Save up to 90% on Metoclopramide with Coupons, Discount Cards & Patient Assistance Programs

Metoclopramide is available as a 5 mg and 10 mg oral tablet/orally disintegrating tablet and a 5 mg/5 ml oral solution.

Metoclopramide is a dopamine agonist that is used to treat:
Delayed stomach-emptying caused by diabetes (diabetic gastroparesis) Severe acid reflux (gastroesophageal reflux disease or GERD) when other medications haven’t worked

Metoclopramide mainly works as a dopamine antagonist (blocks dopamine). Dopamine is a chemical made by your brain that affects many parts of your body, including the digestive tract.
Dopamine normally slows down muscle movements in your gut, causing food to stay in your stomach longer. This can lead to nausea, vomiting, and heartburn. By blocking dopamine, Metoclopramide helps speed up muscle movements in your gut and relieve these stomach-related symptoms. Metoclopramide also tightens a muscle in your gut to stop the backflow of stomach acid into your throat. This helps prevent heartburn.

Metoclopramide is typically dosed at 10 mg to 15 mg by mouth 4 times daily. It should be taken 30 minutes before meals and at bedtime. Your dose might be lower if you are older than 65 years old, have liver or kidney conditions, or are taking medications that interact with Metoclopramide.

Metoclopramide is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following:

• History of TD or dystonic reaction to Metoclopramide
  When stimulation of gastrointestinal motility might be dangerous
• Pheochromocytoma, catecholamine-releasing paragangliomas
• Epilepsy
• Hypersensitivity to Metoclopramide

Common side effects of Metoclopramide:

• Restlessness
• Drowsiness
• Lack of energy
• Tiredness

Serious side effects are rare with Metoclopramide. Contact your healthcare provider immediately if you experience any of the following.

• Uncontrolled muscle movements (tardive dyskinesia): sticking out your tongue, puffing out your cheeks, puckering your mouth, lip smacking, chewing, and shaking in your arms and legs
• Neuroleptic malignant syndrome (NMS): very high fever, stiff muscles, problem thinking clearly, very fast or uneven heartbeat, and sweating
• Suicidal thoughts and behavior
• Seizures

The following medications may interact with Metoclopramide:

• Antipsychotics: Potential for additive effects, including TD, EPS, and NMS; avoid concomitant use.
• CNS depressants: Increased risk of CNS depression. Avoid concomitant use and monitor for adverse reactions
• Strong CYP2D6 inhibitors (e.g., quinidine, bupropion, fluoxetine, and paroxetine): See Full Prescribing Information for recommended dosage reductions.
• MAO inhibitors: Increased risk of hypertension; avoid concomitant use
• Additional drug interactions: See Full Prescribing Information

Various FDA-approved generic manufacturers

It is not known if Metoclopramide will harm your unborn baby. You should talk to your healthcare provider before taking this medication if you are pregnant.

• Reglan