AFINITOR
Used for Cancer
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Manufactured by Novartis Pharmaceuticals
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
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AFINITOR Uses, Side Effects, Interactions, Warnings & Dosing
What is AFINITOR?
AFINITOR is the brand name for everolimus and is available as oral tablet.
What dosages is AFINITOR available in?
AFINITOR is available as a 2.5 mg, 5 mg, 7.5 mg, and 10 mg oral tablet.
What is AFINITOR used for?
AFINITOR is a kinase inhibitor that is used to treat:
Breast cancer (hormone receptor-positive, HER2-negative)
Neuroendocrine tumors (NET)
Kidney cancer (renal cell cancer or RCC)
Tuberous sclerosis complex (TSC)-associated kidney tumor
Tuberous sclerosis complex (TSC)-associated brain tumor (people age 1 years and older)
Tuberous sclerosis complex (TSC)-associated seizures (people age 2 years and older)
How does AFINITOR work?
AFINITOR is kinase inhibitor. It blocks a specific type of protein that’s involved in cell growth and spread. This protein can be more active in cancer cells, leading to tumor growth. When it blocks this protein, cancer cells can’t grow and spread as well.
How do I take AFINITOR?
AFINITOR is dosed as follows:
Breast cancer, neuroendocrine tumors, kidney cancer, or TSC-associated kidney tumor
AFINITOR and generic everolimus tablet only: The typical dose is 10 mg by mouth once daily.
TSC-associated brain tumor
AFINITOR, Afinitor Disperz, and generic everolimus tablet: Your provider will determine your dose base on your body surface area (BSA, in units of m2), which takes into account your body weight and height. The typical starting dose is 4.5 mg/m2 by mouth once daily.
TSC-associated seizures
Afinitor Disperz only: Your provider will determine your dose base on your body surface area (BSA, in units of m2), which takes into account your body weight and height. The typical starting dose is 5 mg/m2 by mouth once daily.
Is it safe for me to take AFINITOR?
AFINITOR is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a clinically significant hypersensitivity to everolimus or to other rapamycin derivatives.
AFINITOR Common Side Effects
Common side effects of AFINITOR:
- Abnormal blood cell counts
- Higher cholesterol and lipid levels
- Mouth ulcers or inflammation
- Higher blood sugar levels
- Abnormal liver labs
- Rash
- Diarrhea
- Abnormal kidney lab values
- Infections
- Extreme tiredness
- Fluid buildup in the arms or legs
- Stomach pain
- Nausea
- Fever
- Appetite loss
- Headache
- Cough
- Weight loss
AFINITOR Serious Side Effects
Serious side effects are rare with AFINITOR. Contact your healthcare provider immediately if you experience any of the following.
Serious infections: repeated fevers, chills, cough, trouble breathing, severe diarrhea, vomiting, painful or frequent urination
Serious bleeds: bleeding or bruising that doesn’t stop or go away, large amount of bleeding, throwing up blood, bloody or black and tarry stool
Lung problems: new or worsening cough, chest pain, difficulty breathing
Serious allergic reactions: throat tightness, trouble breathing, flushing, swelling, chest pain
Angioedema: Swelling of the face, lips, throat
Effects of other drugs, drug classes and over-the-counter products on AFINITOR
The following medications may interact with AFINITOR:
- P-gp and strong CYP3A4 inhibitors: Avoid concomitant use.
- P-gp and moderate CYP3A4 inhibitors: Reduce the dose as recommended.
- P-gp and strong CYP3A4 inducers: Increase the dose as recommended.
Who makes AFINITOR?
Novartis Pharmaceuticals
Is AFINITOR safe in pregnancy?
AFINITOR or AFINITOR DISPERZ can cause harm to your unborn baby.
Females who are able to become pregnant:
Your healthcare provider will give you a pregnancy test before you start treatment with AFINITOR or AFINITOR DISPERZ.
You should use effective birth control during treatment and for 8 weeks after your last dose of AFINITOR or AFINITOR DISPERZ.
Males with a female partner, you should use effective birth control during treatment and for 4 weeks after your last dose of AFINITOR or AFINITOR DISPERZ.
Talk to your healthcare provider about birth control methods that may be right for you during this time. If you become pregnant or think you are pregnant, tell your healthcare provider right away.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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