Dimethyl Fumarate

Dimethyl FumaratePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Dimethyl Fumarate
    Generic for Tecfidera
    14 Capsules delayed release capsules $15.08 USD
    Save $2160.98
  3. Dimethyl Fumarate
    Generic for Tecfidera
    60 Capsules (14 Caps 120mg & 46 Caps 240mg) capsules $54.75 USD
    Save $8649.49
  4. Dimethyl Fumarate
    Generic for Tecfidera
    60 Capsules delayed release capsules $37.5 USD
    Save $6490.68
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Do you need a prescription for dimethyl fumarate?

Yes, dimethyl fumarate is only available with a valid physician Rx.

How much is dimethyl fumarate without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase dimethyl fumarate, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for dimethyl fumarate in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a dimethyl fumarate savings card?

Yes. Save up to 90% on your dimethyl fumarate with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a dimethyl fumarate coupon provider in the US?

No. Now Patient does not provide dimethyl fumarate coupons or FREE dimethyl fumarate samples.

Do you accept commercial, Medicare or Medicaid coverage for dimethyl fumarate in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much dimethyl fumarate?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using dimethyl fumarate. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much dimethyl fumarate. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic dimethyl fumarate?

Generic dimethyl fumarate refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of dimethyl fumarate

Dimethyl fumarate is approved by the U.S. Food and Drug Administration (FDA) for the treatment of multiple sclerosis (MS).

Active ingredient of dimethyl fumarate

The active ingredient of dimethyl fumarate is dimethyl fumarate (DMF).

US brand name of dimethyl fumarate and manufacturer

Dimethyl fumarate is available in the US under the brand name Tecfidera. It is manufactured by Biogen.

UK brand name of dimethyl fumarate and manufacturer

In the UK, dimethyl fumarate is available under various brand names, including Tecfidera. The manufacturer may vary depending on the brand name.

Prescription requirement for dimethyl fumarate

A prescription (Rx) is required for dimethyl fumarate in both the US and the UK.

Availability of dimethyl fumarate in the UK with NHS prescription

Dimethyl fumarate is available in the UK with an NHS prescription.

Conditions treated by dimethyl fumarate

Dimethyl fumarate is primarily used for the treatment of relapsing forms of multiple sclerosis (MS), including relapsing-remitting MS (relapsing-remitting multiple sclerosis or RRMS) and active secondary progressive MS.

How does dimethyl fumarate work?

One of the key components of dimethyl fumarate’s mechanism of action is its ability to activate a specific pathway called the Nrf2 pathway. Nrf2 is a protein that helps regulate the body’s antioxidant response and promotes the production of various protective enzymes. By activating this pathway, dimethyl fumarate helps to increase the antioxidant capacity of cells, which can help reduce oxidative stress and inflammation.
In addition to its effects on the Nrf2 pathway, dimethyl fumarate also has immunomodulatory properties. It is believed to work by suppressing the activity of certain immune cells, such as T cells and dendritic cells, which play a role in the inflammatory response. By reducing the activity of these cells, dimethyl fumarate can help decrease the production of pro-inflammatory molecules, thus reducing inflammation in the body.
Another mechanism by which dimethyl fumarate may work is by affecting the balance of immune cells in the central nervous system (CNS). In MS, the immune system mistakenly attacks the protective covering of nerve fibers in the CNS, leading to inflammation and damage. Dimethyl fumarate is thought to shift the balance of immune cells in the CNS, favoring the presence of regulatory T cells, which help suppress the immune response and reduce inflammation. This shift in the balance of immune cells is believed to contribute to the therapeutic effects of dimethyl fumarate in treating MS.

Forms of dimethyl fumarate available

Dimethyl fumarate is available in the form of a capsule, delayed release.

Dosage of dimethyl fumarate

The dosage of dimethyl fumarate may vary depending on the individual’s condition, medical history, and response to the medication. It is essential to follow the recommended dosage instructions and patient information provided by the healthcare provider.

Directions for dimethyl fumarate use

Dimethyl fumarate should be taken exactly as directed by the healthcare provider. The medication is usually taken orally, with or without food. It is important to swallow the capsules whole and avoid crushing or chewing them.
Store this medicine in the original container at room temperature, away from moisture, heat, and light.

Warnings and precautions for dimethyl fumarate

  • Dimethyl fumarate may cause certain side effects, including flushing, gastrointestinal symptoms, and a decrease in white blood cell counts. Regular blood tests and monitoring are necessary during treatment
  • Dimethyl fumarate can decrease the number of lymphocytes (a type of white blood cell) in the body. If you have a history of low lymphocyte counts (lymphopenia) or any condition that affects your immune system, such as HIV/AIDS, you should inform your doctor before starting DMF
  • Dimethyl fumarate can increase your chances of getting a rare viral brain infection called PML (progressive multifocal leukoencephalopathy)
  • If you have a weakened immune system due to conditions such as organ transplantation, cancer, or autoimmune diseases, DMF may not be suitable for you. It is important to discuss your medical history with a healthcare professional to determine if DMF is safe and appropriate
  • Inform the healthcare provider about all medications being taken, as dimethyl fumarate may interact with certain medications and cause adverse effects

Use of dimethyl fumarate during pregnancy and breastfeeding

The use of dimethyl fumarate during pregnancy and breastfeeding should be carefully considered, and the potential risks and benefits should be discussed with a healthcare provider. It is important to balance the potential benefits of treatment with the potential risks to the fetus or the infant.

Possible side effects of dimethyl fumarate

In clinical trials common side effects of dimethyl fumarate may include flushing, stomach upset, abdominal pain, loss of appetite, diarrhea, and headache. Serious side effects are rare but may include allergic reactions or liver problems. Promptly report any concerning symptoms to a healthcare provider.

Similar drugs to dimethyl fumarate

Other medications used for the treatment of multiple sclerosis include interferon beta, glatiramer acetate, and natalizumab.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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