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Canagliflozin is available as a 100 mg and 300 mg oral tablet.

Canagliflozin is a SGLT2 inhibitor and is used for the following:

• Type 2 diabetes
• Lowering the risk of major heart events (e.g., heart attack, stroke) in adults with Type 2 diabetes and heart disease
• Lowering the risk of hospitalization for heart failure, death due to heart problems, and worsening of kidney problems in certain adults with Type 2 diabetes and diabetic kidney disease

Canagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It works in the kidneys to prevent the absorption of sugar and sodium (salt) back into your body. It lowers blood sugar by causing your body to get rid of excess sugar through your urine. And by preventing sodium reabsorption, the heart fills with blood easier and has an easier time pumping blood throughout the body. This might also improve blood flow through the kidneys and slow the worsening of kidney problems.

• Canagliflozin is typically started at 100 mg by mouth once daily before your first meal of the day. Your provider might raise your dose to 300 mg daily depending on how well the medication is working for you
• Your dose might differ if you have kidney problems. It also might differ if you’re taking certain medications like rifampin (Rifadin), phenytoin (Dilantin), phenobarbital, or ritonavir (Norvir)

Canagliflozin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are on dialysis.

Common side effects of Canagliflozin:

• Vaginal yeast infection in females
• Urinary tract infections
• More urination

Serious side effects are rare with Canagliflozin. Contact your healthcare provider immediately if you experience any of the following.

• Severe allergic reaction: rash; trouble breathing; swelling of the face, lips, tongue, or throat
• High ketone levels in the blood: nausea, vomiting, stomach pain, tiredness, thirsty, dry mouth, fruity breath, trouble breathing

• The following medications may interact with Canagliflozin:
• UGT enzyme inducers decrease Canagliflozin exposure which may reduce the effectiveness of Canagliflozin
• The risk of hypoglycemia is increased when Canagliflozin is used concomitantly with insulin secretagogues (e.g., sulfonylurea) or insulin
• Canagliflozin increases digoxin exposure
• Concomitant use of an SGLT2 inhibitor with lithium may decrease serum lithium concentrations

Various FDA-approved generic manufacturers

Based on animal data showing adverse renal effects from Canagliflozin, INVOKAMET or Canagliflozin is not recommended during the second and third trimesters of pregnancy.

• Invokana