MidodrinePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  1. Medication
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  2. Midodrine HCl
    Generic for Proamatine
    20 tablets $6.3 USD
    Save $54.10
  3. Midodrine HCl
    Generic for Proamatine
    30 tablets $8.7 USD
    Save $81.90
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Do you need a prescription for midodrine?

Yes, midodrine is only available with a valid physician Rx.

How much is midodrine without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase midodrine, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for midodrine in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a midodrine savings card?

Yes. Save up to 90% on your midodrine with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a midodrine coupon provider in the US?

No. Now Patient does not provide midodrine coupons or FREE midodrine samples.

Do you accept commercial, Medicare or Medicaid coverage for midodrine in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much midodrine?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using midodrine. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much midodrine. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

US brand name of midodrine and manufacturer

Midodrine is FDA-approved and available in the US under the brand names Orvaten and ProAmatine. It is manufactured by Shire US Inc.

UK brand name of midodrine and manufacturer

Midodrine is not currently available in the UK.

Prescription requirement for midodrine

Midodrine is a prescription medication and requires a prescription from a healthcare provider.

Active ingredient of midodrine and mechanism of action

The active ingredient in midodrine is midodrine hydrochloride. It is an alpha-1 adrenergic agonist that works by stimulating the alpha-1 receptors in blood vessels, leading to constriction and increased blood pressure. This helps improve blood flow and treat low blood pressure.

Uses of midodrine

Midodrine is primarily used for the treatment of symptomatic orthostatic hypotension, a condition characterized by a sudden drop in blood pressure upon standing up. It helps increase blood pressure and reduce symptoms such as lightheadedness, dizziness, and fainting.

Dosage forms of midodrine

Midodrine is available in the form of oral tablets for administration.

Dosage of midodrine

Your dose of midodrine will vary depending on the individual patient and the severity of orthostatic hypotension. It is typically started at a low dose and gradually increased under the guidance of a healthcare provider. The medication is usually taken three times daily, with the last dose taken at least 4 hours before bedtime.

Contraindications and warnings for midodrine

  • Midodrine may cause supine hypertension (high blood pressure when lying down). Blood pressure should be carefully monitored during treatment, and dosage adjustments may be necessary
  • It is important to avoid taking midodrine within 4 hours of bedtime to minimize the risk of supine hypertension
  • Midodrine may cause urinary retention in some individuals. Patients with urinary tract problems or a history of urination impairment should use midodrine with caution
  • Certain medical conditions, such as heart disease, pheochromocytoma, overactive thyroid, kidney disease, or liver disease, may require additional monitoring or dosage adjustments when taking midodrine
  • Midodrine should be used with caution in patients with certain eye conditions, such as glaucoma
  • It is not known if midodrine passes into breast milk. Speak to your doctor before breast-feeding

Side effects of midodrine

In clinical trials common side effects of midodrine may include:

  • Supine hypertension
  • Headache
  • Shivering or goosebumps
  • Urinary urgency
  • Itching or tingling sensation on the scalp

Contact a healthcare professional for medical advice if you experience any severe or persistent side effects.

Interactions with other drugs

Midodrine may interact with medications that affect blood pressure or heart rate such as doxazosin, prazosin, and terazosin, beta blockers such as timolol, digoxin, and fludrocortisone.. It is important to inform your healthcare provider about all the medications you are taking, including prescription drugs, nonprescription medications, supplements, and herbal products to prevent drug interactions.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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