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Apidra is the brand name for insulin glulisine injection.

Apidra 100 units/mL (U-100) is available as:

• 10 mL vials
• 3 mL cartridge system for use in OptiClik (Insulin Delivery Device)

Apidra is an insulin that is available to treat:

• Type 1 diabetes (adults and children age 4 years and older)
• Type 2 diabetes (adults only)

Apidra is an insulin, which is a natural hormone your body normally makes to lower glucose (sugar) levels in the blood. It helps your body absorb and store sugar from your bloodstream after eating a meal. It also stops your liver from making glucose.

Your healthcare provider will work with you to determine your dose of Apidra. The dose of Apidra will be different for each person. It depends on different factors such as, whether you have type 1 or type 2 diabetes, how well your body responds to insulin, and how you’re receiving this medication. Subcutaneous (SC) injection: Apidra is typically injected under the skin within 15 minutes before a meal or within 20 minutes right after a meal. Continuous insulin pump: Refer to the instructions from your insulin pump manufacturer.

Apidra is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have symptoms of low blood sugar.

Common side effects of Apidra:

• Type 1 diabetes
• Common cold
• Low blood sugar
• Upper respiratory tract infection
• Headache – children only
• Seizure from low blood sugar – children only
• Flu
• Type 2 diabetes
• Upper respiratory tract infection
• Common cold
• Swelling in the hands, ankles, or legs
• Flu
• Joint pain

Serious side effects are rare with Apidra. Contact your healthcare provider immediately if you experience any of the following.

• Severely low blood sugar: dizziness, shakiness, feeling confused, feeling irritable or anxious, feeling faint, sweating, extreme hunger
• Ketoacidosis (high ketone levels in the blood): nausea, vomiting, stomach pain, tiredness, thirsty, dry mouth, fruity breath, trouble breathing
• Severely low potassium levels: weakness, muscle cramps or twitches, constipation, abnormal heartbeat, nausea, vomiting
• Severe allergic reactions: rash, hives, swelling of face, tongue, and throat, difficulty breathing

The following medications may interact with Apidra:

• Certain drugs affect glucose metabolism and may necessitate insulin dose adjustment
• The signs of hypoglycemia may be reduced or absent in patients taking anti-adrenergic drugs (e.g., beta-blockers, clonidine, guanethidine, and reserpine).

sanofi-aventis U.S.

It is not known if Apidra may harm your unborn baby. It is very important to maintain control of your blood sugar
levels during pregnancy. Your healthcare provider will decide which insulin is best for you during your pregnancy.

• Insulin Glulisine