KOMBIGLYZE XR
Used for Type 2 Diabetes
Are you tired of high medication costs? Our service offers unbeatable savings on your KOMBIGLYZE XR prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.
Manufactured by Bristol-Myers Squibb
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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KOMBIGLYZE XR key facts
What is KOMBIGLYZE XR?
KOMBIGLYZE XR is the brand name for saxagliptin and metformin HCl and is available as an extended-release tablet.
What dosages is KOMBIGLYZE XR available in?
KOMBIGLYZE XR is available as an extended-release tablet that contains one of the following combinations:
- 5 mg saxagliptin/500 mg metformin HCl
- 5 mg saxagliptin/1000 mg metformin HCl
- 2.5 mg saxagliptin/1000 mg metformin HCl
What is KOMBIGLYZE XR used for?
KOMBIGLYZE XR is a DPP4 inhibitor / Biguanide combination used to treat type 2 diabetes.
How does KOMBIGLYZE XR work?
KOMBIGLYZE XR is a combination of metformin (a biguanide) and saxagliptin (a DPP4 inhibitor). KOMBIGLYZE XR works by lowering the amount of sugar made by your liver, decreasing the amount of sugar absorbed by your intestine, increasing the amount of insulin your body makes, and helps your body respond better to insulin.
How do I take KOMBIGLYZE XR?
The starting dose of KOMBIGLYZE XR depends on what medications you are currently taking for diabetes. Depending on how you respond, your healthcare provider will adjust your dose. The maximum dose for KOMBIGLYZE XR is 5 mg/2000 mg (saxagliptin/metformin) by mouth once daily with dinner.
Is it safe for me to take KOMBIGLYZE XR?
KOMBIGLYZE XR is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:
- Renal impairment
- Hypersensitivity to metformin hydrochloride
Metabolic acidosis, including diabetic ketoacidosis - History of a serious hypersensitivity reaction (e.g., anaphylaxis, angioedema, exfoliative skin conditions) to KOMBIGLYZE XR or saxagliptin
KOMBIGLYZE XR Common Side Effects
Common side effects of KOMBIGLYZE XR:
- Diarrhea
- Nausea and vomiting
- Headache
- Upper respiratory tract infection (a viral infection that affects the nose, throat, and airways)
- Bladder infection
- Runny or stuffy nose and sore throat
KOMBIGLYZE XR Serious Side Effects
Serious side effects are rare with KOMBIGLYZE XR. Contact your healthcare provider immediately if you experience any of the following.
- Build up of lactic acid in the blood (feeling of increased tiredness and weakness, stomach pain, muscle pain, increased sleepiness, breathing problems)
- Signs of an allergic reaction like trouble breathing or swallowing, swelling (of your face, lips, tongue, or throat), peeling skin, rash, or hives
- Inflammation of the pancreas (severe and persistent stomach pain, back pain, vomiting)
- Heart failure (feeling out of breath, swelling of your feet, ankles or legs, fast increase in weight)
- Large fluid-filled blisters on the skin
Effects of other drugs, drug classes and over-the-counter products on KOMBIGLYZE XR
The following medications may interact with KOMBIGLYZE XR:
- Coadministration with strong CYP3A4/5 inhibitors (e.g., ketoconazole) significantly increases saxagliptin concentrations. Limit
- KOMBIGLYZE XR dose to 2.5 mg/1000 mg once daily
- Cationic drugs eliminated by renal tubular secretion may reduce metformin elimination: use with caution
Who makes KOMBIGLYZE XR?
Bristol-Myers Squibb
Is KOMBIGLYZE XR safe in pregnancy?
There are no adequate and well-controlled studies in pregnant women with KOMBIGLYZE XR or its individual components. Because animal reproduction studies are not always predictive of
human response, KOMBIGLYZE XR, like other antidiabetic medications, should be used during pregnancy only if clearly needed
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my KOMBIGLYZE XR prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your KOMBIGLYZE XR prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient KOMBIGLYZE XR savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient KOMBIGLYZE XR savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for KOMBIGLYZE XR | Canadian Prescription Savings* for KOMBIGLYZE XR | KOMBIGLYZE XR Drug Coupon* | KOMBIGLYZE XR Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of KOMBIGLYZE XR?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for KOMBIGLYZE XR | Canadian Prescription Savings* for KOMBIGLYZE XR | KOMBIGLYZE XR Drug Coupon* | KOMBIGLYZE XR Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the KOMBIGLYZE XR savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the KOMBIGLYZE XR drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for KOMBIGLYZE XR, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the KOMBIGLYZE XR prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, KOMBIGLYZE XR is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed KOMBIGLYZE XR for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the KOMBIGLYZE XR prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the KOMBIGLYZE XR prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for KOMBIGLYZE XR
If you are having trouble paying for your KOMBIGLYZE XR medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for KOMBIGLYZE XR you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- KOMBIGLYZE XR is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers KOMBIGLYZE XR
- If KOMBIGLYZE XR is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for KOMBIGLYZE XR
If you are having trouble paying for your KOMBIGLYZE XR medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for KOMBIGLYZE XR you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers KOMBIGLYZE XR
- If KOMBIGLYZE XR is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for KOMBIGLYZE XR
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your KOMBIGLYZE XR treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for KOMBIGLYZE XR you will need to meet the following criteria:
- You must be currently insured and have coverage for KOMBIGLYZE XR
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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In the UK, we are located at:
NowPatient
28 Chipstead Valley Road
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Surrey
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NowPatient
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Suite 4200 #1263
78759
Austin, TX
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Who owns NowPatient?
NowPatient is owned and operated by Infohealth Ltd, a licensed online pharmacy with services spanning the UK, US and Rest of the World. Infohealth Ltd is registered in England and Wales under company number 04004930 and our registered office is at Lynwood House, 373 – 375 Station Road, Harrow, England, HA1 2AW.
Our website is www.nowpatient.com. Our App is called “NowPatient” and can be downloaded from the App Store (for Apple devices) or Google Play (for Android devices).
Can you tell me more about your NHS online pharmacy?
NowPatient’s Pharmaceutical services in the UK are provided by Infohealth Limited trading as ‘Infohealth Pharmacy’.
Our dispensing pharmacy is regulated and authorized for internet sales by the General Pharmaceutical Council (GPhC), registration number 1036487. You can view our license credentials on the General Pharmaceutical Council website. Our superintendent pharmacist who is responsible for the safe and effective oversight of medicines supplies is Mr Amish Patel (Registration Number 2042705).
Medicines are not ordinary items of commerce. All medicines or healthcare product sales are made under the supervision of a registered pharmacist who is licensed by the GPhC. At all times, we endeavour to provide a professional and transparent service whose primary goal is to ensure that the best interests of the patient are served.
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Can you tell me more about NowPatient’s US services?
Our head of US services is Dr. Jamie Winn.
You can lower the cost of your prescription medications using our various savings programs which include drug coupons, savings card and manufacturer-sponsored patient assistance programs.
We do not provide any prescribing services or dispensing services in the United States.
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