DofetilidePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Dofetilide
    Generic for Tikosyn
    30 capsules $6.9 USD
    Save $244.80
  3. Dofetilide
    Generic for Tikosyn
    45 capsules $8.7 USD
    Save $368.85
  4. Dofetilide
    Generic for Tikosyn
    30 capsules $6.9 USD
    Save $244.80
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Do you need a prescription for dofetilide?

Yes, dofetilide is only available with a valid physician Rx.

How much is dofetilide without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase dofetilide, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for dofetilide in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a dofetilide savings card?

Yes. Save up to 90% on your dofetilide with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a dofetilide coupon provider in the US?

No. Now Patient does not provide dofetilide coupons or FREE dofetilide samples.

Do you accept commercial, Medicare or Medicaid coverage for dofetilide in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much dofetilide?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using dofetilide. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much dofetilide. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic dofetilide?

Generic dofetilide refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of dofetilide

Dofetilide is approved by the U.S. Food and Drug Administration (FDA) for the treatment of certain irregular heart rhythms, such as atrial fibrillation or atrial flutter.

Active ingredient of dofetilide

The active ingredient of dofetilide is dofetilide.

US brand name of dofetilide and manufacturer

Dofetilide is available in the US under the brand name Tikosyn. It is manufactured by Pfizer Inc.

UK brand name of dofetilide and manufacturer

In the UK, dofetilide is not marketed.

Prescription requirement for dofetilide

A prescription (Rx) is required for dofetilide in the US.

Availability of dofetilide in the UK with NHS prescription

Dofetilide is not available in the UK.

Conditions treated by dofetilide

Dofetilide is primarily used for the treatment of certain irregular heart rhythms, particularly atrial fibrillation or atrial flutter.

How does dofetilide work?

Dofetilide belongs to a class of medications known as antiarrhythmic drugs specifically a class III antiarrhythmic agent. It works by blocking certain electrical channels in the heart, which helps to restore and maintain a normal heart rhythm.
The main way dofetilide works is by blocking certain potassium channels in the heart. These channels, known as rapid delayed rectifier potassium channels, play a crucial role in the repolarization of cardiac cells. By blocking these channels, dofetilide prolongs the action potential duration and refractory period of the heart.
By prolonging the action potential duration, dofetilide helps to restore a regular rhythm in the heart. It does this by preventing certain abnormal electrical signals or impulses from rapidly firing and causing chaotic rhythms. This allows the heart to beat in a more coordinated and regular manner.

Forms of dofetilide available

Dofetilide is available in the form of oral capsules.

Dosage of dofetilide

The dosage of dofetilide may vary depending on the individual’s condition, medical history, and response to the medication. It is important to follow the recommended dosage instructions provided by the healthcare provider.

Directions for dofetilide use

Dofetilide should be taken exactly as directed by the healthcare provider. The medication is usually taken orally, with or without food. It is important to take dofetilide consistently and continue the prescribed treatment course.

Warnings and precautions for dofetilide

  • Dofetilide may cause certain side effects, including changes in heart rhythm, dizziness, and chest pain. It may also increase the risk of life-threatening ventricular arrhythmias. Close monitoring is necessary during treatment
  • One of the major concerns with dofetilide is the risk of a type of abnormal heart rhythm called torsades de pointes. Certain medications can increase this risk when taken together with dofetilide
  • If you have impaired renal function or your creatinine clearance falls below a certain threshold, taking dofetilide may be contraindicated. Additionally, if you have hypokalemia (low potassium levels), low magnesium levels or long QT syndrome, it is important to consult with your healthcare provider before starting dofetilide treatment. These pre-existing conditions can affect the safety and effectiveness of this medication in managing heart rhythm disorders
  • It is important to inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements. They can evaluate the potential adverse effects and make necessary adjustments to your treatment plan to ensure the safety and effectiveness of the medications

Drug interactions with dofetilide

 Some examples of medications that can interact with dofetilide include:

  • Taking dofetilide with other cardiovascular or antiarrhythmic drugs such as digoxin, and verapamil can increase the risk of developing abnormal heart rhythms
  • Cimetidine and trimethoprim-sulfamethoxazole can increase the levels of dofetilide in the blood, potentially leading to an increased risk of side effects
  • Diuretic medications such as furosemide and hydrochlorothiazide can lower potassium levels in the body. Low potassium levels can increase the risk of developing abnormal heart rhythms when combined with dofetilide
  • Macrolide antibiotics, such as erythromycin and clarithromycin, can interact with dofetilide and increase the risk of abnormal heart rhythms
  • Antifungal medications, such as ketoconazole and itraconazole, can interact with dofetilide and increase the risk of abnormal heart rhythms
  • Certain selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants can interact with dofetilide and increase the risk of abnormal heart rhythms

Use of dofetilide during pregnancy

The use of dofetilide during pregnancy should be carefully considered, and the potential risks and benefits should be discussed with a healthcare provider. The medication is generally not recommended during pregnancy unless the potential benefits outweigh the risks.

Use of dofetilide while breastfeeding

It is not known whether dofetilide passes into breast milk. The use of dofetilide while breastfeeding should be discussed with a healthcare provider, considering the potential risks and benefits for the mother and the infant.

Possible side effects of dofetilide

In clinical trials common side effects of dofetilide may include dizziness, headache, and abnormal taste sensations.
Serious side effects are possible but less common:

  • Dofetilide can cause a lengthening of the QT interval, which is a measurement of the electrical activity in the heart. QTC (QT prolongation) can increase the risk of a dangerous heart rhythm called torsades de pointes, which can lead to fainting or even sudden cardiac arrest
  • In some cases, dofetilide can trigger ventricular tachycardia, a rapid and potentially life-threatening heart rhythm originating from the lower chambers of the heart. This condition requires immediate medical attention

Similar drugs to dofetilide

Other antiarrhythmic medications used for the treatment of irregular heart rhythms include amiodarone, sotalol, and flecainide.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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