Used for Cancer

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Manufactured by various FDA-approved generic manufacturers.

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Updated on 24 Apr 2024

ixazomib Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is ixazomib available in?

What dosages is ixazomib available in?

ixazomib is available as a 2.3 mg, 3 mg, and 4 mg oral capsule.

What is ixazomib used for?

What is ixazomib used for?

ixazomib is an anticancer agent and is used to treat multiple myeloma in people whose cancer came back after receiving anticancer treatments.

How does ixazomib work?

How does ixazomib work?

ixazomib is a type of targeted therapy known as a proteasome inhibitor. It works by blocking a group of proteins, called proteasomes, inside cancer cells. Typically, proteasomes help cells break down proteins that they no longer need. When ixazomib blocks proteasomes from working, cell waste builds up, which causes cancer cells to die.

How do I take ixazomib?

How do I take ixazomib?

ixazomib is typically taken along with lenalidomide (Revlimid) and dexamethasone. The typical starting dose is to take 4 mg of ixazomib by mouth once a week during the first 3 weeks (on days 1, 8, and 15) of a 4-week treatment cycle. Your dose of ixazomib might be different if you’re taking other medications that might interact with ixazomib, or have liver or kidney problems.

Is it safe for me to take ixazomib?

Is it safe for me to take ixazomib?

ixazomib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

ixazomib Common Side Effects

ixazomib Common Side Effects

Common side effects of ixazomib:

  • Low platelet count
  • Low white blood cell count
  • Diarrhea
  • Constipation
  • Nausea
  • Nerve pain (peripheral neuropathy)
  • Back pain
  • Sore throat, runny nose, and other symptoms of sinus or throat infections
  • Rash
  • Swelling of arms and legs
  • Vomiting
ixazomib Serious Side Effects

ixazomib Serious Side Effects

Serious side effects are rare with ixazomib. Contact your healthcare provider immediately if you experience any of the following.

  • Severe loss of fluids and electrolytes: dizziness, confusion, fainting, feeling tired, feeling thirsty, dry skin, vomiting or diarrhea that’s difficult to stop, not making much urine
  • Serious blood clots in small arteries: tiredness, nausea, vomiting, bruising, rash-like patches on the skin, nosebleeds, blood in the urine, pale skin
  • Serious liver problems: tiredness, loss of appetite, nausea or vomiting, dark urine, stomach pain, yellowing of the eyes or skin
  • Serious skin reactions: new or worsening rash, severe blistering or peeling of your skin, mouth sores
Effects of other drugs, drug classes and over-the-counter products on ixazomib

Effects of other drugs, drug classes and over-the-counter products on ixazomib

The following medications may interact with ixazomib:

  • Strong CYP3A inducers: Avoid concomitant use with ixazomib
Who makes ixazomib?

Who makes ixazomib?

Various FDA-approved generic manufacturers

Is ixazomib safe in pregnancy?

Is ixazomib safe in pregnancy?

ixazomib can harm your unborn baby. For females, avoid becoming pregnant during treatment with ixazomib. Your healthcare provider will do a pregnancy test before you start treatment with ixazomib. You should use effective non-hormonal birth control during treatment and for 90 days after your last dose of ixazomib. If using hormonal contraceptives (for example, birth control pills), you should also use an additional barrier method of contraception (for example, diaphragm or condom). Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with ixazomib. Males with female partners who are able to become should use effective birth control during treatment and for 90 days after your last dose of ixazomib. Tell your healthcare provider right away if your partner becomes pregnant or thinks she may be pregnant while you are being treated with ixazomib.


What to do if you missed your ixazomib dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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