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Ethionamide is available as a 250 mg oral tablet.

Ethionamide is an antitubercular agent that is used to treat:
Tuberculosis (TB) that is resistant (doesn’t respond to) to first-choice anti-TB antibiotics (e.g., isoniazid or rifampin (Rifadin))
TB infection in people who can’t take other anti-TB antibiotics

Ethionamide is an antitubercular agent. It prevents TB bacteria from making the building blocks they need to multiply and survive.

Ethionamide is dosed as follows:

• Adults: Take 15 to 20 mg/kg by mouth once daily. The dose can be divided into 2 or 3 times a day to prevent upset stomach. The maximum daily dose is 1,000 mg. Your provider will start you at 250 mg daily, then slowly raise the dose to your goal weight-based dose or until you can no longer tolerate the medication
• Children: Take 10 to 20 mg/kg by mouth once daily in 2 or 3 divided doses after meals. It can also be taken as 15 mg/kg as a single dose every 24 hours

Ethionamide is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have severe hepatic impairment and in patients who are hypersensitive to the drug.

Common side effects of Ethionamide:

• Upset stomach
• Nausea
• Vomiting
• Diarrhea
• Stomach pain
• Extra saliva
• Metallic taste in the mouth
• Swelling or sores inside the mouth
• Poor appetite

Serious side effects are rare with Ethionamide. Contact your healthcare provider immediately if you experience any of the following.

• Serious skin reaction

The following medications may interact with Ethionamide:

• Ethionamide has been found to temporarily raise serum concentrations of isoniazid. Ethionamide may potentiate the adverse effects of other anti-tuberculous drugs administered concomitantly. In particular, convulsions have been reported when Ethionamide is administered with cycloserine and special care should be taken when the treatment regimen includes both of these drugs. Excessive ethanol ingestion should be avoided because a psychotic reaction has been reported

Various FDA-approved generic manufacturers

It is also not known whether Ethionamide can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Ethionamide should be given to a pregnant woman only if clearly needed.

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