE

The following medications may interact with MYFEMBREE:

  • Avoid use of MYFEMBREE with oral P-gp inhibitors
  • Avoid use with combined P-gp and strong CYP3A inducers, as the exposure of the components of MYFEMBREE may be decreased
Who makes MYFEMBREE?

Who makes MYFEMBREE?

Sumitomo Pharma

Is MYFEMBREE safe in pregnancy?

Is MYFEMBREE safe in pregnancy?

MYFEMBREE is contraindicated in pregnancy. Based on findings from animal studies and its mechanism of action, MYFEMBREE may cause early pregnancy loss. Discontinue MYFEMBREE if pregnancy occurs during treatmentThere is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to MYFEMBREE during pregnancy. Pregnant females exposed to MYFEMBREE and healthcare providers are encouraged to call the MYFEMBREE Pregnancy Exposure Registry at 1-855-428-0707.


What to do if you missed your MYFEMBREE dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
dollar sign

Drug Savings Tips

Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

FAQ logo

Things to know

Now Patient Data Security

Data Security

Our Commitment to You.

Find out moreNow Patient Data SecurityNow Patient Data Security

What is NowPatient

Online Pharmacy & Telehealth

NowPatient is an online pharmacy & telehealth service that is available in the US and UK. Our service is FREE and packed with useful features that can help you save money on the cost of your medications, access virtual treatments, and provide tools that can help improve your overall health.  Get started today and benefit from medication reminders, private treatment plans, NHS online pharmacy, GP appointment booking, Rx savings card, Drug Coupons, US drug savings programs, health conditions information, Drug Information, genetic testing, home test kits, BMI Risks, Type 2 Diabetes Riskspollen meter, air quality monitor, and lots more!

A laptop screen displays a dashboard with various health metrics and notifications. Widgets include drug coupons, home health testing, genetic risk, diabetes risk, BMI, pollen meter, and air quality.


To improve the lives of everyone by making high-quality care accessible and convenient

We are here to improve lives. Our service gives you access to smart features and resources that can help empower you to take control of your health and improve your health outcomes. All this, in one place, for FREE. We strive to bring a fresh perspective to managing health. NowPatient can be accessed by downloading the App or using your web browser.

Download our app today

A collage showing a map with pharmacies, a questionnaire, medication details, and a person video chatting on a screen.

Can I trust NowPatient

Meet our medical team

We are a passionate group of clinicians and medical writers covering a broad range of specialities with experience operating in health systems in the United Kingdom & United States. Providing excellent care and advice is at the heart of everything we do. You can read more about our medical team by visiting the medical team page or learn more about how we curate content by visiting our editorial process

Your Questions Answered

For your peace of mind, we can answer your questions quickly

We have a comprehensive list of FAQ’s on each feature page. Alternatively, for broader questions around our service just click the button below.
Find your answers