DEPO-ESTRADIOL

DEPO-Estradiol is prescribed for the management of moderate to severe menopausal symptoms that occur during and after menopause. Estrogens, which are naturally produced by the ovaries, decrease in production as women reach the age of 45 to 55.

During menopause, women experience a decrease in estradiol, a specific estrogen hormone, which plays a role in regulating metabolism and body weight. This decline in estradiol levels can lead to weight gain. Additionally, women may observe weight gain specifically around their hips and thighs throughout their lifetime.

If you are experiencing vaginal dryness or irritation in addition to hot flashes caused by menopause, Depo-Estradiol (estradiol cypionate injection) may not be the most suitable treatment for you. It is recommended that you discuss alternative options with your healthcare provider.

When pills are taken orally, the stomach may destroy some of them. However, injections are easier for the body to absorb and utilize, ensuring that none of the beneficial components are lost during the process. Additionally, injections can provide a more consistent and steady supply rate.

Depo-Provera, also known as medroxyprogesterone acetate, is a popular contraceptive injection containing the hormone progestin. It is administered every three months and works by suppressing ovulation, preventing the release of eggs from the ovaries.

In addition to treating menopausal symptoms, Estradiol topical gel can also be used to alleviate vaginal dryness, itching, and burning. However, women who solely experience these symptoms may find more relief from a medication specifically applied to the vagina.

You may experience nausea/vomiting, bloating, breast tenderness, headache, or weight changes while taking this medication. If any of these symptoms persist or worsen, please inform your doctor or pharmacist immediately. It is important to remember that your doctor has prescribed this medication because they believe that the benefits outweigh the potential risks of side effects.

Caution: Prolonged use of this medication may heighten the likelihood of developing breast cancer, endometrial cancer, or uterine cancer. It is advisable to discuss this risk with your doctor. If you still have your uterus, consult your doctor about the potential need for a progestin medication as well.

You may notice that your skin becomes drier and thinner, with smaller pores and reduced oil production. You may also become more prone to bruising and cuts, and notice changes in the odors of your sweat and urine in the first few weeks.

Since early 2022, Pfizer, the sole supplier of synthetic estrogen (estradiol valerate) injections in the United States, has been experiencing chronic shortages of their product, Depo-Estradiol, due to manufacturing delays.

Using Depo-Provera for an extended period of time (over 2 years) can lead to increased calcium loss, which in turn raises the risk of weakened bones. It is important to note that calcium levels may not fully recover even after discontinuing Depo-Provera.

Low levels of estrogen can lead to abnormalities in sexual development and sexual function, as well as an increased likelihood of obesity, osteoporosis, and cardiovascular diseases. Fortunately, treatments for these conditions have advanced and become more successful over time.

Bayer, the manufacturer of Climara, informed ABC that the discontinuation of the product was due to a worldwide “strategic decision.” They also mentioned that they have other hormone replacement therapy (HRT) products available in the market.

Depo Provera maintains low and stable hormone levels throughout your menstrual cycle, preventing the thickening of the uterine lining. As a result, during your period, there is minimal lining to shed, leading to reduced bleeding compared to the usual amount.

Generic form of Depo-Estradiol is available.

Estradiol: There is a lower-cost generic available for Estradiol.

Premarin (conjugated estrogens): There is no lower-cost generic available for Premarin.

Activella (estradiol / norethindrone): There is a lower-cost generic available for Activella.

Ratings & Reviews: No information provided.

Estradiol, also known as 17ß-estradiol, is the bioidentical version of estrogen and is considered the most effective and safest form of hormone therapy for gender affirmation.

Depo-Estradiol (estradiol cypionate injection) typically remains effective for approximately one month. However, individuals experiencing severe hot flashes or night sweats may require a dosage every three weeks.

Please insert the sterile needle into the hip (ventrogluteal muscle), upper arm (deltoid muscle), buttocks (gluteal muscle, upper outer portion), or outer (anterior) thigh, as preferred by the woman. Inject the contents of the syringe and do not massage the injection site.

Phytoestrogens are substances that mimic the hormone estrogen. When consumed in high doses, phytoestrogens can stimulate the growth of breast tissue, potentially leading to an increase in breast size. However, it is important to note that using estrogen in this manner is not considered safe. This is because when breast cells are stimulated to grow, there is an increased risk of them becoming cancerous.

DEPO-Estradiol Injection is a medication that is administered intramuscularly and contains estradiol cypionate. Each milliliter of the injection contains 5 milligrams of estradiol cypionate, 5.4 milligrams of chlorobutanol anhydrous (a chloral derivative) as a preservative, and 913 milligrams of cottonseed oil.

DEPO®-ESTRADIOL is a medication manufactured by Pfizer.

Generally, it is believed that transdermal or injected estrogen treatment is safer than oral treatment due to the absence of hepatic first pass effect. Additionally, topical and injectable estrogens require less frequent administration, which may contribute to easier management.

As of June 2023, there has been a significant increase in the overall supply of HRT products compared to the previous year. In 2022, there was a shortage of 22 HRT products, leading to the implementation of the ‘serious shortage protocol’ (SSP). As a result, substitutes such as estradiol patches and estriol cream were introduced. However, as of June 2023, only 2 HRT products are still subject to the SSP, indicating a substantial improvement in the availability of HRT supplies.

Conventional hormone replacement therapy (HRT) is used to alleviate menopause symptoms by replicating the hormones produced by the ovaries. It typically consists of both estrogen and progesterone components. There are various estrogen therapies available, including those naturally produced by the ovaries such as estradiol and estriol.

DEPO-Estradiol Injection is a medication that is administered intramuscularly and contains estradiol cypionate. Each milliliter of the injection contains 5 milligrams of estradiol cypionate, 5.4 milligrams of chlorobutanol anhydrous (a chloral derivative) as a preservative, and 913 milligrams of cottonseed oil.

The injection, known as Depo-Provera, includes medroxyprogesterone acetate, a synthetic progesterone called progestin. It does not contain estrogen. Its mechanism of action involves preventing ovulation, which is the release of eggs from the ovary, thus preventing pregnancy.

According to the University of California, San Francisco Gender-Affirming Health Program, there is a shortage of injectable estrogen because manufacturers have little motivation to produce this medicine, as it is rarely used outside of trans health care.

Generic Name Revision Date
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Dopamine Hydrochloride Injection January 2, 2024

As of June 2023, there has been a significant increase in the overall supply of HRT products compared to the previous year. In 2022, there was a shortage of 22 HRT products, leading to the implementation of the ‘serious shortage protocol’ (SSP). As a result, substitutes such as estradiol patches and estriol cream were introduced. However, as of June 2023, only 2 HRT products are still subject to the SSP, indicating a substantial improvement in the availability of HRT supplies.

Depo-Estradiol (estradiol cypionate injection) is specifically approved by the FDA for the treatment of hot flashes resulting from menopause. However, if you are experiencing vaginal dryness or irritation in addition to hot flashes, this medication may not be the most suitable choice for you.

There is currently a shortage of both generic and brand name injectable estrogen nationwide. The companies responsible for manufacturing the medication are facing difficulties in production, resulting in delays in getting the drugs to the market.