dabrafenib
Used for Cancer
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Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
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dabrafenib Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is dabrafenib available in?
dabrafenib is available as a 50 mg and 75 mg oral capsule and a 10 mg tablet for suspension.
What is dabrafenib used for?
dabrafenib is a kinase inhibitor that is used to treat:
- Melanoma with certain BRAF mutations
- Advanced melanoma, given after surgery and used with
- Mekinist (trametinib)
- Melanoma that has spread (metastatic) or can’t be removed by surgery, used alone or with Mekinist (trametinib)
- Metastatic non-small cell lung cancer (NSCLC) with a certain BRAF mutation, used with Mekinist (trametinib)
- Metastatic anaplastic thyroid cancer (ATC) with a certain BRAF mutation, used with Mekinist (trametinib)
- Solid tumors with a certain BRAF mutation that have spread (metastatic) or can’t be removed by surgery, used with Mekinist (trametinib)
- Low-grade glioma (LGG) with a certain BRAF mutation, used with Mekinist (trametinib)
How does dabrafenib work?
dabrafenib s a kinase inhibitor known as a BRAF inhibitor. The BRAF protein is part of a whole chain of proteins that help cells grow. When the BRAF protein is mutated, the cancer grows uncontrollably and can spread more quickly. By blocking BRAF, it helps stop tumor growth.
How do I take dabrafenib?
dabrafenib is dosed as follows:
- Adults: The typical dose is 150 mg by mouth twice a day (about 12 hours apart)
- Children: The dose is based on your child’s body weight. The typical dose ranges from 20 mg to 150 mg by mouth twice a day (about 12 hours apart)
Is it safe for me to take dabrafenib?
dabrafenib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
dabrafenib Common Side Effects
Common side effects of dabrafenib:
- High blood sugar
- Higher liver enzymes in the blood
- Fever
- Tiredness
- Changes in other blood test results
- Rash
- Nausea
- Headache
- Chills
- Diarrhea
- Vomiting
- Cough
- Muscle or joint pain
- Constipation
dabrafenib Serious Side Effects
Serious side effects are rare with dabrafenib. Contact your healthcare provider immediately if you experience any of the following.
- Bleeding: nosebleed, blood in stool, sudden and severe headache
- Serious eye problems: sudden and severe eye pain, sudden vision loss
- Serious skin reactions: painful blisters, skin wounds, peeling skin, fever, muscle aches
- Serious blood problems: fever, severe tiredness, weakness, trouble breathing
Effects of other drugs, drug classes and over-the-counter products on dabrafenib
The following medications may interact with dabrafenib:
- Avoid concurrent administration of strong inhibitors of CYP3A4 or CYP2C8
- Concomitant use with agents that are sensitive substrates of CYP3A4
- CYP2C8, CYP2C9, CYP2C19, or CYP2B6 may result in loss of efficacy of these agents
Who makes dabrafenib?
Various FDA-approved generic manufacturers
Is dabrafenib safe in pregnancy?
dabrafenib can harm your unborn baby.
Females who are able to become pregnant:
- Your healthcare provider will do a test to see if you are pregnant before starting treatment with dabrafenib
- You should use effective birth control (contraception) during treatment with dabrafenib and for 2 weeks after
your last dose of dabrafenib - Birth control methods that contain hormones (such as birth control pills, injections, or transdermal systems) may not work as well during treatment with dabrafenib and you could become pregnant. You should use another
effective method of birth control during treatment with dabrafenib - Talk to your healthcare provider about birth control methods that may be right for you during this time.
Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with dabrafenib - Males (including those who have had a vasectomy) with a female partner who is able to become pregnant:
- Use condoms during sexual intercourse during treatment with dabrafenib and for at least 2 weeks after your last dose of dabrafenib
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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