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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

JANUMET XR Uses, Side Effects, Interactions, Warnings & Dosing



JANUMET XR is the brand name for sitagliptin and metformin and is available as an extended-release oral tablet.

What dosages is JANUMET XR available in?

What dosages is JANUMET XR available in?

JANUMET XR is available as an extended-release oral tablet that contains one of following:

  • sitagliptin 100 mg and metformin HCl 1000 mg
  • sitagliptin 50 mg and metformin HCl 500 mg
  • sitagliptin 50 mg and metformin HCl 1000 mg
What is JANUMET XR used for?

What is JANUMET XR used for?

JANUMET XR is a DPP-4 inhibitor / Biguanide and is used to treat type 2 diabetes.

How does JANUMET XR work?

How does JANUMET XR work?

JANUMET XR is a combination of two different diabetes medications. Metformin is a biguanide. It works by lowering the amount of sugar your liver releases into your blood and lowering the amount of sugar that gets absorbed into the body through your gut. It also helps your body respond better to insulin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It blocks the action of DPP-4, a protein that normally breaks down insulin in the body. By blocking DPP-4, the medication allows insulin to stick around in your body longer to help control your blood sugar levels.

How do I take JANUMET XR?

How do I take JANUMET XR?

JANUMET XR is dosed as follows:

  • Janumet (immediate-release tablets): The typical starting dose is 50 mg/500 mg (sitagliptin/metformin) by mouth twice daily with meals
  • JANUMET XR (extended-release tablets): The typical starting dose is 100 mg/1,000 mg (sitagliptin/metformin) by mouth once daily with a meal

Your dose might differ if you were taking metformin by itself before you started JANUMET XR.

Is it safe for me to take JANUMET XR?

Is it safe for me to take JANUMET XR?

JANUMET XR is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following:
Severe renal impairment: eGFR below 30 mL/min/1.73 m2.
Metabolic acidosis, including diabetic ketoacidosis.
History of a serious hypersensitivity reaction (e.g., anaphylaxis or angioedema) to JANUMET XR, sitagliptin, or metformin.

JANUMET XR Common Side Effects

JANUMET XR Common Side Effects

Common side effects of JANUMET XR:

  • Diarrhea
  • Upper respiratory tract infection
  • Headache
JANUMET XR Serious Side Effects

JANUMET XR Serious Side Effects

Serious side effects are rare with JANUMET XR. Contact your healthcare provider immediately if you experience any of the following.

  • Inflammation of the pancreas: upper belly pain, nausea, vomiting
  • Buildup of lactic acid in the body: sudden drop in blood pressure, low body temperature, slow heart rhythm, feeling weak, stomach pain, nausea
  • Kidney problems: urinating less, itching, swelling of the ankles or feet
  • Heart failure: shortness of breath, unusually fast weight gain, swelling of the legs or feet
  • Severe allergic reaction: hives, blisters, trouble breathing, swelling of the face or throat
Effects of other drugs, drug classes and over-the-counter products on JANUMET XR

Effects of other drugs, drug classes and over-the-counter products on JANUMET XR

The following medications may interact with JANUMET XR:

  • Carbonic anhydrase inhibitors may increase risk of lactic acidosis
  • Consider more frequent monitoring
  • Drugs that reduce metformin clearance (such as ranolazine vandetanib, dolutegravir, and cimetidine) may increase the accumulation of metformin. Consider the benefits and risks of concomitant use.
  • Alcohol can potentiate the effect of metformin on lactate metabolism
  • Warn patients against excessive alcohol intake
Who makes JANUMET XR?

Who makes JANUMET XR?

Merck & Co., Inc.

Is JANUMET XR safe in pregnancy?

Is JANUMET XR safe in pregnancy?

It is not known if JANUMET XR can harm your unborn baby. JANUMET XR should only be used during pregnancy if the benefit to you is worth the possible risk to your baby.


What to do if you missed your JANUMET XR dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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