canagliflozin/metformin
Used for Type 2 Diabetes
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Manufactured by various FDA-approved generic manufacturers.
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canagliflozin/metformin Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is canagliflozin/metformin available in?
canagliflozin/metformin is available as an extended-release oral tablet that contains:
- Canagliflozin 50 mg and metformin HCl 500 mg
- Canagliflozin 50 mg and metformin HCl 1,000 mg
- Canagliflozin 150 mg and metformin HCl 500 mg
- Canagliflozin 150 mg and metformin HCl 1,000 mg
What is canagliflozin/metformin used for?
canagliflozin/metformin is a SGLT2 inhibitor / Biguanide and is used for the following:
- Type 2 diabetes
- To lower the risk of major heart events (e.g., heart attack, stroke) in adults with Type 2 diabetes and heart disease
- To lower the risk of hospitalization for heart failure, death due to heart problems, and worsening of kidney problems in certain adults with Type 2 diabetes and diabetic kidney disease
How does canagliflozin/metformin work?
canagliflozin/metformin is a combination of two medications that work together to lower blood sugar levels. Canagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It works in the kidneys to lower blood sugar by causing your body to get rid of excess sugar through your urine. Canagliflozin might also improve blood flow through the heart and kidneys by blocking sodium (salt) reabsorption in the kidneys. This might help lower your risk of heart and kidney complications. Metformin is a biguanide. It works by lowering the amount of sugar your liver makes and helps your body respond better to insulin. It also lowers absorption of sugar from your gut.
How do I take canagliflozin/metformin?
- In general, your dose will depend on your current medications — if you’re currently taking either Invokana (canagliflozin), metformin, or both. Your dose will also depend on how well your kidneys are working
- Dosing for people who aren’t currently taking either Invokana (canagliflozin) or metformin is listed below.
- Invokamet: The typical starting dose is 50 mg/500 mg (canagliflozin/metformin) by mouth twice daily with meals
- INVOKAMET XR: The typical starting dose is 100 mg/1,000 mg (canagliflozin/metformin) by mouth once daily with breakfast
- The maximum dose is 300 mg/2,000 mg (canagliflozin/metformin) per day
Is it safe for me to take canagliflozin/metformin?
canagliflozin/metformin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have:
- Severe renal impairment (eGFR less than 30 mL/min/1.73 m2
- Metabolic acidosis, including diabetic ketoacidosis.
- Serious hypersensitivity reaction to canagliflozin or metformin HCl
canagliflozin/metformin Common Side Effects
Common side effects of canagliflozin/metformin:
- Vaginal yeast infection in females
- Urinary tract infections
- More urination
- Male genital yeast or fungal infections
- Diarrhea
canagliflozin/metformin Serious Side Effects
Serious side effects are rare with canagliflozin/metformin. Contact your healthcare provider immediately if you experience any of the following.
- Severe allergic reaction: rash; hives; trouble breathing; swelling of the face, lips, tongue, or throat
- Lactic acid buildup: dizziness, feeling very tired, nausea, stomach pain, unusual muscle pain, feel cold in the hands or feet, slow or irregular heartbeat, fast breathing
- High ketone levels in the blood: nausea, vomiting, stomach pain, tiredness, thirsty, dry mouth, fruity breath, trouble breathing
Effects of other drugs, drug classes and over-the-counter products on canagliflozin/metformin
The following medications may interact with canagliflozin/metformin:
- Carbonic Anhydrase Inhibitors: May increase risk of lactic acidosis
- Consider more frequent monitoring
- Drugs that Reduce Metformin Clearance: May increase risk of lactic acidosis. Consider benefits and risks of concomitant use
- UGT enzyme inducers decrease canagliflozin exposure which may reduce the effectiveness of INVOKAMET XR.
- The risk of hypoglycemia is increased when INVOKANA is used concomitantly with insulin secretagogues (e.g., sulfonylurea) or insulin
- INVOKAMET XR increases digoxin exposure.
- Concomitant use of an SGLT2 inhibitor with lithium may decrease serum lithium concentrations
Who makes canagliflozin/metformin?
Various FDA-approved generic manufacturers
Is canagliflozin/metformin safe in pregnancy?
Based on animal data showing adverse renal effects from canagliflozin, INVOKAMET or INVOKAMET XR is not recommended during the second and third trimesters of pregnancy.
What to do if you missed your canagliflozin/metformin dose
The FDA's medical product safety reporting program for health professionals, patients and consumers.
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Things to know
Can canagliflozin be used with metformin?
Why is canagliflozin not used?
What should you not mix with metformin?
Is canagliflozin better than metformin?
Who should not take canagliflozin?
What is the best medication to pair with metformin?
What is the best diabetic medication to add to metformin?
What are the side effects of canagliflozin?
What happens if you take metformin and Jardiance together?
Does Jardiance work well with metformin?
Should Jardiance be used with metformin?
Should you take metformin and Farxiga together?
What is the difference between metformin and Invokana?
What is the brand name for canagliflozin and metformin hydrochloride?
What is the difference between metformin and canagliflozin?
Is Invokana the same as Jardiance?
What is Jardiance with metformin called?
Is Invokana and Farxiga the same?
What is Farxiga and metformin called?
Is Farxiga and Jardiance the same medication?
Is there a generic for canagliflozin?
What are the three brand name of metformin?
What is the difference between Jardiance and Invokana and Farxiga?
What is the replacement for Invokana?
Can I take Invokana and metformin at the same time?
Should I take Invokana in the morning or at night?
When is the best time to take canagliflozin?
What if I forgot to take my metformin for 3 days?
Are Invokana and Ozempic the same?
What is the best combination of metformin?
Why take Farxiga and metformin together?
What time of day should Invokana be taken?
Is there a better drug for type 2 diabetes than metformin?
Can you lose weight on metformin Invokana?
Why do you lose so much weight on metformin?
Can you lose belly fat with metformin?
How quickly will you lose weight on metformin?
What's the most weight you can lose on metformin?
How much weight can you lose in a month on metformin?
What foods should you avoid while taking metformin?
How much weight can you lose on Ozempic in a month?
Is Ozempic better than metformin for weight loss?
How to lose weight fast on metformin?
What is the diabetic drug that helps you lose weight?
Can you lose too much weight on metformin?
Which is better Ozempic or Invokana?
Which is better Farxiga or Invokana?
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