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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

BENLYSTA Uses, Side Effects, Interactions, Warnings & Dosing



BENLYSTA is the brand name for belimumab and is available as injection for subcutaneous and IV use.

What dosages is BENLYSTA available in?

What dosages is BENLYSTA available in?

BENLYSTA is available in strengths of 120 mg and 400 mg for IV use and 200mg/ml for subcutaneous use.

What is BENLYSTA used for?

What is BENLYSTA used for?

BENLYSTA is a biologic and is used to treat the following:

  • Add-on treatment for systemic lupus erythematosus (SLE)
  • Add-on treatment for lupus nephritis (a condition that causes damage to your kidneys)
How does BENLYSTA work?

How does BENLYSTA work?

BENLYSTA is a biologic medication. It lowers inflammation (swelling) by attaching to certain proteins in your immune system, which stops them from turning on.

How do I take BENLYSTA?

How do I take BENLYSTA?

BENLYSTA is typically dosed as follows:

Subcutaneous (SC) injection (for adults 18 years and older only):

  • SLE: The typical dose is 200 mg injected under the skin once per week
  • Lupus nephritis: The typical dose is 400 mg injected under the skin once per week for 4 doses. After 4 doses, the dose will be 200 mg once per week

Intravenous (IV) injection:

  • SLE and lupus nephritis: Dosing will depend on your or your child’s weight. The dose will be prepared and administered by a healthcare provider. The typical dose is 10 mg/kg of body weight injected into your vein every 2 weeks for 3 doses. After 3 doses, the dose will be given every 4 weeks
Is it safe for me to take BENLYSTA?

Is it safe for me to take BENLYSTA?

BENLYSTA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

BENLYSTA Common Side Effects

BENLYSTA Common Side Effects

Common side effects of BENLYSTA:

  • Nausea
  • Diarrhea
  • Fever
  • Common cold
  • Bronchitis
  • Difficulty sleeping
  • Pain in arms or legs
  • Depression
  • Migraine
  • Sore throat
BENLYSTA Serious Side Effects

BENLYSTA Serious Side Effects

Serious side effects are rare with BENLYSTA. Contact your healthcare provider immediately if you experience any of the following.

  • Severe infection: confusion, fever, difficulty breathing, weakness, cough, sweating, chills, stomach pain, diarrhea, burning sensation when you urinate
  • Serious allergic reaction (anaphylaxis): difficulty breathing, hives, itching, fast heartbeat, tightness in the throat, nausea, stomach pain, dizziness, lightheadedness, swelling in the face or tongue
  • Depression and thoughts or behavior related to harming yourself
Effects of other drugs, drug classes and over-the-counter products on BENLYSTA

Effects of other drugs, drug classes and over-the-counter products on BENLYSTA

  • Formal drug interaction studies have not been performed with BENLYSTA. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking
Who makes BENLYSTA?

Who makes BENLYSTA?


Is BENLYSTA safe in pregnancy?

Is BENLYSTA safe in pregnancy?

It is not known if BENLYSTA will harm your unborn baby. You and your doctor will have to decide if you should take BENLYSTA while you are pregnant or if you plan to become pregnant.There is a pregnancy exposure registry that evaluates pregnancy outcomes in women with lupus exposed to BENLYSTA during pregnancy. Healthcare professionals are encouraged to refer patients and pregnant women are encouraged to enroll themselves by calling 1-877-311-8972 or
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What to do if you missed your BENLYSTA dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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