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Imjudo is the brand name for tremelimumab-actl and is available as an IV infusion.

Imjudo is available in the following:
25 mg/1.25 mL (20 mg/mL) solution in a single-dose vial.
300 mg/15 mL (20 mg/mL) solution in a single-dose vial.

Imjudo is a CTLA-4 inhibitor that is used to treat the following:
Hepatocellular carcinoma (liver cancer) that can’t be removed with surgery, together with Imfinzi (durvalumab)
Metastatic non-small cell lung cancer without EGFR or ALK gene changes, together with Imfinzi (durvalumab) and platinum-based chemotherapy

Imjudo is an immune checkpoint inhibitor (immunotherapy). More specifically, it’s an CTLA-4 inhibitor. By blocking CTLA-4, it helps the immune system detect and attack cancer cells.

Your provider will determine your Imjudo treatment schedule based on the cancer type. You’ll also receive other medications, like Imfinzi (durvalumab) and/or chemotherapy, as part of your treatment plan, sometimes even on the days you’re not receiving Imjudo.

Liver cancer (adults who weigh 66 lbs or more): The typical dose is 300 mg infused through the veins (IV) on Day 1 of your first treatment cycle only.

NSCLC (adults who weigh 66 lbs or more): The typical dose is 75 mg infused through the veins (IV) for a maximum of 5 doses.

Cycles 1 to 4: Once every 3 weeks during the first 4 treatment cycles.

Cycle 5: No Imjudo infusion.

Cycle 6: Once on Day 1 of the 6th treatment cycle.

Your dose will be different if your body weight is less than 66 lbs.

Imjudo is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Imjudo:

• Abnormal liver labs
• Lower blood cell counts
• Lower blood sodium levels
• Higher blood sugar
• Lower blood calcium levels
• Higher blood potassium levels
• Abnormal kidney labs
• Rash
• Diarrhea
• Fatigue
• Itching
• Muscle, bone, or joint pain

Serious side effects are rare with Imjudo. Contact your healthcare provider immediately if you experience any of the following.

Immune-related adverse events: trouble breathing, cough, diarrhea, mucus or blood in the stool, stomach pain or cramps, rash
Infusion-related reactions: shortness of breath, itching, chills, flushing, upset stomach, or chest discomfort

There are no major drug interactions listed for Imjudo. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

AstraZeneca

Imjudo can harm your unborn baby. Females who are able to become pregnant:
Your healthcare provider should do a pregnancy test before you start treatment with Imjudo.
You should use an effective method of birth control during your treatment and for 3 months after your last dose of Imjudo. Talk to your healthcare provider about birth control methods that you can use during this time.
Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with Imjudo.

• Tremelimumab