Used for Cancer

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Navin Khosla NowPatientGreen tick
Updated on 24 Apr 2024

gilteritinib Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is gilteritinib available in?

What dosages is gilteritinib available in?

gilteritinib is available as a 40 mg oral tablet.

What is gilteritinib used for?

What is gilteritinib used for?

gilteritinib is a kinase inhibitor indicated for the treatment of adult patients who have relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation as detected by an FDA-approved test.

How does gilteritinib work?

How does gilteritinib work?

gilteritinib works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

How do I take gilteritinib?

How do I take gilteritinib?

gilteritinib is typically given as 120 mg by mouth once daily.

Is it safe for me to take gilteritinib?

Is it safe for me to take gilteritinib?

gilteritinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

gilteritinib Common Side Effects

gilteritinib Common Side Effects

Common side effects of gilteritinib:

  • Increased transaminase
  • Joint/muscle pain
  • Fatigue/malaise
  • Fever
  • Edema
  • Rash
  • Diarrhea
  • Shortness of breath
  • Nausea
  • Cough
  • Constipation
  • Headache
  • Dizziness
  • Vomiting
  • Low blood pressure
gilteritinib Serious Side Effects

gilteritinib Serious Side Effects

Serious side effects are rare with gilteritinib. Contact your doctor right away if you experience:

  • Posterior Reversible Encephalopathy Syndrome (PRES): Seizure or quickly worsening symptoms such as headache, decreased alertness, confusion, reduced eyesight, blurred vision, or other visual problems
  • QTc prolongation: Can cause irregular heartbeats that can be life-threatening. Tell your healthcare provider right away if you feel dizzy, lightheaded, or faint
  • Inflammation of the pancreas (pancreatitis). Tell your healthcare provider right away if you have severe stomach (abdomen) pain that does not go away. This pain may happen with or without nausea and vomiting
Effects of other drugs, drug classes and over-the-counter products on gilteritinib

Effects of other drugs, drug classes and over-the-counter products on gilteritinib

The following medications may interact with gilteritinib:

  • Combined P-gp and Strong CYP3A Inducers: Avoid concomitant use
  • Strong CYP3A Inhibitors: Consider alternative therapies. If the concomitant use of strong CYP3A inhibitors cannot be avoided, monitor patients more frequently for gilteritinib adverse reactions
  • P-gp, BCRP, OCT1 Substrates: Decrease the dose of the substrates when coadministered with gilteritinib and as clinically indicated
Who makes gilteritinib?

Who makes gilteritinib?

Various FDA-approved generic manufacturers

Is gilteritinib safe in pregnancy?

Is gilteritinib safe in pregnancy?

gilteritinib can cause harm to your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with gilteritinib. If you are able to become pregnant, your healthcare provider may perform a pregnancy test 7 days before you start treatment with gilteritinib. Females who are able to become pregnant should use effective birth control (contraception) during treatment with gilteritinib and for 6 months after the last dose of gilteritinib. Males who have female partners that are able to become pregnant should use effective birth control
(contraception) during treatment with gilteritinib and for 4 months after the last dose of gilteritinib.


What to do if you missed your gilteritinib dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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