FludrocortisonePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Fludrocortisone Acetate
    Generic for Florinef
    30 tablets $11.4 USD
    Save $13.80
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Do you need a prescription for fludrocortisone?

Yes, fludrocortisone is only available with a valid physician Rx.

How much is fludrocortisone without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase fludrocortisone, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for fludrocortisone in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a fludrocortisone savings card?

Yes. Save up to 90% on your fludrocortisone with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a fludrocortisone coupon provider in the US?

No. Now Patient does not provide fludrocortisone coupons or FREE fludrocortisone samples.

Do you accept commercial, Medicare or Medicaid coverage for fludrocortisone in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much fludrocortisone?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using fludrocortisone. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much fludrocortisone. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic fludrocortisone?

Generic fludrocortisone refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of fludrocortisone

Fludrocortisone is approved by the U.S. Food and Drug Administration (FDA) for the treatment of various conditions, including adrenal insufficiency and salt-losing adrenogenital syndrome.

Active ingredient of fludrocortisone

The active ingredient of fludrocortisone is fludrocortisone acetate.

US brand name of fludrocortisone and manufacturer

Fludrocortisone is available in the US under the brand name Florinef. The manufacturer is Bristol-Myers Squibb Company.

UK brand name of fludrocortisone and manufacturer

In the UK, fludrocortisone is available under the brand name Florinef Acetate. The manufacturer is Bristol-Myers Squibb Pharmaceuticals Limited.

Prescription requirement for fludrocortisone

A prescription (Rx) is required for fludrocortisone in both the US and the UK.

Availability of fludrocortisone in the UK with NHS prescription

Fludrocortisone is available in the UK with an NHS prescription.

Conditions treated by fludrocortisone

Fludrocortisone is a steroid drug. It acts as both a glucocorticoid and a mineralocorticoid. It is primarily used to replace or supplement the hormone aldosterone, which helps regulate sodium levels in the body. Fludrocortisone is commonly prescribed for conditions such as adrenal insufficiency (Addison’s disease) and salt-losing adrenogenital syndrome.

How does fludrocortisone work?

Fludrocortisone is a medication that belongs to a class of drugs called corticosteroids. It mimics the effects of naturally occurring hormones in the body, specifically aldosterone.

Aldosterone is a hormone produced by the adrenal glands that regulates the balance of salt and water in the body. It helps to maintain blood pressure, control electrolyte levels, and regulate the balance of fluids in the body.

Fludrocortisone acts as a synthetic aldosterone, binding to the mineralocorticoid receptors in the kidneys. By activating these receptors, it increases the reabsorption of sodium and the excretion of potassium in the kidneys. This leads to an overall increase in the retention of salt and water in the body.

By increasing salt and water retention, fludrocortisone helps to regulate blood pressure and electrolyte levels.

Forms of fludrocortisone available

Fludrocortisone is available in oral tablet form.

Dosage of fludrocortisone

The dosage of fludrocortisone may vary depending on the individual patient and the specific condition being treated. It is important to follow the recommended dosage instructions provided by the healthcare provider.

Directions for fludrocortisone use

Fludrocortisone should be taken as directed by the healthcare provider. The specific instructions may include the timing of administration, dosage adjustments, and any necessary precautions.
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Store at room temperature away from moisture, heat, and light.

Is fludrocortisone safe to take if I am breastfeeding?

Fludrocortisone can pass into breast milk, and its use during breastfeeding may not be recommended. It is important to consult with a healthcare provider before using fludrocortisone while breastfeeding to evaluate any potential risks or concerns.

Is it safe to take fludrocortisone if I am pregnant or planning on becoming pregnant?

Fludrocortisone should be used during pregnancy only if the potential benefits outweigh the potential risks. If you are pregnant or planning to become pregnant, it is important to discuss the potential risks and benefits with your healthcare provider before using fludrocortisone.

What are the side effects of fludrocortisone?

Common side effects of fludrocortisone may include increased blood pressure, swelling or fluid retention, headache, dizziness, muscle weakness, and gastrointestinal symptoms such as nausea and stomach upset.

