How can I lower the cost of my esketamine

You can lower cost of your esketamine using one of the 4 following drug savings programs: Rx Advantage Card for esketamine, Canadian Prescription Savings for esketamine, esketamine Drug Coupons, esketamine Patient Assistance Programs

esketamine Coupon, Savings Card and Patient Assistance

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esketamine

Used for Depression

Are you tired of high medication costs? Our service offers unbeatable savings on your esketamine prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.

Manufactured by various FDA-approved generic manufacturers.

*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.

This content is intended for US audiences only

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esketamine Uses, Side Effects, Interactions, Warnings & Dosing

Medically reviewed by Navin Khosla, B.Pharm

Written by Rajive Patel, B.Pharm

What dosages is esketamine available in?

esketamine is available as 28 mg of esketamine per device. Each nasal spray device delivers two sprays containing a total of 28 mg of esketamine.

What is esketamine used for?

esketamine is a NMDA receptor antagonist and is used for the following:

Treatment-resistant depression (TRD) in adults
Major depressive disorder in adults with suicidal ideation or behavior (MDSI)

How does esketamine work?

esketamine is a N-methyl-D-aspartate (NMDA) receptor antagonist. It’s not exactly known how the medication works to help with depression. But it’s thought to balance the chemicals and signaling pathways in your brain that are involved with regulating your mood.

How do I take esketamine?

esketamine is given as a spray into the nose at a provider’s treatment center. Each device contains 1 spray for each nostril and a total of 28 mg of esketamine.

esketamine is typically used along with an antidepressant that’s taken by mouth

Treatment-resistant depression (TRD):

Weeks 1 to 4: The typical starting dose is 56 mg sprayed into the nose on day 1. After the first day, the dose is 56 mg or 84 mg twice per week.
Weeks 5 to 8: The typical dose is 56 mg or 84 mg sprayed into the nose once per week
Week 9 and beyond: The typical dose is 56 mg or 84 mg sprayed into the nose once every week or every other week, depending on how you respond to the medication
Major depressive disorder with suicidal ideation or behavior (MDSI): The recommended dose is 84 mg sprayed into the nose twice per week for 4 weeks (1 month). The dose can be lowered to 56 mg twice per week if you’re having side effects. After 1 month of treatment, your provider will decide whether you should continue treatment with esketamine based on how well you’re responding to the medication

Is it safe for me to take esketamine?

esketamine is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

Aneurysmal vascular disease (including thoracic and abdominal aorta, intracranial and peripheral arterial vessels) or arteriovenous malformation.
Intracerebral hemorrhage
Hypersensitivity to esketamine, ketamine, or any of the excipients

esketamine Common Side Effects

Common side effects of esketamine:

Dissociation
Dizziness
Nausea
Sleepiness
Vertigo
Headache
Changes in taste
Numbness
Anxiety
Feeling sluggish
Higher blood pressure

esketamine Serious Side Effects

Serious side effects are rare with esketamine. Contact your healthcare provider immediately if you experience any of the following.

Extreme sleepiness
Dangerously slow breathing: trouble breathing; bluish-colored lips, fingers, or toes
Suicidal thoughts and behaviors: anxiety, panic attacks, difficulty sleeping, feeling angry or irritated, restlessness
Extremely high blood pressure: chest pain, shortness of breath, severe headache, visual changes

Effects of other drugs, drug classes and over-the-counter products on esketamine

The following medications may interact with esketamine:

Concomitant use with CNS depressants (e.g., benzodiazepines, opioids, alcohol) may increase sedation. Closely monitor for sedation with concomitant use of esketamine with CNS depressants
Concomitant use with psychostimulants (e.g., amphetamines, methylphenidate modafinil, armodafinil) may increase blood pressure. Closely monitor blood pressure with concomitant use of
esketamine with psychostimulants
Concomitant use with monoamine oxidase inhibitors (MAOIs) may increase blood pressure. Closely monitor blood pressure with concomitant use of esketamine with MAOIs

Who makes esketamine?

Various FDA-approved generic manufacturers

Is esketamine safe in pregnancy?

esketamine is not recommended during pregnancy. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to antidepressants, including esketamine, during pregnancy. Healthcare providers are encouraged to register patients by contacting the National Pregnancy Registry for Antidepressants at 1-844-405-6185 or online at women’s health

What is the brand name for esketamine?

SPRAVATO

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects

Drug Savings Tips

How can NowPatient help me to lower the cost of my esketamine prescription?

How do the NowPatient esketamine savings programs work?

Are the NowPatient esketamine savings programs suitable for everyone, regardless of insurance status?

	Rx Advantage Card* for esketamine	Canadian Prescription Savings* for esketamine	esketamine Drug Coupon*	esketamine Patient Assistance Program*
Insured (federal, state or government)	Available	Available	Not Available	Available If Offered by Pharmaceutical Company
Insured (Commercial or Private)	Available	Available	Available If Offered by Pharmaceutical Company	Available If Offered by Pharmaceutical Company
Uninsured	Available	Available	Not Available	Available If Offered by Pharmaceutical Company
Insured but without pharmacy benefit or drug coverage	Available	Available	Not Available	Available If Offered by Pharmaceutical Company

Are the NowPatient drug savings programs suitable for brand and generic versions of esketamine?

	Rx Advantage Card* for esketamine	Canadian Prescription Savings* for esketamine	esketamine Drug Coupon*	esketamine Patient Assistance Program*
Brand	Yes	Yes	Yes, If Offered by Pharmaceutical Company	Yes, If Offered by Pharmaceutical Company
Generic	Yes	Yes	No	No

If you have Medicare Part D or Medicare Advantage and none of the esketamine savings options are applicable or affordable for me, what can you do?

I am uninsured or underinsured and none of the esketamine prescription saving options are applicable or affordable for me, what can I do?

I am commercially or privately insured and none of the esketamine prescription saving options are applicable or affordable for me, what can I do?

If I have federal, state or commercial insurance and none of the esketamine prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay contributions?

If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:

1. Patient Access Network Foundation (PAN) assistance for esketamine

If you are having trouble paying for your esketamine medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for esketamine you will need to meet one or all of the following criteria:

Your income is below 400% of the federal poverty level
esketamine is prescribed for an approved FDA indication
You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
You have Medicare insurance coverage that covers esketamine
If esketamine is listed on PAN’s list of covered medications

You can check the Patient Access Network Foundation Website for more information.

2. HealthWell Foundation Copay Program for esketamine

If you are having trouble paying for your esketamine medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for esketamine you will need to meet the following criteria:

You live in and are being treated in the United States
You are insured and your plan covers esketamine
If esketamine is listed on the HealthWell Foundation’s list of covered medications

You can check the HealthWell Foundation Website for more information.

3. Patient Advocate Foundation Co-Pay Relief Program for esketamine

Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your esketamine treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for esketamine you will need to meet the following criteria:

You must be currently insured and have coverage for esketamine
You must have a confirmed diagnosis and treatment plan
You must reside and receive treatment in the United States
Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.

You can check the Patient Advocate Foundation Website for more information.

Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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