metoclopramide
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Manufactured by various FDA-approved generic manufacturers.
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Useful information about metoclopramide
What dosages is metoclopramide available in?
metoclopramide is available as a 5 mg and 10 mg oral tablet/orally disintegrating tablet and a 5 mg/5 ml oral solution.
What is metoclopramide used for?
metoclopramide is a dopamine agonist that is used to treat:
Delayed stomach-emptying caused by diabetes (diabetic gastroparesis) Severe acid reflux (gastroesophageal reflux disease or GERD) when other medications haven’t worked
How does metoclopramide work?
metoclopramide mainly works as a dopamine antagonist (blocks dopamine). Dopamine is a chemical made by your brain that affects many parts of your body, including the digestive tract.
Dopamine normally slows down muscle movements in your gut, causing food to stay in your stomach longer. This can lead to nausea, vomiting, and heartburn. By blocking dopamine, metoclopramide helps speed up muscle movements in your gut and relieve these stomach-related symptoms. metoclopramide also tightens a muscle in your gut to stop the backflow of stomach acid into your throat. This helps prevent heartburn.
How do I take metoclopramide?
metoclopramide is typically dosed at 10 mg to 15 mg by mouth 4 times daily. It should be taken 30 minutes before meals and at bedtime. Your dose might be lower if you are older than 65 years old, have liver or kidney conditions, or are taking medications that interact with metoclopramide.
Is it safe for me to take metoclopramide?
metoclopramide is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following:
- History of TD or dystonic reaction to metoclopramide
When stimulation of gastrointestinal motility might be dangerous - Pheochromocytoma, catecholamine-releasing paragangliomas
- Epilepsy
- Hypersensitivity to metoclopramide
metoclopramide Common Side Effects
Common side effects of metoclopramide:
- Restlessness
- Drowsiness
- Lack of energy
- Tiredness
metoclopramide Serious Side Effects
Serious side effects are rare with metoclopramide. Contact your healthcare provider immediately if you experience any of the following.
- Uncontrolled muscle movements (tardive dyskinesia): sticking out your tongue, puffing out your cheeks, puckering your mouth, lip smacking, chewing, and shaking in your arms and legs
- Neuroleptic malignant syndrome (NMS): very high fever, stiff muscles, problem thinking clearly, very fast or uneven heartbeat, and sweating
- Suicidal thoughts and behavior
- Seizures
Effects of other drugs, drug classes and over-the-counter products on metoclopramide
The following medications may interact with metoclopramide:
- Antipsychotics: Potential for additive effects, including TD, EPS, and NMS; avoid concomitant use.
- CNS depressants: Increased risk of CNS depression. Avoid concomitant use and monitor for adverse reactions
- Strong CYP2D6 inhibitors (e.g., quinidine, bupropion, fluoxetine, and paroxetine): See Full Prescribing Information for recommended dosage reductions.
- MAO inhibitors: Increased risk of hypertension; avoid concomitant use
- Additional drug interactions: See Full Prescribing Information
Who makes metoclopramide?
Various FDA-approved generic manufacturers
Is metoclopramide safe in pregnancy?
It is not known if metoclopramide will harm your unborn baby. You should talk to your healthcare provider before taking this medication if you are pregnant.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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