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MEDICAL INFORMATION
Apalutamide Key Facts
What dosages is Apalutamide available in?
Apalutamide is available as a 60 mg and 240 mg oral tablet.
What is Apalutamide used for?
- Apalutamide is an anticancer and is used to treat advanced or metastatic prostate cancer (cancer that’ve spread to other areas)
How does Apalutamide work?
Apalutamide is an androgen receptor inhibitor (antiandrogen), a type of hormone therapy that works by blocking testosterone from binding to prostate cancer cells. Without testosterone, cancer cells won’t have the fuel they need to grow or spread.
How do I take Apalutamide?
- Apalutamide is typically dosed at 240 mg taken by mouth once a day
Is it safe for me to take Apalutamide?
Apalutamide is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
Apalutamide Common Side Effects
Common side effects of Apalutamide:
- Tiredness
- Rash
- Hot flashes
- Diarrhea
- Nausea
- Headaches, changes to your vision, and other symptoms of high blood pressure
- Joint pain
- Falls
- Weight loss
Apalutamide Serious Side Effects
Serious side effects are rare with Apalutamide. Contact your healthcare provider immediately if you experience any of the following.
- Seizures
- Heart problems: chest pain, racing heartbeat, shortness of breath, arm or shoulder pain, swelling of your legs or feet, sudden weight gain, sweating, fatigue, dizziness, nausea or
- vomiting
- Stroke: sudden numbness or weakness, confusion, trouble speaking, trouble seeing, dizziness, severe headache
Effects of other drugs, drug classes and over-the-counter products on Apalutamide
The following medications may interact with Apalutamide:
- Concomitant use with medications that are sensitive substrates of CYP3A4
- CYP2C19, CYP2C9, UGT, P-gp, BCRP, or OATP1B1 may result in loss of activity of these medications
Who makes Apalutamide?
Various FDA-approved generic manufacturers
Is Apalutamide safe in pregnancy?
Based on findings from animals and its mechanism of action, Apalutamide can cause fetal harm and loss of pregnancy when administered to a pregnant female. If you are a male with a female partner of reproductive potential you should use effective contraception during treatment and for 3 months after the last dose of Apalutamide.
What is the brand name for Apalutamide?
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Experienced a Side Effect?
Report to Yellow Card (UK) or MedWatch (US)
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We are a broad skilled and passionate group of clinicians with experience of operating in health systems in the United Kingdom & United States. Providing excellent care and advice is at the heart of everything we do. You can read more about our medical team by visiting the medical team page or learn more about how we curate content by visiting our editorial process
DeLon Canterbury
US Board Certified Pharmacist/PGX & Deprescribing Specialist
Daniel Cheung
Pharmacist Independent Prescriber, Pharmacist
Aseel Hamoud Bedan
Hospital Consultant
Ketan Patel
Pharmacist Independent Prescriber, Pharmacist
Ihtesham Sabri
Medical Director
Rajive Patel
Medical Writer
Amish Patel
Pharmacist Independent Prescriber, Superintendant Pharmacist, Pharmacist
Stefano Mirabello
Pharmacist Independent Prescriber, Clinical Safety Officer (CSO), Pharmacist
Navin Khosla
UK Responsible Person (UKRP), Pharmacist Independent Prescriber, Clinical Safety Officer (CSO), Pharmacist
Jamie Winn
US Board Certified Pharmacist
Monica Khosla
Medical Writer