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Infliximab-DYYB is available as a 100 mg IV infusion.

Infliximab-DYYB is a biologic DMARD and is used for the following:

• Moderate-to-severe Crohn’s disease (CD)
• Moderate-to-severe ulcerative colitis (UC)
• Moderate-to-severe rheumatoid arthritis (RA)
• Ankylosing spondylitis (AS)
• Psoriatic arthritis (PsA)
• Severe plaque psoriasis (PsO)

Infliximab-DYYB is a biological disease-modifying antirheumatic drug (DMARD) that blocks a protein called tumor necrosis factor (TNF). By blocking TNF, Remicade (infliximab) lowers inflammation in your body to treat symptoms caused by many autoimmune conditions.

Infliximab-DYYB is taken in a cycle of 28 days. For the first 21 days of the cycle, the typical dose is 125 mg taken by mouth once a day. During the last 7 days of the cycle, you won’t take any Ibrance (palbociclib). At the end of the 28 days, the cycle typically starts over again. Your dose might be different if you have liver problems or if you’re taking medications that might interact with Ibrance (palbociclib) (see Pharmacist Tips). You’ll also need to take either an aromatase inhibitor or fulvestrant (Faslodex) for treatment. In addition, if you’re a male or a female who hasn’t undergone menopause, your provider might also recommend you take a luteinizing hormone-releasing hormone (LHRH) agonist.

Infliximab-DYYB is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. Infliximab-DYYB doses >5 mg/kg in moderate to severe heart failure. (4) Previous severe hypersensitivity reaction to infliximab products, or known
hypersensitivity to inactive components of Infliximab-DYYB or to any murine proteins.

Common side effects of Infliximab-DYYB:

• Infections
• Nausea
• Infusion-related reactions (e.g., headache, flushing, shortness of breath, rash)
• Headache
• Diarrhea
• Stomach pain
• Sore throat
• Cough
• Rash
• Bronchitis
• Indigestion
• Tiredness
• General pain
• Joint pain

Serious side effects are rare with Infliximab-DYYB. Contact your healthcare provider immediately if you experience any of the following.

• Severe or deadly infections: fever, difficulty breathing, diarrhea, weakness, cough, stomach pain, sweating, chills, burning when you urinate, urinating more frequently
• Cancer: loss of appetite, fatigue, lumps on skin, swollen lymph nodes in your neck, armpits, or groin, fatigue, weight loss, nosebleeds, vaginal discharge, pelvic or back pain
• Serious allergic reactions: hives, itching, swelling of face or tongue, difficulty breathing, low blood pressure
• Heart failure: shortness of breath, swelling in the legs, ankles, or feet, irregular heartbeat, unable to exercise, tiredness, weakness
• Stroke: facial drooping on one side, slurred speech, weakness, dizziness, headache, confusion, vision loss
• Heart problems: high blood pressure, fast and irregular heart beat, chest pain, heart attacks
• Liver problems or liver failure: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion
• Low blood cell counts: fever, pale skin, fast heart rate, lightheadedness, blood in your urine or stool
  Drug-induced lupus: chest discomfort or pain, short of breath, joint or muscle pain, rash on cheecks or arms

The following medications may interact with Infliximab-DYYB:

• Use with anakinra or abatacept– increased risk of serious infections

Various FDA-approved generic manufacturers

It is not known if Infliximab-DYYB harms your unborn baby. Infliximab-DYYB should be given to a pregnant woman only if clearly needed. Talk to your doctor about stopping Infliximab-DYYB if you
are pregnant or planning to become pregnant.

• Inflectra