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ABRAXANE

ABRAXANE

Used for Cancer

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Manufactured by Bristol-Myers Squibb

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

ABRAXANE Uses, Side Effects, Interactions, Warnings & Dosing

What is ABRAXANE?

What is ABRAXANE?

ABRAXANE is the brand name for paclitaxel protein-bound particles that are available as an IV infusion.

What dosages is ABRAXANE available in?

What dosages is ABRAXANE available in?

ABRAXANE contains 100 mg of
paclitaxel formulated as albumin-bound particles.

What is ABRAXANE used for?

What is ABRAXANE used for?

ABRAXANE is a microtubule inhibitor that is used to treat:
Locally advanced or metastatic NSCLC, together with platinum-based chemotherapy
Metastatic pancreatic cancer, along with gemcitabine (Gemzar)
Metastatic breast cancer, after previous therapy has stopped working

How does ABRAXANE work?

How does ABRAXANE work?

ABRAXANE works by stopping cells from growing and dividing. This medication interferes with substances in cells in your body called microtubules, which are important for maintaining cell structure and normal functioning. By doing so, ABRAXANE prevents fast growing cells (like tumor cells) from spreading.

ABRAXANE consists of albumin (a protein normally found in your body) attached to paclitaxel. This albumin-bound formulation of paclitaxel lowers the risk of infusion-related reactions that’s common for people receiving paclitaxel (Taxol), the version that’s not albumin-bound.

How do I take ABRAXANE?

How do I take ABRAXANE?

Your provider will determine your dose of ABRAXANE based on your body surface area (BSA) in units of m2, which takes into consideration height and weight. Your dose will be infused through the veins (IV) by a healthcare provider.

NSCLC: The typical dose is 100 mg/m2 infused IV on days 1, 8, and 15 of each 21-day cycle.

Metastatic pancreatic cancer: The typical dose is 125 mg/m2 infused IV on days 1, 8, and 15 of each 28-day cycle.

Metastatic breast cancer: The typical dose is 260 mg/m2 infused IV once every 3 weeks.

Your dose of ABRAXANE might be different if you’ve liver problems or if you experience serious side effects.

Is it safe for me to take ABRAXANE?

Is it safe for me to take ABRAXANE?

ABRAXANE is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:
Neutrophil counts of < 1,500 cells/mm3. Severe hypersensitivity reactions to ABRAXANE.

ABRAXANE Common Side Effects

ABRAXANE Common Side Effects

Common side effects of ABRAXANE:

  • Low blood cell counts
  • Feeling very tired
  • Nausea
  • Numbness or tingling
  • Hair loss
  • Swelling in the ankles and feet
  • Diarrhea
  • Fever
  • Vomiting
  • Not feeling hungry
  • Rash
ABRAXANE Serious Side Effects

ABRAXANE Serious Side Effects

Serious side effects are rare with ABRAXANE. Contact your healthcare provider immediately if you experience any of the following.

Lower blood cell counts: unusual bleeding or bruising, fever
Severe infections: fever, trouble catching your breath, pain in the abdomen
Serious allergic reactions: swelling of the face, lips, or tongue, difficulty swallowing, rash, itching, trouble breathing
Lung inflammation: cough, trouble catching your breath

Effects of other drugs, drug classes and over-the-counter products on ABRAXANE

Effects of other drugs, drug classes and over-the-counter products on ABRAXANE

The following medications may interact with ABRAXANE:

  • Use caution when concomitantly administering ABRAXANE with inhibitors or inducers of
  • either CYP2C8 or CYP3A4.
Who makes ABRAXANE?

Who makes ABRAXANE?

Bristol-Myers Squibb

Is ABRAXANE safe in pregnancy?

Is ABRAXANE safe in pregnancy?

ABRAXANE can harm your unborn baby.
Females who are able to become pregnant: 
Your healthcare provider will check to see if you are pregnant before you start treatment with ABRAXANE.
You should not become pregnant during your treatment and for at least six months after the last dose of ABRAXANE.
You should use effective birth control (contraception) during your treatment and for at least six months after the last dose of ABRAXANE. Talk to your healthcare provider about birth control methods you can use during this time.

Males with a female sexual partner who can become pregnant: 
ABRAXANE can harm the unborn baby of your partner.
You should not father a child during your treatment and for at least three months after the last dose of ABRAXANE.
You should use effective birth control (contraception) during your treatment and for at least three months after the last dose of ABRAXANE.

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What to do if you missed your ABRAXANE dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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