Flucytosine Generic

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Flucytosine
    Generic for Ancobon
    46 capsules $407.1 USD
    Save $1404.84
  3. Flucytosine
    Generic for Ancobon
    30 capsules $265.8 USD
    Save $915.90
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Do you need a prescription for flucytosine?

Yes, flucytosine is only available with a valid physician Rx.

How much is flucytosine without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase flucytosine, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for flucytosine in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a flucytosine savings card?

Yes. Save up to 90% on your flucytosine with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a flucytosine coupon provider in the US?

No. Now Patient does not provide flucytosine coupons or FREE flucytosine samples.

Do you accept commercial, Medicare or Medicaid coverage for flucytosine in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much flucytosine?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using flucytosine. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much flucytosine. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic flucytosine?

Generic flucytosine refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of flucytosine

Flucytosine is approved by the U.S. Food and Drug Administration (FDA) for the treatment of certain fungal infections.

Active ingredient of flucytosine

The active ingredient of flucytosine is flucytosine.

US brand names of flucytosine and manufacturers

Flucytosine is available under the brand name Ancobon in the US. The medication is manufactured by various pharmaceutical companies.

UK brand names of flucytosine and manufacturers

In the UK, flucytosine is available under the brand name Ancotil. The manufacturer may vary depending on the brand name.

Prescription requirement for flucytosine

A prescription (Rx) is required for flucytosine in both the US and the UK.

Availability of flucytosine in the UK with NHS prescription

Flucytosine is available in the UK with an NHS prescription.

Conditions treated by flucytosine

Flucytosine is primarily used in the treatment of serious fungal infections, such as cryptococcal meningitis and systemic candidiasis.

How does flucytosine work?

Flucytosine is an antimetabolite antifungal drug, also known as 5-fluorocytosine. It is an antifungal medication used in the treatment of fungal infections. Its mechanism of action involves the conversion of flucytosine into 5-fluorouracil within the fungal cells.

Once inside the fungal cell, flucytosine is taken up by the fungal cytosine permease transporter. Enzymes within the fungal cell then convert flucytosine into 5-fluorouracil, which is further metabolized into 5-fluorouridine triphosphate (5-FUTP) and 5-fluorodeoxyuridine triphosphate (5-FdUTP).

These metabolites interfere with fungal RNA and DNA protein synthesis by inhibiting the enzymatic activity of thymidylate synthase and RNA synthetase, respectively. This disruption of nucleic acid synthesis ultimately leads to the inhibition of fungal cell growth and replication, leading to the death of the fungal cells.

It is important to note that flucytosine is primarily used as combination therapy with other antifungal medications, such as amphotericin B, to enhance its efficacy and reduce the risk of drug resistance.

Forms of flucytosine available

Flucytosine is available in the form of oral capsules.

Dosage of flucytosine

The dosage of flucytosine may vary depending on the specific fungal infection being treated, the severity of the infection, and individual patient factors. It is important to follow the prescribed dosage instructions provided by the healthcare provider.

Directions for flucytosine use

Flucytosine should be taken exactly as directed by the healthcare provider. The capsules should be swallowed whole with water. It is important to complete the full course of treatment, even if the symptoms improve before the completion of the prescribed duration.

Warnings and precautions for flucytosine

  • Flucytosine should be used with caution in individuals with impaired renal function or a history of bone marrow suppression
  • Flucytosine is broken down by the liver, so individuals with liver disease or impairment should exercise caution while taking this medication. Dose adjustments may be necessary in such cases
  • Flucytosine’s use requires monitoring and extreme caution in patients with hepatic, renal, and hematologic insufficiency
  • Closely monitoring patients taking flucytosine is essential to ensure their safety and efficacy during treatment for fungal infections caused by Candida or Cryptococcus species
  • Like other antifungal medications, the development of resistance to flucytosine is possible. It is important to complete the full course of treatment as prescribed by your healthcare provider to minimize the risk of relapse
  • It may interact with certain medications, including other antifungal agents, certain chemotherapy drugs, and medications that affect kidney function. It is important to inform the healthcare provider about all medications being taken

Drug interactions

Flucytosine is contraindicated with certain immunosuppressant drugs, anticoagulants, anticonvulsant drugs and antibiotics. Always speak to your healthcare provider about the drugs you are taking.

Use of flucytosine during pregnancy

The use of flucytosine during pregnancy should be carefully considered, and the potential risks and benefits should be discussed with a healthcare provider.

Use of flucytosine while breastfeeding

Flucytosine may pass into breast milk, and its use during breastfeeding is generally not recommended. Consultation with a healthcare provider is necessary to assess the potential risks and benefits.

Possible side effects of flucytosine

Common side effects of flucytosine include gastrointestinal disturbances, such as nausea and vomiting, as well as diarrhea. Skin rashes and allergic reactions may also occur. It is important to monitor for more serious adverse effects, such as bone marrow suppression or liver toxicity. In case of these potentially serious side effects, medical attention should be sought immediately. To manage the side effects of flucytosine, it is crucial to adhere to the prescribed dosing schedule and avoid drug interactions with other antimycotic drugs like amphotericin B.

Similar drugs to flucytosine

Other antifungal medications used to treat fungal infections include fluconazole, itraconazole, and amphotericin B.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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