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Dapagliflozin is available as a 5 mg and 10 mg oral tablet.

Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that is used for:

• Type 2 diabetes
• Lowering the risk of hospitalization for heart failure in adults with Type 2 diabetes and heart disease
• Lowering the risk of hospitalization and death due to heart problems in people with heart failure
• Lowering the risk of worsening kidney problems, hospitalization for heart failure, and death due to heart problems in adults with CKD

Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It works in the kidneys to prevent the absorption of sugar and sodium (salt) back into your body.

• For Type 2 diabetes: It lowers blood sugar by causing your body to get rid of excess sugar through your urine
• For heart failure and CKD: By preventing sodium reabsorption, the heart fills with blood easier and pumps blood more easily throughout the body. This might also improve blood flow through the kidneys and lower the stress on these organs to help slow the worsening of CKD

Dapagliflozin is typically dosed as follows:

• For people with Type 2 diabetes: The typical starting dose is 5 mg by mouth once daily. Your provider might raise your dose depending on your response to the medication
• For people with heart failure or CKD: The typical starting dose is 10 mg by mouth once daily

Dapagliflozin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• History of serious hypersensitivity reaction to Dapagliflozin.
  Severe renal impairment (eGFR less than 30 mL/min/1.73 m2) in patients who are being treated for glycemic control without established cardiovascular disease or cardiovascular risk factors
• Patients on dialysis

Common side effects of Dapagliflozin:

• Vaginal yeast infection in females
• Nose and throat infection
• Urinary tract infection
• Back pain
• Pain in hands or feet
• More frequent urination

Serious side effects are rare with Dapagliflozin. Contact your healthcare provider immediately if you experience any of the following.

• High ketone levels in the blood: nausea, vomiting, stomach pain, tiredness, thirsty, dry mouth, fruity breath, trouble breathing

There are no major drug interactions listed for Dapagliflozin. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Various FDA-approved generic manufacturers

Dapagliflozin may harm your unborn baby. If you become pregnant while taking Dapagliflozin, your healthcare provider may switch you to a different medicine to control your blood sugar. Talk to your
healthcare provider about the best way to control your blood sugar if you plan to become pregnant or while you are
pregnant.

• Farxiga