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Esomeprazole is available as a 20 mg and 40 mg delayed-release capsule and 2.5 mg, 5 mg, 10 mg, 20 mg, and 40 mg delayed-release oral suspension.

Esomeprazole is a proton pump inhibitor that is used to treat:

• Heartburn — OTC only
• Lower the risk of stomach ulcer due to nonsteroidal anti-inflammatory drugs (NSAID)
• Lower the risk of duodenal ulcer caused by Helicobacter pylori (H. pylori) infection
• Other medical conditions that cause too much stomach acid (e.g., Zollinger-Ellison syndrome)

Esomeprazole is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach by blocking the final step of stomach acid production. This helps relieve heartburn and other stomach problems.

Esomeprazole is typically taken as 20 mg to 40 mg by mouth once daily. Dosing for children will depend on the child’s weight, age, and the reason they’re taking the medication.

Esomeprazole is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a known hypersensitivity to proton pump inhibitors (PPIs) (angioedema and anaphylaxis have occurred.

Common side effects of Esomeprazole:

• Headache
• Belly pain
• Diarrhea
• Nausea
• Passing gas
• Constipation
• Dry mouth

Serious side effects are rare with Esomeprazole. Contact your healthcare provider immediately if you experience any of the following.

• Severe stomach pain or diarrhea
• Kidney problems: urinating more or less than usual, fever, poor appetite
• Lupus symptoms: joint pain, skin rash on arms or cheeks that gets worse in the sunlight
• Serious skin reactions: blistering, peeling, or bleeding skin, fever, chills

The following medications may interact with Esomeprazole:

• May affect plasma levels of antiretroviral drugs; use with atazanavir and nelfinavir is not recommended; if saquinavir is used with Esomeprazole, monitor for toxicity and consider saquinavir dose reduction
• May interfere with drugs for which gastric pH affects bioavailability (e.g., ketoconazole, iron salts, erlotinib, digoxin and mycophenolate mofetil). Patients treated with Esomeprazole and digoxin may need to be monitored for digoxin toxicity
• Combined inhibitor of CYP 2C19 and 3A4 may raise Esomeprazole levels.Clopidogrel: Esomeprazole decreases exposure to the active metabolite of clopidogrel
• May increase systemic exposure of cilostazol and an active metabolite. Consider dose reduction.
• Tacrolimus: Esomeprazole may increase serum levels of tacrolimus
• Methotrexate: Esomeprazole may increase serum levels of methotrexate

Various FDA-approved generic manufacturers

Esomeprazole may cause harm to your unborn baby based on animal studies. You should talk to your healthcare provider before taking this medication if you are pregnant.

• Nexium