ICLUSIG
Used for Cancer
NowPatient helps you obtain your ICLUSIG prescription for free or at low-cost. Drug savings programs are suitable for individuals who are insured, don't have insurance or are underinsured and can't afford your medicine.
Manufactured by Takeda Pharmaceuticals
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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ICLUSIG key facts
What is ICLUSIG?
ICLUSIG is the brand name for ponatinib and is available as an oral tablet.
What dosages is ICLUSIG available in?
ICLUSIG is available as a 10 mg, 15 mg, 30 mg, and 45 mg oral tablet.
What is ICLUSIG used for?
ICLUSIG is a tyrosine kinase inhibitor and is used for the following:
- Chronic myelogenous leukemia (CML)
- Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL)
How does ICLUSIG work?
ICLUSIG is a tyrosine kinase inhibitor (TKI). It blocks a certain protein in your body called BCR-ABL tyrosine kinase. This protein is found on cancer cells like CML and ALL and not on normal, healthy cells. It causes the cancer cells to grow and multiply. By blocking this protein, ICLUSIG kills cancer cells and stops their spread.
How do I take ICLUSIG?
ICLUSIG is typically started at 45 mg by mouth once daily. This dose might differ if you have liver problems. During treatment, your dose might change based on how your cancer responds to ICLUSIG or if you’re taking certain medications that interact with ICLUSIG.
Is it safe for me to take ICLUSIG?
ICLUSIG is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
ICLUSIG Common Side Effects
Common side effects of ICLUSIG:
- Rash
- Joint pain
- Stomach pain
- Constipation
- High blood pressure
- Tiredness
- Headache
- Dry skin
- Swelling or fluid buildup
- Fever
- Nausea
- Lower appetite
ICLUSIG Serious Side Effects
Serious side effects are rare with ICLUSIG. Contact your healthcare provider immediately if you experience any of the following.
- Blood clots or reduced blood flow problems: chest pain, trouble breathing, weakness on one side of the body, trouble talking, changes in vision, severe headache, leg pain or swelling
- Severe fluid buildup or heart failure: shortness of breath during rest or exercise, rapid weight gain, swelling in your arms or legs, chest pain, tiredness
- Changes in your heart rhythm: fainting, dizziness, chest pain, fast heartbeat
- Liver damage: right-sided stomach pain, tiredness, loss of appetite, yellowing of the skin or eyes
- Serious bleeds: bleeding or bruising that doesn’t stop or go away, large amount of bleeding, blood in the urine, throwing up blood, bloody or black and tarry stool
- Abnormal electrolyte levels and kidney problems: racing heart, muscle cramps or spasms, numbness, dark urine, urinating less than usual
- Problems that affect the brain: headaches, vision problems, seizures
Effects of other drugs, drug classes and over-the-counter products on ICLUSIG
The following medications may interact with ICLUSIG:
- Strong CYP3A Inhibitors: Avoid coadministration or reduce
- ICLUSIG dose if coadministration cannot be avoided.
- Strong CYP3A Inducers: Avoid coadministration.
Who makes ICLUSIG?
Takeda Pharmaceuticals
Is ICLUSIG safe in pregnancy?
ICLUSIG can harm your unborn baby. Your healthcare provider will do a pregnancy test before you start taking ICLUSIG.
If you can become pregnant, use an effective form of birth control during treatment and for 3 weeks after your last dose of ICLUSIG. Tell your healthcare provider right away if you become pregnant or think you might be pregnant during
treatment with ICLUSIG. ICLUSIG may affect your ability to have children. Tell your healthcare provider if this is a concern for you.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my ICLUSIG prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your ICLUSIG prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient ICLUSIG savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient ICLUSIG savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for ICLUSIG | Canadian Prescription Savings* for ICLUSIG | ICLUSIG Drug Coupon* | ICLUSIG Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of ICLUSIG?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for ICLUSIG | Canadian Prescription Savings* for ICLUSIG | ICLUSIG Drug Coupon* | ICLUSIG Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the ICLUSIG savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the ICLUSIG drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for ICLUSIG, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the ICLUSIG prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, ICLUSIG is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed ICLUSIG for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the ICLUSIG prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the ICLUSIG prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for ICLUSIG
If you are having trouble paying for your ICLUSIG medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for ICLUSIG you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- ICLUSIG is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers ICLUSIG
- If ICLUSIG is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for ICLUSIG
If you are having trouble paying for your ICLUSIG medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for ICLUSIG you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers ICLUSIG
- If ICLUSIG is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for ICLUSIG
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your ICLUSIG treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for ICLUSIG you will need to meet the following criteria:
- You must be currently insured and have coverage for ICLUSIG
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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