DEPO-ESTRADIOL
Used for Menopause
Are you tired of high medication costs? Our service offers unbeatable savings on your DEPO-ESTRADIOL prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.
Manufactured by Pfizer
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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DEPO-ESTRADIOL key facts
What is DEPO-ESTRADIOL?
DEPO-ESTRADIOL is the brand name for estradiol cypionate and is available as an intramuscular injection.
What dosages is DEPO-ESTRADIOL available in?
DEPO-ESTRADIOL is available as an intramuscular injection.
What is DEPO-ESTRADIOL used for?
DEPO-ESTRADIOL is an estrogen replacement and is used for the following:
- Hot flashes, night sweats, and flushing caused by menopause
- Low estrogen conditions
How does DEPO-ESTRADIOL work?
DEPO-ESTRADIOL replaces estrogen hormones that your body loses during menopause. Replacing estrogen relieves the hot flashes and night sweats caused by menopause.
How do I take DEPO-ESTRADIOL?
DEPO-ESTRADIOL is dosed as follows:
Hot flashes: Inject 1 mg to 5 mg into a muscle every 3 to 4 weeks. Work with your provider to taper off this medication as soon as you can.
- Low estrogen conditions: Inject 1.5 mg to 2 mg into a muscle once a month
Is it safe for me to take DEPO-ESTRADIOL?
DEPO-ESTRADIOL is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. Estrogens should not be used in individuals with any of the following conditions:
- Undiagnosed abnormal genital bleeding
- Known or suspected cancer of the breast
- Known or suspected estrogen-dependent neoplasia
- Active deep vein thrombosis, pulmonary embolism or history of these conditions
- Active or recent (e.g., within the past year) arterial thromboembolic disease (e.g., stroke, myocardial infarction)
- Liver dysfunction or disease
- DEPO-Estradiol should not be used in patients with known hypersensitivity to itsm ingredients. Known or suspected pregnancy. There is no indication for DEPO-Estradiol in pregnancy
- There appears to be little or no increased risk of birth defects in children born to women who have used estrogens and progestins from oral contraceptives
inadvertently during early pregnancy
DEPO-ESTRADIOL Common Side Effects
Common side effects of DEPO-ESTRADIOL:
- Pain/tenderness where the medication is injected
- Breast tenderness or growth
- Nausea
- Headaches/migraines
- Vomiting
- Stomach cramps
- Vaginal spotting/breakthrough bleeding
- Weight gain
DEPO-ESTRADIOL Serious Side Effects
Serious side effects are rare with DEPO-ESTRADIOL. Contact your healthcare provider immediately if you experience any of the following.
- Heart attack: chest pain or tightness, pain that radiates up to your shoulder, arm, neck, or jaw
- Stroke: sudden trouble talking, trouble walking, or numbness on one side of your body or face
- Allergic reactions: trouble breathing, hives, swelling of your face, lips, tongue, or throat
- Shortness of breath
- Sudden, severe headaches
- Breasts lumps or pain
- Unusual or heavy vaginal bleeding
Effects of other drugs, drug classes and over-the-counter products on DEPO-ESTRADIOL
The following medications may interact with DEPO-ESTRADIOL:
- Inducers or inhibitors of CYP3A4 may
- affect estrogen drug metabolism. Inducers of CYP3A4 such as St. John’s Wort preparations (Hypericum perforatum), phenobarbital, carbamazepine, and rifampin may reduce plasma concentrations of estrogens, possibly resulting in a decrease in therapeutic
- effects and/or changes in the uterine bleeding profile. Inhibitors of CYP3A4 such as erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir and grapefruit juice may increase plasma concentrations of estrogens and may result in side effects
Who makes DEPO-ESTRADIOL?
Pfizer
Is DEPO-ESTRADIOL safe in pregnancy?
DEPO-ESTRADIOL should not be used during pregnancy.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my DEPO-ESTRADIOL prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your DEPO-ESTRADIOL prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient DEPO-ESTRADIOL savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient DEPO-ESTRADIOL savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for DEPO-ESTRADIOL | Canadian Prescription Savings* for DEPO-ESTRADIOL | DEPO-ESTRADIOL Drug Coupon* | DEPO-ESTRADIOL Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of DEPO-ESTRADIOL?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for DEPO-ESTRADIOL | Canadian Prescription Savings* for DEPO-ESTRADIOL | DEPO-ESTRADIOL Drug Coupon* | DEPO-ESTRADIOL Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the DEPO-ESTRADIOL savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the DEPO-ESTRADIOL drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for DEPO-ESTRADIOL, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the DEPO-ESTRADIOL prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, DEPO-ESTRADIOL is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed DEPO-ESTRADIOL for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the DEPO-ESTRADIOL prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the DEPO-ESTRADIOL prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for DEPO-ESTRADIOL
If you are having trouble paying for your DEPO-ESTRADIOL medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for DEPO-ESTRADIOL you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- DEPO-ESTRADIOL is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers DEPO-ESTRADIOL
- If DEPO-ESTRADIOL is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for DEPO-ESTRADIOL
If you are having trouble paying for your DEPO-ESTRADIOL medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for DEPO-ESTRADIOL you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers DEPO-ESTRADIOL
- If DEPO-ESTRADIOL is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for DEPO-ESTRADIOL
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your DEPO-ESTRADIOL treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for DEPO-ESTRADIOL you will need to meet the following criteria:
- You must be currently insured and have coverage for DEPO-ESTRADIOL
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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