CRESEMBA
Used for Fungal Infections
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Manufactured by Astellas Pharma
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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CRESEMBA key facts
What is CRESEMBA?
CRESEMBA is the brand name for isavuconazonium sulfate and is available as an oral capsule and an injection.
What dosages is CRESEMBA available in?
CRESEMBA for injection is supplied in a single-dose vial as a
sterile lyophilized powder containing 372 mg of isavuconazonium sulfate (equivalent to 200 mg of isavuconazole). CRESEMBA capsules: contains 74.5 mg of isavuconazonium sulfate (equivalent to 40 mg of isavuconazole), and 186 mg of isavuconazonium sulfate (equivalent to 100 mg of isavuconazole).
What is CRESEMBA used for?
CRESEMBA is an antifungal that is used to treat:
- Invasive aspergillosis (a serious fungal infection affecting multiple areas of the body)
- Invasive mucormycosis (a serious fungal infection affecting multiple areas of the body)
How does CRESEMBA work?
CRESEMBA is an antifungal. It kills the fungus causing your infection by damaging its protective outer layer.
How do I take CRESEMBA?
CRESEMBA is dosed as follows:
- Dosing for IV infusion: Infuse 1 vial (372 mg) of CRESEMBA through an IV line every 8 hours for 6 doses (this is the first 2 days of medication). After that, infuse 1 vial (372 mg) through an IV line once daily
- Dosing for capsules: Take 2 capsules (372 mg) of CRESEMBA by mouth every 8 hours for 6 doses (this is the first 2 days of medication). After that, take 2 capsules (372 mg) by mouth once daily
Is it safe for me to take CRESEMBA?
CRESEMBA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:
- Hypersensitivity to CRESEMBA. Coadministration with strong CYP3A4 inhibitors, such as ketoconazole or high-dose ritonavir
- Coadministration with strong CYP3A4 inducers, such as rifampin, carbamazepine, St. John’s wort, or long acting barbiturates
- Use in patients with familial short QT syndrome
CRESEMBA Common Side Effects
Common side effects of CRESEMBA:
- Nausea
- Vomiting
- Diarrhea
- Headache
- Changes to liver blood tests
- Low potassium levels
- Constipation
- Trouble breathing
- Cough
- Swelling of the limbs
- Back pain
CRESEMBA Serious Side Effects
Serious side effects are rare with CRESEMBA. Contact your healthcare provider immediately if you experience any of the following.
- Allergic reactions
- Life-threatening skin reactions
- Liver failure
Effects of other drugs, drug classes and over-the-counter products on CRESEMBA
The following medications may interact with CRESEMBA:
- CYP3A4 inhibitors or inducers may alter the plasma concentrations of isavuconazole
- Appropriate therapeutic drug monitoring and dose adjustment of immunosuppressants (i.e., tacrolimus, sirolimus, and cyclosporine) may be necessary when coadministered with CRESEMBA
- Drugs with a narrow therapeutic window that are P-gp substrates such as digoxin, may require dose adjustment when administered concomitantly with CRESEMBA
Who makes CRESEMBA?
Astellas Pharma
Is CRESEMBA safe in pregnancy?
CRESEMBA may harm your unborn baby. Talk to your healthcare provider if you are pregnant or plan to become pregnant. Women who can become pregnant should use effective birth control while taking CRESEMBA and for 28 days after the last CRESEMBA dose. Talk to your healthcare
provider about birth control methods that may be right for you.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my CRESEMBA prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your CRESEMBA prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient CRESEMBA savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient CRESEMBA savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for CRESEMBA | Canadian Prescription Savings* for CRESEMBA | CRESEMBA Drug Coupon* | CRESEMBA Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of CRESEMBA?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for CRESEMBA | Canadian Prescription Savings* for CRESEMBA | CRESEMBA Drug Coupon* | CRESEMBA Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the CRESEMBA savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the CRESEMBA drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for CRESEMBA, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the CRESEMBA prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, CRESEMBA is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed CRESEMBA for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the CRESEMBA prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the CRESEMBA prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for CRESEMBA
If you are having trouble paying for your CRESEMBA medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for CRESEMBA you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- CRESEMBA is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers CRESEMBA
- If CRESEMBA is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for CRESEMBA
If you are having trouble paying for your CRESEMBA medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for CRESEMBA you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers CRESEMBA
- If CRESEMBA is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for CRESEMBA
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your CRESEMBA treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for CRESEMBA you will need to meet the following criteria:
- You must be currently insured and have coverage for CRESEMBA
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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