KYPROLIS
Used for Cancer
Are you tired of high medication costs? Our service offers unbeatable savings on your KYPROLIS prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.
Manufactured by Amgen Inc.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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KYPROLIS key facts
What is KYPROLIS?
KYPROLIS is the brand name for carfilzomib IV infusion.
What dosages is KYPROLIS available in?
KYPROLIS is available as
What is KYPROLIS used for?
KYPROLIS is a proteasome inhibitor and is used for the following:
- Multiple myeloma that’s been previously treated with at least one therapy
- Given by itself; or
- Given with other medications such as lenalidomide (Revlimid), Darzalex (daratumumab), and dexamethasone
How does KYPROLIS work?
KYPROLIS is a proteasome inhibitor. It works by attaching to proteins called proteasomes in multiple myeloma cancer cells. This blocks the proteasomes from properly breaking down other proteins that the cell no longer needs to keep the cell alive. Multiple myeloma cancer cells make more proteins than normal cells. So when KYPROLIS blocks how proteasomes work, the cancer cells can’t function correctly and usually die. As a result, the myeloma cells can’t grow and spread as well.
How do I take KYPROLIS?
KYPROLIS is dosed as follows:
- The dose is based on your body surface area (BSA, m2 units), which is calculated using your height and weight measurements. If your BSA is above 2.2 m2, your dose will be calculated using a BSA of 2.2 m2
- KYPROLIS is given as an infusion through the veins (IV), usually once or twice a week. In general, the medication is given between weeks 1 and 3 in every 4-week treatment cycle
- For once-weekly dosing: The usual starting dose is 20 mg/m2 given IV once a week. After the first week, your provider might raise your dose to 70 mg/m2 once a week
- For twice-weekly dosing: The usual starting dose is 20 mg/m2 given IV twice a week. After the first week, your provider might raise your dose to either 27 mg/m2 or 56 mg/m2 twice a week
- Your dose and your treatment schedule will vary depending on whether you’re taking KYPROLIS by itself or together with other medications for your cancer. Your dose might also differ if you have liver problems or have serious side effects from KYPROLIS
Is it safe for me to take KYPROLIS?
KYPROLIS is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
KYPROLIS Common Side Effects
Common side effects of KYPROLIS:
- Anemia
- Tiredness
- Low platelet counts
- Nausea
- Trouble breathing
- Fever
- Diarrhea
- Low white blood cell counts
- Headache
- Cough
- Swelling in legs
KYPROLIS Serious Side Effects
Serious side effects are rare with KYPROLIS. Contact your healthcare provider immediately if you experience any of the following.
- Serious heart problems: trouble breathing, chest pain, swelling in legs, feeling lightheaded, abnormal heartbeat
- Serious kidney problems: high creatinine levels on blood tests, urinating less often, having less urine, weakness, confusion, nausea
- Tumor lysis syndrome: abnormal heartbeat, muscle cramps, muscle weakness, abnormal electrolyte levels (high potassium, high uric acid, high creatinine, low calcium)
- Serious lung problems: sudden cough, trouble breathing, very quick breathing, clicking or rattling sound when breathing, pain when breathing
- Severely high blood pressure: sudden headache, confusion, chest pain, trouble breathing, blood pressure reading higher than 180/120
- Blood clots: swelling or red and warm skin in one arm or one leg, sudden trouble breathing, sudden chest pain
- Bleeding: nosebleeds, blood in stool or urine, coughing up blood, sudden headache, severe tiredness
- Serious brain and nerve problems: seizures, confusion, vision or speech changes
Effects of other drugs, drug classes and over-the-counter products on KYPROLIS
There are no major drug interactions listed for KYPROLIS. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.
Who makes KYPROLIS?
Amgen Inc.
Is KYPROLIS safe in pregnancy?
Based on its mechanism of action and findings in animals, KYPROLIS can cause fetal harm when administered to a pregnant woman. Pregnancy testing on females of reproductive potential should be done prior to initiating KYPROLIS treatment.
- Females who can become pregnant should use effective contraception during treatment with KYPROLIS and for 6 months following the last dose
- Males with female sexual partners who can become pregnant should use effective contraception during treatment with KYPROLIS and for 3 months following the last dose
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my KYPROLIS prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your KYPROLIS prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient KYPROLIS savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient KYPROLIS savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for KYPROLIS | Canadian Prescription Savings* for KYPROLIS | KYPROLIS Drug Coupon* | KYPROLIS Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of KYPROLIS?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for KYPROLIS | Canadian Prescription Savings* for KYPROLIS | KYPROLIS Drug Coupon* | KYPROLIS Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the KYPROLIS savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the KYPROLIS drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for KYPROLIS, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the KYPROLIS prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, KYPROLIS is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed KYPROLIS for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the KYPROLIS prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the KYPROLIS prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for KYPROLIS
If you are having trouble paying for your KYPROLIS medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for KYPROLIS you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- KYPROLIS is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers KYPROLIS
- If KYPROLIS is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for KYPROLIS
If you are having trouble paying for your KYPROLIS medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for KYPROLIS you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers KYPROLIS
- If KYPROLIS is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for KYPROLIS
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your KYPROLIS treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for KYPROLIS you will need to meet the following criteria:
- You must be currently insured and have coverage for KYPROLIS
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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