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Abraxane is the brand name for paclitaxel protein-bound particles that are available as an IV infusion.

Abraxane contains 100 mg of
paclitaxel formulated as albumin-bound particles.

Abraxane is a microtubule inhibitor that is used to treat:
Locally advanced or metastatic NSCLC, together with platinum-based chemotherapy
Metastatic pancreatic cancer, along with gemcitabine (Gemzar)
Metastatic breast cancer, after previous therapy has stopped working

Abraxane works by stopping cells from growing and dividing. This medication interferes with substances in cells in your body called microtubules, which are important for maintaining cell structure and normal functioning. By doing so, Abraxane prevents fast growing cells (like tumor cells) from spreading.

Abraxane consists of albumin (a protein normally found in your body) attached to paclitaxel. This albumin-bound formulation of paclitaxel lowers the risk of infusion-related reactions that’s common for people receiving paclitaxel (Taxol), the version that’s not albumin-bound.

Your provider will determine your dose of Abraxane based on your body surface area (BSA) in units of m2, which takes into consideration height and weight. Your dose will be infused through the veins (IV) by a healthcare provider.

NSCLC: The typical dose is 100 mg/m2 infused IV on days 1, 8, and 15 of each 21-day cycle.

Metastatic pancreatic cancer: The typical dose is 125 mg/m2 infused IV on days 1, 8, and 15 of each 28-day cycle.

Metastatic breast cancer: The typical dose is 260 mg/m2 infused IV once every 3 weeks.

Your dose of Abraxane might be different if you’ve liver problems or if you experience serious side effects.

Abraxane is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:
Neutrophil counts of < 1,500 cells/mm3. Severe hypersensitivity reactions to ABRAXANE.

Common side effects of Abraxane:

• Low blood cell counts
• Feeling very tired
• Nausea
• Numbness or tingling
• Hair loss
• Swelling in the ankles and feet
• Diarrhea
• Fever
• Vomiting
• Not feeling hungry
• Rash

Serious side effects are rare with Abraxane. Contact your healthcare provider immediately if you experience any of the following.

Lower blood cell counts: unusual bleeding or bruising, fever
Severe infections: fever, trouble catching your breath, pain in the abdomen
Serious allergic reactions: swelling of the face, lips, or tongue, difficulty swallowing, rash, itching, trouble breathing
Lung inflammation: cough, trouble catching your breath

The following medications may interact with Abraxane:

• Use caution when concomitantly administering Abraxane with inhibitors or inducers of
• either CYP2C8 or CYP3A4.

Bristol-Myers Squibb

Abraxane can harm your unborn baby.
Females who are able to become pregnant: 
Your healthcare provider will check to see if you are pregnant before you start treatment with Abraxane.
You should not become pregnant during your treatment and for at least six months after the last dose of Abraxane.
You should use effective birth control (contraception) during your treatment and for at least six months after the last dose of Abraxane. Talk to your healthcare provider about birth control methods you can use during this time.

Males with a female sexual partner who can become pregnant: 
Abraxane can harm the unborn baby of your partner.
You should not father a child during your treatment and for at least three months after the last dose of Abraxane.
You should use effective birth control (contraception) during your treatment and for at least three months after the last dose of Abraxane.

• Paclitaxel Protein-Bound Particles (Albumin-Bound)