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crizotinib

crizotinib

Used for Cancer

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Manufactured by various FDA-approved generic manufacturers.

*Applicable to Drug Coupons & Patient Assistance Programs

This content is intended for US audiences only

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Navin Khosla NowPatientGreen tick
Updated on 24 Apr 2024

Learn more about crizotinib

What dosages is crizotinib available in?

What dosages is crizotinib available in?

crizotinib is available as 200 mg and 250 mg oral capsules and 20 mg, 50 mg, and 150 mg oral pellets.

What is crizotinib used for?

What is crizotinib used for?

crizotinib is a tyrosine kinase inhibitor that is used to treat:

  • Metastatic non-small-cell lung cancer (NSCLC) with an ALK or ROS1 mutation
  • Advanced anaplastic large cell lymphoma (ALCL) with an ALK mutation
  • Advanced inflammatory myofibroblastic tumor (IMT) with an ALK mutation
How does crizotinib work?

How does crizotinib work?

crizotinib works by targeting cells that have genetic changes (mutations) in specific receptors, such as anaplastic lymphoma kinase (ALK) and ROS1. These genetic changes cause cells to become cancer cells. When crizotinib blocks the activity of these receptors, cancer cells can’t grow and spread as well.

How do I take crizotinib?

How do I take crizotinib?

crizotinib is dosed as follows:

NSCLC

  • Adults: The usual dose is 250 mg by mouth twice a day

ALCL

  • Children and young adults: Your provider will determine your dose based on body surface area (BSA), which is a measurement of body size that takes into account weight and height. The usual dose ranges from 200 mg to 500 mg twice a day, depending on body size

IMT

  • Adults: The usual dose is 250 mg by mouth twice a day
  • Children: Your child’s provider will determine your child’s dose based on their body size, taking into account their weight and height. The usual dose ranges from 200 mg to 500 mg twice a day, depending on body size
Is it safe for me to take crizotinib?

Is it safe for me to take crizotinib?

crizotinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

crizotinib Common Side Effects

crizotinib Common Side Effects

Common side effects of crizotinib:

  • Vomiting
  • Diarrhea
  • Nausea
  • Higher liver labs, suggesting liver irritation
  • Vision changes
  • Runny nose, sore throat, and other symptoms of an upper respiratory infection
  • Headache
  • Muscle pain
  • Fever
  • Swelling in the legs and feet
  • Lower blood cell counts
  • Mouth sores
crizotinib Serious Side Effects

crizotinib Serious Side Effects

Serious side effects are rare with crizotinib. Contact your healthcare provider immediately if you experience any of the following.

  • Serious lung problems: sudden cough, fever, and difficulty breathing
  • Heart rhythm problems: lightheadedness, blurry vision, fainting, seizures, loss of consciousness
  • Serious liver problems: nausea, vomiting, tiredness, stomach pain or swelling, pale-colored stool, dark-colored urine, yellowing of the whites of the eyes or skin
Effects of other drugs, drug classes and over-the-counter products on crizotinib

Effects of other drugs, drug classes and over-the-counter products on crizotinib

The following medications may interact with crizotinib:

  • Strong CYP3A Inhibitors: Avoid concomitant use
  • Strong CYP3A Inducers: Avoid concomitant use
  • CYP3A Substrates: Avoid concomitant use with CYP3A substrates, where minimal concentration changes may lead to serious adverse reactions
Who makes crizotinib?

Who makes crizotinib?

Various FDA-approved generic manufacturers

Is crizotinib safe in pregnancy?

Is crizotinib safe in pregnancy?

crizotinib can harm your unborn baby.

Females who are able to become pregnant:

  • Your healthcare provider will check to see if you are pregnant before starting treatment with crizotinib.
    Effective birth control (contraception) should be used during treatment with crizotinib and for 45 days after the last dose of crizotinib
  • Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with crizotinib

Males who have female partners who can become pregnant:

  • You should use condoms during treatment with crizotinib and for 90 days after the last dose of crizotinib
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What to do if you missed your crizotinib dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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