ICLUSIG
Used for Cancer
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Manufactured by Takeda Pharmaceuticals
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
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ICLUSIG Uses, Side Effects, Interactions, Warnings & Dosing
What is ICLUSIG?
ICLUSIG is the brand name for ponatinib and is available as an oral tablet.
What dosages is ICLUSIG available in?
ICLUSIG is available as a 10 mg, 15 mg, 30 mg, and 45 mg oral tablet.
What is ICLUSIG used for?
ICLUSIG is a tyrosine kinase inhibitor and is used for the following:
- Chronic myelogenous leukemia (CML)
- Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL)
How does ICLUSIG work?
ICLUSIG is a tyrosine kinase inhibitor (TKI). It blocks a certain protein in your body called BCR-ABL tyrosine kinase. This protein is found on cancer cells like CML and ALL and not on normal, healthy cells. It causes the cancer cells to grow and multiply. By blocking this protein, ICLUSIG kills cancer cells and stops their spread.
How do I take ICLUSIG?
ICLUSIG is typically started at 45 mg by mouth once daily. This dose might differ if you have liver problems. During treatment, your dose might change based on how your cancer responds to ICLUSIG or if you’re taking certain medications that interact with ICLUSIG.
Is it safe for me to take ICLUSIG?
ICLUSIG is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
ICLUSIG Common Side Effects
Common side effects of ICLUSIG:
- Rash
- Joint pain
- Stomach pain
- Constipation
- High blood pressure
- Tiredness
- Headache
- Dry skin
- Swelling or fluid buildup
- Fever
- Nausea
- Lower appetite
ICLUSIG Serious Side Effects
Serious side effects are rare with ICLUSIG. Contact your healthcare provider immediately if you experience any of the following.
- Blood clots or reduced blood flow problems: chest pain, trouble breathing, weakness on one side of the body, trouble talking, changes in vision, severe headache, leg pain or swelling
- Severe fluid buildup or heart failure: shortness of breath during rest or exercise, rapid weight gain, swelling in your arms or legs, chest pain, tiredness
- Changes in your heart rhythm: fainting, dizziness, chest pain, fast heartbeat
- Liver damage: right-sided stomach pain, tiredness, loss of appetite, yellowing of the skin or eyes
- Serious bleeds: bleeding or bruising that doesn’t stop or go away, large amount of bleeding, blood in the urine, throwing up blood, bloody or black and tarry stool
- Abnormal electrolyte levels and kidney problems: racing heart, muscle cramps or spasms, numbness, dark urine, urinating less than usual
- Problems that affect the brain: headaches, vision problems, seizures
Effects of other drugs, drug classes and over-the-counter products on ICLUSIG
The following medications may interact with ICLUSIG:
- Strong CYP3A Inhibitors: Avoid coadministration or reduce
- ICLUSIG dose if coadministration cannot be avoided.
- Strong CYP3A Inducers: Avoid coadministration.
Who makes ICLUSIG?
Takeda Pharmaceuticals
Is ICLUSIG safe in pregnancy?
ICLUSIG can harm your unborn baby. Your healthcare provider will do a pregnancy test before you start taking ICLUSIG.
If you can become pregnant, use an effective form of birth control during treatment and for 3 weeks after your last dose of ICLUSIG. Tell your healthcare provider right away if you become pregnant or think you might be pregnant during
treatment with ICLUSIG. ICLUSIG may affect your ability to have children. Tell your healthcare provider if this is a concern for you.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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