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Benlysta is the brand name for belimumab and is available as injection for subcutaneous and IV use.

Benlysta is available in strengths of 120 mg and 400 mg for IV use and 200mg/ml for subcutaneous use.

Benlysta is a biologic and is used to treat the following:

• Add-on treatment for systemic lupus erythematosus (SLE)
• Add-on treatment for lupus nephritis (a condition that causes damage to your kidneys)

Benlysta is a biologic medication. It lowers inflammation (swelling) by attaching to certain proteins in your immune system, which stops them from turning on.

Benlysta is typically dosed as follows:

Subcutaneous (SC) injection (for adults 18 years and older only):

• SLE: The typical dose is 200 mg injected under the skin once per week
• Lupus nephritis: The typical dose is 400 mg injected under the skin once per week for 4 doses. After 4 doses, the dose will be 200 mg once per week

Intravenous (IV) injection:

• SLE and lupus nephritis: Dosing will depend on your or your child’s weight. The dose will be prepared and administered by a healthcare provider. The typical dose is 10 mg/kg of body weight injected into your vein every 2 weeks for 3 doses. After 3 doses, the dose will be given every 4 weeks

Benlysta is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Benlysta:

• Nausea
• Diarrhea
• Fever
• Common cold
• Bronchitis
• Difficulty sleeping
• Pain in arms or legs
• Depression
• Migraine
• Sore throat

Serious side effects are rare with Benlysta. Contact your healthcare provider immediately if you experience any of the following.

• Severe infection: confusion, fever, difficulty breathing, weakness, cough, sweating, chills, stomach pain, diarrhea, burning sensation when you urinate
• Serious allergic reaction (anaphylaxis): difficulty breathing, hives, itching, fast heartbeat, tightness in the throat, nausea, stomach pain, dizziness, lightheadedness, swelling in the face or tongue
• Depression and thoughts or behavior related to harming yourself

• Formal drug interaction studies have not been performed with Benlysta. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking

GlaxoSmithKline

It is not known if Benlysta will harm your unborn baby. You and your doctor will have to decide if you should take Benlysta while you are pregnant or if you plan to become pregnant.There is a pregnancy exposure registry that evaluates pregnancy outcomes in women with lupus exposed to Benlysta during pregnancy. Healthcare professionals are encouraged to refer patients and pregnant women are encouraged to enroll themselves by calling 1-877-311-8972 or
visiting mother to baby

• Belimumab