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Cabenuva is the brand name for cabotegravir and rilpivirine and iss available as an intramuscular injection.

Cabenuva is available in a kit that consists of single-dose vials containing:

• 400 mg/2 mL (200 mg/mL) of cabotegravir and 600 mg/2 mL (300 mg/mL) of rilpivirine in an extended-release injectable suspension.
• 600 mg/3 mL (200 mg/mL) of cabotegravir and 900 mg/3 mL (300 mg/mL) of rilpivirine in an extended-release injectable suspension.

Cabenuva is 2 antiretrovirals used as a complete regimen for the treatment of HIV-1 infection in adults and adolescents 12 years of age and older who weigh at least 35 kg.

Cabenuva is a combination of 2 antiretroviral medications:

• Cabotegravir is an integrase strand transfer inhibitor (INSTI). It works by blocking an enzyme (protein) called integrase that HIV uses to insert its genetic material into your cells. This keeps the virus from spreading.
• Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It works by blocking an enzyme called reverse transcriptase, which HIV needs to make copies of itself.

Cabenuva can be given once a month or every other month.

If given once a month:

• The usual starting dose is two injections, 600 mg of cabotegravir and 900 mg of rilpivirine into the buttock muscle for the first month. The maintenance dose will then be 2 separate injections, 400 mg of cabotegravir and 600 mg of rilpivirine given once a month.
• If given every-other-month: The usual starting dose is two injections, 600 mg of cabotegravir and 900 mg of rilpivirine into the buttocks muscle once a month for the first 2 months. The maintenance dose will be the same, given once every other month starting at month 4.

Cabenuva is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Hypersensitivity reaction to cabotegravir or rilpivirine
• Taking certain drugs where significant decreases in cabotegravir and/or rilpivirine concentrations may occur

Common side effects of Cabenuva:

• Injection-site reactions
• Fever
• Fatigue
• Headache
• Bone or muscle pain
• Nausea
• Trouble sleeping
• Dizziness
• Rash
• Stomach pain
• Vomiting
• Diarrhea

Serious side effects are rare with Cabenuva. Contact your healthcare provider immediately if you experience any of the following:

• Serious allergic reactions: rash, mouth sores, feeling ill, trouble breathing, tiredness, fever, muscle or joint pain, swelling in the face, redness or swelling in the eyes
• Liver damage: upper right stomach pain, yellowing of the skin or eyes, dark urine, light-colored stools nausea, vomiting, reduced appetite, itching
• Depression or other mood changes: feeling sad, restlessness, anxiety, suicidal thoughts and behavior

The following medications may interact with Cabenuva:

• Other antiretroviral medications for the treatment of HIV-1 infection are not recommended
• Drugs that induce UGT1A1 or CYP3A4 may decrease the plasma concentrations
• Of the components of Cabenuva
• Cabenuva should be used with caution if used with medications that can cause Torsade de Pointes

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If you are pregnant or planning to get pregnant, talk to your doctor about the risks and benefits of Cabenuva. Thiss medication stays in your body for a long time, and there is limited data on its safety during pregnancy. It’s also recommended that you enroll in a registry to track how this medication affects people in pregnancy.

• Cabotegravir/Rilpivirine