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Apixaban is available as a 2.5 mg and 5 mg oral tablet.

Apixaban is an anticoagulant (blood thinner) that is used to:

• Lower the risk of stroke or blood clots in people with nonvalvular atrial fibrillation (AFib)
• Lower the risk of repeat blood clot in the legs or arms (deep vein thrombosis, or DVT), or lungs (pulmonary embolism, or PE)
• Prevent DVT after hip or knee replacement surgery
• Treat DVT and PE

Apixaban is an anticoagulant (blood thinner) known as a direct-acting oral anticoagulant (DOAC). It works by stopping a specific clotting factor called factor Xa from working. By blocking factor Xa, it’ll cause less blood clots to form in your body so you’re less likely to have a stroke, heart attack, or clot in your arms or legs.

Apixaban is typically dosed as follows:

• To lower risk of stroke or clots in AFib: The typical dose is 5 mg by mouth twice daily
• To lower risk of repeat DVT and PE: The typical dose is 2.5 mg by mouth twice daily. You’ll typically start Apixaban after already receiving treatment for your blood clot for at least 6 months
• To prevent DVT after hip or knee surgery: The typical dose is 2.5 mg by mouth twice daily, starting within 24 hours after surgery. Treatment typically lasts about 2 weeks to a month, depending on the type of surgery you had
• To treat DVT and PE: The typical starting dose is 10 mg by mouth twice daily for a week. The typical maintenance dose is 5 mg by mouth twice daily

Apixaban is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Active pathological bleeding
• Severe hypersensitivity to Apixaban

Common side effects of Apixaban:

• Bleeding
• Bruising
• Nosebleeds
• Bleeding gums

Serious side effects are rare with Apixaban. Contact your healthcare provider immediately if you experience any of the following.

• Stroke: sudden numbness or weakness on one side of the body, feeling confused, trouble speaking or understanding speech, dizziness, trouble keeping balance
• Blood clot in the leg or arm: swelling or redness in arms or legs, skin that’s warm to touch
• Blood clot in the lungs: trouble breathing, chest pain, cough, irregular heartbeat
• Severe bleeding: feeling faint, lightheaded, dizziness, vomiting blood, bloody or dark-colored stools, severe stomach pain or discomfort
• Bleeding around spinal cord (after spinal procedures only): pain, tingling, a burning sensation, numbness, weakness, or are unable to urinate

The following medications may interact with Apixaban:

• Combined P-gp and strong CYP3A4 inhibitors increase blood levels of Apixaban
• Reduce Apixaban dose or avoid coadministration.
• Simultaneous use of combined P-gp and strong CYP3A4 inducers reduces blood
• levels of Apixaban: Avoid concomitant use.

Various FDA-approved generic manufacturers

It is not known if Apixaban will harm your unborn baby.
Females who are able to become pregnant:  Talk with your healthcare provider about pregnancy planning during
treatment with Apixaban. Talk with your healthcare provider about your risk of severe uterine bleeding if you are treated
with blood thinner medicines, including Apixaban.

• Eliquis