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Advate is the brand name for antihemophilic factor and is available as an intravenous injection.

Advate is available as a lyophilized powder in single-dose vials containing nominally 250, 500, 1000, 1500, 2000, 3000, or 4000 IU.

Advate is a clotting factor us to to treat or prevent bleeding in people with hemophilia A.

Advate is a clotting factor replacement for people who are missing special blood-clotting proteins called factor VIII (FVIII) due to hemophilia A. By replacing the missing clotting factor in people who naturally don’t have it, bleeding episodes can be reduced or treated.

The typical dose ranges from 20 to 40 International Units (IU)/kg of body weight given IV every other day.

Advate is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in those who have life-threatening hypersensitivity reactions, including anaphylaxis, to mouse or hamster protein or other constituents of the product (mannitol, trehalose, sodium chloride, histidine, Tris, calcium chloride, polysorbate 80, and/or glutathione).

Common side effects of Advate:

• Fever
• Headache
• Cough
• Common cold symptoms

Serious side effects are rare with Advate. Contact your healthcare provider immediately if you experience any of the following:

• Serious allergic reaction (anaphylaxis): difficulty breathing, hives, itching, fast heartbeat, nausea, stomach pain, dizziness, lightheadedness, swelling in the face or tongue
• Development of antibodies against FVIII

There are no major drug interactions listed for Advate. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Takeda Pharmaceuticals

It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Antihemophilic Factor