FluphenazinePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Fluphenazine HCl
    Generic for Permitil
    34 tablets $44.4 USD
    Save $256.84
  3. Fluphenazine HCl
    Generic for Permitil
    30 tablets $39.3 USD
    Save $226.50
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Save up to 90% of your branded or generic medications using the Now Patient Rx Advantage Card

Do you need a prescription for fluphenazine?

Yes, fluphenazine is only available with a valid physician Rx.

How much is fluphenazine without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase fluphenazine, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for fluphenazine in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a fluphenazine savings card?

Yes. Save up to 90% on your fluphenazine with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a fluphenazine coupon provider in the US?

No. Now Patient does not provide fluphenazine coupons or FREE fluphenazine samples.

Do you accept commercial, Medicare or Medicaid coverage for fluphenazine in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much fluphenazine?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using fluphenazine. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much fluphenazine. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

US brand name of fluphenazine and manufacturer

Fluphenazine is available in the US under various brand names, including Prolixin and fluphenazine Hydrochloride (HCl). It is manufactured by multiple pharmaceutical companies.

UK brand name of fluphenazine and manufacturer

Fluphenazine is available in the UK under the brand name Modecate. It is manufactured by GlaxoSmithKline UK.

Is fluphenazine available in the UK on the NHS?

Yes, fluphenazine is available on the NHS in the UK. It can be prescribed by healthcare professionals for eligible patients.

Prescription requirement for fluphenazine

Fluphenazine is a prescription medication and requires a prescription from a healthcare provider.

FDA approval of fluphenazine

Fluphenazine has received FDA approval for the treatment of various psychiatric conditions, including schizophrenia, bipolar disorder, and severe behavioral problems in children.

Active ingredient of fluphenazine and mechanism of action

Fluphenazine is a phenothiazine antipsychotic drug used for mental health conditions. The active ingredient in fluphenazine is fluphenazine hydrochloride. It works by blocking the action of dopamine, a neurotransmitter in the brain that is associated with psychotic symptoms. By blocking dopamine receptors, fluphenazine helps reduce symptoms such as hallucinations, delusions, and disorganized thinking.

Uses of fluphenazine

Treatment of schizophrenia: Fluphenazine is an antipsychotic medication used in the treatment of schizophrenia. It helps manage symptoms such as psychosis and anxiety, by balancing dopamine levels in the brain.

Management of bipolar disorder: Fluphenazine can also be utilized for managing bipolar disorder. By stabilizing mood swings and reducing episodes of mania or depression, it aids in the long-term management of this chronic condition. Some common side effects may include dry mouth, tiredness, and weakness.

Forms of fluphenazine

Fluphenazine is available in various forms, including oral tablets, oral liquid concentrate, and injectable formulations. The specific form and strength will depend on the intended use and the formulation of the medication.

Dosage of fluphenazine

The dosage of fluphenazine will vary depending on the specific condition being treated, individual patient characteristics, and response to therapy. It is important to follow the dosage instructions provided by your healthcare provider.

If you miss a dose of fluphenazine, take it as soon as you remember, unless it is closer to the time of your next dose. Do not double your next dose or take more than what is prescribed. Missing doses of fluphenazine may increase your risk of relapse in your symptoms.

Store at room temperature protected from light. Store in a dry place. Do not store in a bathroom.

Precautions and warnings for fluphenazine

  • Fluphenazine may cause drowsiness, dizziness, or blurred vision. Use caution when engaging in activities that require alertness until you know how fluphenazine affects you
  • As fluphenazine treatment can worsen glaucoma, this medication is contraindicated in patients with known or suspected narrow-angle glaucoma
  • Fluphenazine may increase blood pressure in individuals with pheochromocytoma, a rare tumor of the adrenal glands. It is important to monitor blood pressure closely in individuals with this condition if they are taking fluphenazine
  • It may interact with other medications, so it is important to inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements
  • Fluphenazine may have an increased risk of side effects in elderly patients, so careful monitoring is necessary
  • Avoid sudden discontinuation of fluphenazine, as it may lead to withdrawal symptoms or a return of psychotic symptoms
  • Fluphenazine is not recommended for use during pregnancy as it may cause harm to the unborn baby. It is also not recommended for use while breastfeeding as it can pass into breast milk and affect the nursing infant
  • Fluphenazine should be used with caution in pediatric patients due to potential adverse effects on growth, development, and behavior
  • You should not use this medicine if you are allergic to fluphenazine or other phenothiazines such as chlorpromazine, perphenazine

Side effects of fluphenazine

Common side effects of fluphenazine may include:

  • Drowsiness
  • Dizziness
  • Dry mouth
  • Constipation
  • Blurred vision

Serious side effects:

  • Fluphenazine can cause various neurological side effects, including dystonia (muscle spasms), akathisia (restlessness), and tardive dyskinesia (involuntary movements of the face and body)
  • Fluphenazine has the potential to cause cardiovascular side effects, such as orthostatic hypotension (a drop in blood pressure upon standing), tachycardia (rapid heart rate), and arrhythmias (abnormal heart rhythms)
  • Fluphenazine can lead to various metabolic changes, including weight gain, hyperlipidemia (elevated blood lipid levels), and hyperglycemia (high blood sugar levels). These effects may increase the risk of developing conditions like diabetes, high cholesterol, and obesity
  • A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction such as a rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing

Contact your healthcare provider if you experience severe or persistent side effects.

Drug interactions

There is a potential risk of adverse reactions when taking fluphenazine with other medications. Here are some potential drug interactions of fluphenazine:

  • Central nervous system (CNS) depressants: Combining fluphenazine with other CNS depressants like alcohol, sedatives, tranquilizers, or opioids can increase the risk of excessive sedation, drowsiness, and respiratory depression. It is essential to use caution when taking these medications concurrently
  • Anticholinergic drugs: Fluphenazine has anticholinergic properties, meaning it can block the action of acetylcholine in the body. When combined with other anticholinergic drugs such as certain antihistamines, tricyclic antidepressants, or medications for Parkinson’s disease, it can enhance the anticholinergic effects, leading to symptoms like dry mouth, constipation, blurred vision, and urinary retention
  • QT prolonging drugs: Fluphenazine can cause QT interval prolongation, which can increase the risk of developing an irregular heartbeat. Combining it with other medications that also have this potential effect, such as certain antibiotics, antiarrhythmics, or antifungals, can further increase this risk. It is important to closely monitor patients who are taking both fluphenazine and QT prolonging drugs
  • Dopamine agonists: Fluphenazine works by blocking dopamine receptors in the brain. Combining it with dopamine agonists, which stimulate dopamine receptors, can counteract the effects of both medications and reduce their effectiveness. This can be problematic for individuals with Parkinson’s disease who may be taking both fluphenazine and dopamine agonists
  • Antidepressants: Certain antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), can increase the levels of fluphenazine in the body. This can potentially lead to an increased risk of side effects, such as extrapyramidal symptoms (EPS) or neuroleptic malignant syndrome (NMS). Close monitoring is necessary when combining fluphenazine with antidepressants

It is important to note that this list is not exhaustive, and there may be other potential drug interactions with fluphenazine. Therefore, it is crucial for individuals taking fluphenazine to inform their healthcare providers about all medications, including over-the-counter drugs and supplements, that they are taking. This will help ensure the safe and effective use of fluphenazine and minimize the risk of drug interactions.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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