LOTREL

Experience swelling in your hands or feet, rapid weight gain, new or worsened chest pain, fever, chills, sore throat, body aches, flu symptoms, high potassium levels (resulting in nausea, weakness, tingling sensations, chest pain, irregular heartbeats, or loss of movement).

Wondering which blood pressure medications to avoid? Alpha-blockers and alpha-2 agonists are typically not recommended as first-line treatments due to their potential to cause blood pressure fluctuations.

Concerned about amlodipine causing weight gain? It’s unlikely, as controlled clinical trials showed that less than 1% of participants reported weight gain.

Lotrel (amlodipine / benazepril) combines two top-choice medications to lower blood pressure and reduce the risk of heart attack, stroke, and heart failure. To maximize its benefits, it’s advisable to maintain a healthy diet and regular exercise routine.

Consuming significant amounts of grapefruit or grapefruit juice can increase amlodipine concentration in your body and worsen side effects. You may need to refrain from grapefruit consumption while on amlodipine.

Common side effects of amlodipine include swelling, fatigue, palpitations, and flushing. Some side effects may become more pronounced with higher doses.

Looking to prevent weight gain while on Amlodipine? You can manage your weight by adopting a healthy diet and exercise regimen. If weight gain becomes problematic, consult your doctor about alternative medications.

Diuretics used to manage high blood pressure, such as hydrochlorothiazide, Dyazide, or Maxzide, can lead to temporary weight reduction due to fluid loss.

Studies suggest that taking your blood pressure medication at night rather than in the morning can improve nighttime blood pressure control without compromising daytime blood pressure and reduce your overall risk of cardiovascular disease by 45%.

Keep in mind that amlodipine can induce ankle or leg swelling, a common side effect that may contribute to weight gain.

A single dose of benazepril/amlodipine has a lasting antihypertensive effect for 24 hours. Daily doses of benazepril (10-20 mg) and amlodipine (2.5-10 mg) reduce seated blood pressure by approximately 10-25/6-13 mmHg 24 hours after administration.

Common side effects of this medication include insomnia, nervousness, anxiety, tremors, decreased libido, flushing, hot flashes, rash, skin nodules, dermatitis, dry mouth, nausea, abdominal pain, dyspepsia, and esophagitis.

While benazepril may be used to prevent or treat kidney problems, it can rarely cause or exacerbate serious kidney issues.

Be cautious of potential dehydration while taking Lotrel, which can lead to low blood pressure, electrolyte imbalances, or kidney problems. Continue using Lotrel as prescribed, even if you feel well, as high blood pressure often presents no symptoms.

Diuretics, also known as water pills, are used to treat high blood pressure and swelling but can sometimes lead to dehydration, which may adversely affect your kidneys.

For individuals with asthma or a history of severe swelling (angioedema), lisinopril may not be the best choice due to the risk of adverse reactions. Amlodipine may be a preferable alternative in such cases.

Once-daily administration of losartan 50 mg, either alone or in combination with HCTZ 12.5 mg, proves more effective than amlodipine 5/10 mg in lowering blood pressure and albuminuria in patients with essential hypertension complicated by impaired renal function.

Amlodipine (Norvasc) is prescribed for high blood pressure and coronary artery disease. Common side effects include swelling, fatigue, palpitations, and flushing. Some side effects are more frequent with higher doses and are reported more frequently in women than men.

Recent research indicates that amlodipine may increase levels of the enzymes AST and ALT in the bloodstream, suggesting a potential risk of drug-induced liver injury.

Avoid consuming excessive amounts of potassium-rich foods while taking benazepril, as it may lead to hyperkalemia in some patients using ACE inhibitors, possibly due to potassium-rich salt substitutes.

This product may rarely lead to severe liver disease. Seek immediate medical attention if you experience symptoms such as persistent nausea/vomiting, loss of appetite, abdominal pain, yellowing of eyes/skin, or dark urine.

Antibiotics like clarithromycin, erythromycin, or rifampicin, calcium channel blockers such as diltiazem or verapamil, itraconazole or ketoconazole (antifungal medicines), and medications for HIV or HCV (hepatitis C virus).

