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Ketoconazole is available as a 200 mg oral tablet.

Ketoconazole is an antifungal that is used to treat certain fungal infections that has spread throughout the body.

Ketoconazole is an azole antifungal medication that works by stopping the fungus from being able to make a protective covering. This causes the fungus to not grow or survive.

Ketoconazole is typically started at 200 mg by mouth once daily. If needed, your provider might raise the dose to 400 mg once daily. Your child’s provider will calculate the dose based on your child’s body weight.

Ketoconazole is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are taking certain CYP3A4 substrates or have acute or chronic liver disease.

Common side effects of Ketoconazole:

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Stomach pain
• Passing gas
• Dry mouth
• Tongue discoloration

Serious side effects are rare with Ketoconazole. Contact your healthcare provider immediately if you experience any of the following.

• Liver damage: nausea, vomiting, feeling tired, stomach pain, yellowing of your skin or whites of your eye (jaundice), dark-colored urine, pale-colored stool
• Abnormal heart rhythm (QT prolongation): chest pounding, short of breath, chest pain, feeling faint or lightheaded
• Extremely low cortisol levels (adrenal insufficiency): feeling very weak or tired, dizziness, weight loss, no appetite
• Serious allergic reaction: hives, rash, blisters, skin reddening, swelling of the lips or tongue, difficulty breathing

The following medications may interact with Ketoconazole:

• Ketoconazole is a substrate and potent inhibitor of CYP3A4. Therefore, the following drug interactions may occur when Ketoconazole is co-administered with other drugs that interact with CYP3A4. Some examples include alprazolam, midazolam, triazolam, HMG-CoA reductase inhibitors (lovastatin, simvastatin), cisapride, nisoldipine, dofetilide, pimozide, alfentanil, fentanyl, sulfentanil Indinavir, saquinavir, amlodipine, felodipine, nicardipine, nifedipine, rifabutin, sildenafil, sirolimus (co-administration not recommended), and carbamazepine. See package insert for a full list of drug interactions

Various FDA-approved generic manufacturers

Ketoconazole hasn’t been well-studied in pregnant females. But animal studies suggest and reports show that it can cause harm to unborn babies. Speak with your healthcare provider right away if you find out you’re pregnant or you’re thinking of becoming pregnant while taking Ketoconazole.

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