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Metronidazole is available as a 375 mg oral capsule and a 250 mg and 500 mg oral tablet.

Metronidazole is a nitroimidazole antibiotic that is used to treat many different infections caused by certain bacteria and parasites, including sexually transmitted diseases (STDs) (such as trichomoniasis), infections caused by parasites of the intestines (amebiasis), skin infections, heart infections, and brain infections.

Metronidazole is a nitroimidazole antibiotic that affects the DNA of bacteria or parasites causing the infection. This leads to death of the bacteria, which stops their growth.

Metronidazole will be dosed depending on the type of infection you have. The most important thing is that you take it exactly as prescribed and finish the full course of antibiotics even if you’re feeling better.

Metronidazole is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a prior history of hypersensitivity to Metronidazole or other nitroimidazole derivatives and in patients with trichomoniasis, Metronidazole Tablets is contraindicated during the first trimester of pregnancy.

Common side effects of Metronidazole include:

• Low appetite
• Headache
• Nausea
• Metallic taste
• Diarrhea
• Stomach pain
• Stomach cramps

Serious side effects are rare with Metronidazole: Contact your healthcare provider immediately if you experience any of the following.

• Severe skin reaction: rash, blistering or peeling of skin, hives, fever, painful sores in your mouth or around your eyes
• Liver damage in people with Cockayne syndrome: stomach pain, nausea, change in stool color, yellowing of skin or whites of your eyes

The following medications may interact with Metronidazole:

• Disulfiram- – Psychotic reactions have been reported in alcoholic patients who are using Metronidazole and disulfiram concurrently. Metronidazole should not be given to patients who have taken disulfiram within the last two weeks
• Alcoholic Beverages – Abdominal cramps, nausea, vomiting, headaches, and flushing may occur if alcoholic beverages or products containing propylene glycol are consumed during or following Metronidazole
• Warfarin and other Oral Anticoagulants – Metronidazole has been reported to potentiate the anticoagulant effect of warfarin and other oral coumarin anticoagulants, resulting in a prolongation of prothrombin time. When Metronidazole is prescribed for patients on this type of anticoagulant therapy, prothrombin time and INR should be carefully monitored
• Lithium – In patients stabilized on relatively high doses of lithium, short-term Metronidazole therapy has been associated with elevation of serum lithium and, in a few cases, signs of lithium toxicity. Serum lithium and serum creatinine levels should be obtained several days after beginning Metronidazole to detect any increase that may precede clinical symptoms of lithium intoxication
• Busulfan – Metronidazole has been reported to increase plasma concentrations of busulfan, which can result in an increased risk for serious busulfan toxicity. Metronidazole should not be administered concomitantly with busulfan unless the benefit outweighs the risk.
• Drugs that Inhibit CYP450 Enzymes – The simultaneous administration of drugs that decrease microsomal liver enzyme activity, such as cimetidine, may prolong the half-life and decrease plasma clearance of Metronidazole
• Drugs that Induce CYP450 Enzymes – The simultaneous administration of drugs that induce microsomal liver enzymes, such as phenytoin or phenobarbital, may accelerate the elimination of Metronidazole, resulting in reduced plasma levels; impaired clearance of phenytoin has also been reported
• Drugs that Prolong the QT interval – QT prolongation has been reported, particularly when Metronidazole was administered with drugs with the potential for prolonging the QT interval

Various FDA-approved generic manufacturers

It is not known if Metronidazole will harm your unborn baby. You should talk to your healthcare provider before taking this medication if you are pregnant.

• Flagyl
• Metrocream
• Metrogel-Vaginal
• Rosadan