Amlodipine, one of the most commonly prescribed calcium channel blocker drugs for hypertension, has been shown to help maintain renal function in patients with hypertension.

There is substantial evidence of fetal risk during human pregnancy. Amlodipine/benazepril 5 mg / 20 mg is not classified as a controlled substance under the Controlled Substances Act (CSA).

Lotrel (amlodipine / benazepril) combines two primary medications to reduce blood pressure and also lowers the risk of heart attack, stroke, and heart failure. However, to maximize the benefits of this medication, it is recommended to maintain a healthy diet and regular exercise routine.

Teva Pharmaceuticals has initiated a voluntary recall in the United States at the patient level for all batches of Amlodipine / Valsartan combination tablets and Amlodipine / Valsartan / Hydrochlorothiazide combination tablets (see table below) due to the detection of an impurity exceeding specification limits in an active ingredient.

The high-dose combination of amlodipine/benazepril at 10/40 mg/day resulted in significant reductions from baseline in mean seated systolic blood pressure (MSSBP) by 14.33 mmHg and mean seated diastolic blood pressure (MSDBP) by 13.60 mmHg in White patients (p < 0.0001) and by 14.89 mmHg and 12.79 mmHg, respectively, in Black patients (p < 0.0001).

Morning administration is preferred as it provides more effective 24-hour blood pressure coverage compared to evening dosing.

Amlodipine has an elimination half-life of 30 to 50 hours, which is the time it takes for your body to reduce plasma levels by half. It typically takes approximately 11.5 days (5.5 x 50 hours = 275 hours) for the medication to be completely eliminated from your system.

Amlodipine relaxes blood vessels, leading to a reduction in blood pressure, while lisinopril inhibits the production of angiotensin II, resulting in decreased blood pressure.

The combination of amlodipine and valsartan is used when a single medication is insufficient to lower blood pressure effectively.

Lotrel (amlodipine / benazepril) is also known by other brand names, including Amlobenz, Prinivil, Qbrelis, Zestril, Katerzia, Norliqva, and Norvasc.

Several other calcium channel blockers, such as felodipine and nifedipine, work similarly to amlodipine in preventing angina. However, diltiazem and verapamil are calcium channel blockers used for angina that function differently.

While taking these medications, you may experience flushing, headaches, or swelling. Felodipine and Lercanidipine are generally considered safer than Amlodipine but may be slightly less effective. If you are dissatisfied with your body’s response to Amlodipine, consult your doctor about switching to an alternative medication.

The generic name for LOTRIL is Amlodipine/Benazepril.

Other brand names include Lotensin HCT, Prinivil, Qbrelis, Zestril, Katerzia, Norliqva, and Norvasc for the combination of benazepril, hydrochlorothiazide, lisinopril, and amlodipine.

Lotrel (amlodipine / benazepril) is a combination medication that includes two active ingredients working together to lower blood pressure. Amlodipine is a calcium channel blocker (CCB) that relaxes blood vessels, while benazepril is an angiotensin-converting enzyme (ACE) inhibitor.

Lotrel is available in capsule form with amlodipine besylate doses of 2.5 mg, 5 mg, or 10 mg, along with benazepril hydrochloride doses of 10 mg, 20 mg, or 40 mg, offering various combinations: 2.5/10 mg, 5/10 mg, 5/20 mg, 5/40 mg, 10/20 mg, and 10/40 mg.

The price for Lotrel oral capsules (5 mg-10 mg) varies, with an average cost of around $1,163 for a supply of 100 capsules, depending on the pharmacy. Please note that quoted prices are for cash-paying customers and may not apply to insurance plans.

Amlodipine may also be marketed under different names such as amlodipine besylate, amlodipine maleate, or amlodipine mesilate, all of which have the same effectiveness.

Carvedilol is more effective at lowering blood pressure than metoprolol, and metoprolol may raise triglyceride levels, whereas carvedilol typically does not have this effect. Additionally, metoprolol may increase blood sugar levels in individuals with diabetes.

For heart failure, three beta blockers are considered first-choice options: carvedilol, metoprolol succinate (the extended-release form of metoprolol), and bisoprolol. These selective beta blockers are often associated with fewer side effects for some individuals.