EsomeprazolePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  1. Medication
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  2. Esomeprazole
    Generic for Nexium
    30 capsules $6 USD
    Save $210.60
  3. Esomeprazole
    Generic for Nexium
    30 capsules $6 USD
    Save $210.60
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Save up to 90% of your branded or generic medications using the Now Patient Rx Advantage Card

Do you need a prescription for esomeprazole?

Yes, esomeprazole is only available with a valid physician Rx.

How much is esomeprazole without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase esomeprazole, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for esomeprazole in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a esomeprazole savings card?

Yes. Save up to 90% on your esomeprazole with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a esomeprazole coupon provider in the US?

No. Now Patient does not provide esomeprazole coupons or FREE esomeprazole samples.

Do you accept commercial, Medicare or Medicaid coverage for esomeprazole in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much esomeprazole?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using esomeprazole. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much esomeprazole. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic esomeprazole?

US brand name of esomeprazole and manufacturer

Esomeprazole is available in the US under the brand name Nexium. It is manufactured by AstraZeneca.

UK brand name of esomeprazole and manufacturer

In the UK, esomeprazole is available under the brand name Nexium. It is also manufactured by AstraZeneca.

Prescription requirement for esomeprazole

Esomeprazole is available only by prescription and should be used under the guidance of a healthcare professional.  In the UK, esomeprazole 20mg is available over-the-counter as Nexium Control.

FDA approval of esomeprazole

Esomeprazole has received FDA approval for the treatment of various conditions, including gastroesophageal reflux disease (GERD), stomach ulcers, and Helicobacter pylori infection.

Is esomeprazole available in the UK on NHS?

Esomeprazole is available on the NHS in the UK, and a prescription is required to obtain it.  The 20mg strength is available over-the-counter.

Active ingredient of esomeprazole and mechanism of action

Esomeprazole magnesium belongs to a class of medications known as proton pump inhibitors (PPIs). It contains the active ingredient esomeprazole, which works by reducing the production of stomach acid. This helps to relieve symptoms of acid reflux and promote healing of stomach ulcers.

Uses of esomeprazole

Esomeprazole is used in patients who have the following conditions:

  • Gastroesophageal reflux disease (GERD): to reduce symptoms such as heartburn and acid regurgitation
  • Zollinger-Ellison syndrome: to reduce the amount of acid produced by the stomach
  • Stomach ulcers: to promote healing and prevent recurrence
  • Helicobacter pylori (H. pylori) infection: in combination with amoxicillin and clarithromycin to eradicate the infection
  • To decrease the chance of developing gastric ulcers when taking nonsteroidal anti-inflammatory drugs (NSAIDs)

Forms of esomeprazole

Esomeprazole is available in various dosage forms, including delayed-release capsules and oral suspension.

Dosage of esomeprazole

The dosage of esomeprazole will vary depending on the condition being treated and individual factors. It is important to follow the dosage instructions provided by your healthcare provider.

Precautions and warnings for esomeprazole

  • Esomeprazole may interact with certain medications, including clopidogrel and certain antifungal agents. It is important to inform your healthcare provider about all the medications you are taking
  • Long-term use of esomeprazole may increase the risk of bone fractures, particularly in older adults. Your healthcare provider may monitor your bone health if long-term treatment is necessary
  • Tell your doctor if you have low levels of magnesium, calcium, potassium, vitamin B12, osteoporosis, or liver disease
  • It is not known if esomeprazole passes into breast milk. Speak to your doctor before breast-feeding

Side effects of esomeprazole

Common side effects of esomeprazole may include headache, joint pain, dry mouth, and gastrointestinal side effects such as constipation, stomach pain, diarrhea, and nausea. Serious side effects are rare but may include allergic reactions, severe stomach pain, and liver problems. Seek medical attention if you experience any severe or concerning side effects. Get medical help right away if you have an allergic reaction. Symptoms include hives, trouble breathing, swelling of your face, tongue or throat, skin rash, and blistering or peeling of the skin. Promptly report any adverse effects to a healthcare provider.

Interactions with other drugs

Esomeprazole may interact with certain medications, including warfarin, atazanavir, cilostazol, citalopram, clopidogrel, diazepam, digoxin, erlotinib, itraconazole, ketoconazole, voriconazole, methotrexate, nelfinavir, phenytoin, rifampin, St John’s wort, rilpivirine or tacrolimus. It is important to inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter (OTC) drugs, dietary supplements, multivitamins, and herbal products, to avoid any adverse effects and potential drug interactions.

Similar drugs to esomeprazole

Other drugs similar to esomeprazole include omeprazole, pantoprazole, lansoprazole, and rabeprazole.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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