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Mvasi is the brand name for bevacizumab-awwb IV infusion.

Mvasi is available as 100 mg/4 mL (25 mg/mL) or 400 mg/16 mL (25 mg/mL) single-dose vial.

Mvasi is a vascular endothelial growth factor (VEGF) inhibitor and is used for the following:

• Metastatic, recurrent, or persistent cervical cancer
• Metastatic colorectal cancer
• Recurrent glioblastoma
• Non-squamous non-small cell lung cancer
• Ovarian, fallopian tube, or primary peritoneal cancer
• Metastatic renal cell carcinoma

Mvasi is a targeted therapy anticancer medication known as a vascular endothelial growth factor (VEGF) inhibitor. VEGF is a specific protein that helps cancer cells grow by promoting and expanding their blood supply. Mvasi works by blocking VEGF. This cuts off cancer’s blood supply, helping slow down its growth.

Mvasi is dosed as follows:

• Mvasi is infused into the veins (IV) by a healthcare provider. Your provider will determine the right dose based on your body weight
• The typical dose of Mvasi ranges from 5 mg/kg to 15 mg/kg infused IV once every 2 to 3 weeks
• Your exact dose and how often you’ll get the infusion also depends on the type of cancer you have and what other anticancer medications your provider prescribes

Mvasi is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Mvasi:

• Nose bleeds
• Headache
• High blood pressure
• Runny nose
• Higher levels of protein in urine test
• Changes in taste
• Dry skin
• Bleeding that’s difficult to stop
• Dry eyes or watery eyes
• Back pain
• Peeling or blistering skin

Serious side effects are rare with Mvasi. Contact your healthcare provider immediately if you experience any of the following.

• Tears in the gut: fever, chills, intense stomach pain or cramps, bloating
• Fistulas: skin irritation around the anus, discharge from the anus, swelling or redness around the anus, blood in the stool
• Serious bleeding (general): unusual bleeding, bleeding that’s difficult to stop, easy bruising, blood in urine or
• stool
  Bleeding in the lungs: Chest pain, cough, trouble breathing, wheezing, fast heartbeat
• Stomach bleeds: tiredness, vomiting blood, stomach cramps, black or tarry stool, blood in the stool
• Stroke: sudden numbness or weakness in the arm, leg, or face, confusion, trouble seeing, headache, difficulty walking
• Blood clot in the lungs: cough, chest pain, trouble breathing, racing heart
• Blood clot in the heart: chest pain, stomach discomfort, sweating, nausea, dizziness
• Blood clot in the leg: leg cramp, swelling, pain, muscle tightness
• Dangerously high blood pressure: anxiety, blurry vision, confusion, chest pain, nausea, vomiting, headache
  Serious kidney problems: trouble thinking clearly, nausea, vomiting, feeling very tired, urinating less than usual
• Serious infusion reactions: trouble breathing, itching or hives, flushing, swelling, chest pain, fast heartbeat, dizziness, fainting

There are no major drug interactions listed for Mvasi. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Amgen Inc.

Based on findings from animal studies and their mechanism of action, Mvasi may cause fetal harm in pregnant women. Women who can become pregnant should use effective contraception during treatment with Mvasi and for 6 months after the last dose.

• Bevacizumab-AWWB