DoxepinPrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  1. Medication
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  2. Doxepin HCl
    Generic for Adapin
    30 capsules $5.4 USD
    Save $12.90
  3. Doxepin HCl
    Generic for Adapin
    120 capsules $10.5 USD
    Save $62.70
  4. Doxepin HCl
    Generic for Adapin
    60 capsules $6.3 USD
    Save $30.30
  5. Doxepin HCl
    Generic for Adapin
    60 capsules $7.5 USD
    Save $29.10
  6. Doxepin HCl
    Generic for Adapin
    90 capsules $9.6 USD
    Save $45.30
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Do you need a prescription for doxepin?

Yes, doxepin is only available with a valid physician Rx.

How much is doxepin without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase doxepin, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for doxepin in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a doxepin savings card?

Yes. Save up to 90% on your doxepin with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a doxepin coupon provider in the US?

No. Now Patient does not provide doxepin coupons or FREE doxepin samples.

Do you accept commercial, Medicare or Medicaid coverage for doxepin in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much doxepin?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using doxepin. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much doxepin. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic doxepin?

Generic doxepin refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of doxepin

Doxepin is approved by the U.S. Food and Drug Administration (FDA) for the treatment of various conditions, including depression and anxiety.

Active ingredient of doxepin

The active ingredient of doxepin is doxepin hydrochloride.

US brand name of doxepin and manufacturer

Doxepin is available under various brand names in the US, including Silenor and Sinequan. These medications are manufactured by different pharmaceutical companies.

UK brand name of doxepin and manufacturer

In the UK, doxepin is available under various brand names, and the manufacturers may vary.

Prescription requirement for doxepin

A prescription (Rx) is required for doxepin in both the US and the UK.

Availability of doxepin in the UK with NHS prescription

Doxepin is available in the UK with an NHS prescription.

Conditions treated by doxepin

Conditions for which doxepin is commonly prescribed include major depressive disorder, anxiety disorders, and insomnia. It is known as a tricyclic antidepressant (TCA) and works on the central nervous system (CNS) to increase levels of certain chemicals in the brain. The benefits of using doxepin for anxiety and depression lie in its ability to alleviate symptoms such as persistent sadness or worry, low energy levels, difficulty sleeping, and loss of interest in activities. Additionally, doxepin has shown potential therapeutic uses beyond mood disorders, including the treatment of chronic pain conditions like fibromyalgia and neuropathic pain.

How does doxepin work?

Doxepin belongs to a class of medications called tricyclic antidepressants. It works by altering the levels of certain chemicals in the brain, which helps to regulate mood and alleviate symptoms of anxiety and depression. Doxepin exerts its pharmacological mechanism through multiple actions on various neurotransmitter systems. By inhibiting the reuptake of serotonin and norepinephrine, doxepin increases their availability in the brain, improving mood and reducing feelings of anxiety or depression.

Doxepin also blocks certain receptors in the brain, such as histamine H1 receptors, alpha-adrenergic receptors, and muscarinic acetylcholine receptors. This blockade contributes to its sedative effects, making it useful for treating insomnia associated with mood disorders. Additionally, by affecting these receptor systems, doxepin may also help relieve neuropathic pain when used topically.

Forms of doxepin available

Doxepin is available in various forms, including oral capsules and oral solutions.

Dosage of doxepin

The dosage of doxepin may vary depending on the specific condition being treated, the severity of the symptoms, and individual patient factors. It is important to follow the prescribed dosage instructions provided by the healthcare provider.

Directions for doxepin use

Doxepin should be taken exactly as directed by the healthcare provider. The capsules should be swallowed whole with a glass of water. The oral solution should be measured using the provided dropper or oral syringe.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Warnings and precautions for doxepin

  • Doxepin may increase the risk of suicidal thoughts and behaviors, particularly in children, adolescents, and young adults
  • It may cause drowsiness and impair cognitive and motor functions, so caution should be exercised when operating machinery or driving
  • Inform your healthcare provider about any allergies or previous adverse reactions to tricyclic antidepressants (TCA)
  • Discuss the use of doxepin if you have a history of heart problems, liver or kidney disease, seizures, urinary retention, or glaucoma
  • Avoid alcohol consumption while taking doxepin
  • Individuals who are currently using monoamine oxidase inhibitors (MAOIs) or have used them within the past 14 days should take doxepin with caution
  • Doxepin should not be used in patients with untreated narrow-angle glaucoma
  • Doxepin should not be used in people experiencing an acute episode of myocardial infarction (heart attack)
  • Use caution when prescribing in patients with bipolar disorder due to the potential risk for switch to manic episodes
  • Exercise caution in patients with a history of suicidal thoughts or behavior. Close monitoring is essential during the initial phase of treatment

Drug interactions for doxepin

When taking doxepin, it is crucial to be aware of any potential drug interactions that could occur. Certain medications can have adverse effects when combined with doxepin, leading to increased side effects or reducing the effectiveness of either drug. Here are some medications that should not be taken with doxepin:

  • Combining doxepin with MAO inhibitors can result in a dangerous condition known as serotonin syndrome. Symptoms of serotonin syndrome include confusion, rapid heartbeat, fever, tremors, and muscle stiffness. Examples of MAOIs include phenelzine, tranylcypromine, and isocarboxazid
  • Taking doxepin with selective serotonin reuptake inhibitors (SSRIs) can increase the risk of serotonin syndrome. SSRIs include medications like fluoxetine, sertraline, and citalopram. It is essential to consult with your healthcare provider before combining these medications
  • Certain antiarrhythmic medications, such as quinidine or flecainide, can increase the risk of heart rhythm disturbances when taken with doxepin. This combination should be avoided or closely monitored under medical supervision
  • Taking anticoagulant medications, like warfarin or heparin, with doxepin may increase the risk of bleeding
  • It is important to note that this list is not exhaustive, and there may be other medications that can interact with doxepin. Always consult with your healthcare provider or pharmacist before starting any new medications or combining medications

Additionally, it is crucial to inform a healthcare professional about all the medications you are currently taking, including over-the-counter drugs, herbal supplements, and vitamins. They can provide guidance on potential interactions and help you make informed decisions about your medication regimen.

Use of doxepin during pregnancy

Doxepin should be used during pregnancy only if the potential benefits outweigh the potential risks. Consultation with a healthcare provider is necessary to discuss the specific situation.

Use of doxepin while breastfeeding

Doxepin may pass into breast milk and may have adverse effects on the nursing infant. It is generally not recommended while breastfeeding. Consultation with a healthcare provider is necessary to discuss alternative treatment options.

Possible side effects of doxepin

Common side effects of doxepin may include drowsiness, dry mouth, blurred vision, constipation, and weight changes. Serious side effects are rare but can include allergic reactions, cardiovascular effects, and changes in blood pressure.

Similar drugs to doxepin

Other tricyclic antidepressants similar to doxepin include amitriptyline, imipramine, and nortriptyline.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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