Some individuals may also experience changes in appetite, weight gain, sleep disturbances, mood changes, and skin reactions such as rash or itching. It is important to note that these side effects are not experienced by everyone and may vary from person to person. Additionally, long-term use of fludrocortisone or higher doses may increase the risk of more serious side effects such as osteoporosis, diabetes, cataracts, and adrenal suppression.

Get emergency medical advice and help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

It is important to discuss any concerns or potential adverse effects with a healthcare professional before starting or adjusting fludrocortisone treatment.

Warnings and precautions for fludrocortisone

  • Fludrocortisone may interact with certain medications and medical conditions. It is important to inform the healthcare provider about all medications and supplements you are taking and any existing medical conditions to avoid potential complications
  • The dosage of fludrocortisone may need to be adjusted during times of stress, such as illness, surgery, or trauma. It is important to follow the guidance of the healthcare provider in such situations
  • Fludrocortisone can impair the function of vaccines. Therefore, vaccines should not be given while patients are using fludrocortisone
  • You should not use fludrocortisone if you have a fungal infection anywhere in your body
  • Prolonged use of fludrocortisone may lead to adrenal insufficiency, where the adrenal glands fail to produce enough cortisol, resulting in a dependency on the medication
  • Excessive use or improper monitoring can lead to fluid retention, edema, high blood pressure, and electrolyte imbalances such as low potassium levels
  • If you have diabetes, this drug may make it harder to control your blood sugar levels. Monitor your blood sugar levels regularly and inform your doctor of the results
  • Prolonged use of fludrocortisone can increase the risk of osteoporosis, a condition characterized by weakened bones, and subsequent bone fractures. Regular monitoring of bone health and appropriate calcium and vitamin D supplementation may help prevent or manage this risk
  • Long-term use of fludrocortisone may increase the risk of developing glaucoma, a condition characterized by increased pressure in the eyes, and cataracts, which cause clouding of the eye’s lens. Regular eye exams and monitoring are important for early detection and management of these conditions

It is important to note that these risks are not exhaustive, and individual experiences may vary. It is crucial to follow your healthcare provider’s instructions and report any concerning symptoms or side effects while taking fludrocortisone.

Drug interactions with fludrocortisone

There are potential food and drug interactions with fludrocortisone. It is important to consult with your doctor or pharmacist before starting or stopping any medications or making changes to your diet while taking fludrocortisone.

Food interactions: Certain foods, particularly those high in sodium, may increase the risk of water retention and high blood pressure (hypertension) when taken with fludrocortisone. It is advisable to maintain a balanced diet and to limit excessive intake of sodium-rich foods.

Drug interactions: Fludrocortisone may interact with several medications, including but not limited to:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or aspirin: These medications may increase the risk of stomach bleeding or ulceration when taken concurrently with fludrocortisone
  • Potassium supplements or medications that increase potassium levels: Fludrocortisone can cause the body to retain sodium and excrete potassium, so taking additional potassium supplements or medications may lead to high potassium levels in the blood
  • Combining fludrocortisone with certain diuretics may increase the risk of electrolyte imbalances, particularly high potassium levels

It is important to inform your doctor about all medications, supplements, and vitamins you are taking before starting fludrocortisone. They can provide guidance on any potential interactions and adjust your medication or dosages if necessary.

What other drugs are similar to fludrocortisone?

Hydrocortisone is a corticosteroid medication that is used to treat various conditions, including adrenal insufficiency. It has similar anti-inflammatory and immunosuppressant effects as fludrocortisone

It is important to note that while these drugs may be similar to fludrocortisone in terms of their mechanism of action, they may have different dosing regimens, side effects, and specific uses.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

About Now Patient

Now Patient’s online services are available in the US and UK. We help you manage your prescriptions, doctor appointments, test results, health risks, and a lot more, all in one place for FREE. If you are in the United States, you could enjoy savings using Now Patient’s mail-order pharmacy or use the Now Patient Rx Advantage Card at over 65,000 pharmacies, with savings of up to 90% on popular FDA-approved brand and generic medications like Ozempic, Mounjaro, clopidogrel and lots more. We do not currently handle commercial insurance, Medicare or Medicaid. UK NHS and private prescriptions are delivered FREE of charge across England & Wales by our UK NHS online pharmacy.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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