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Tysabri is the brand name for natalizumab and is available as an intravenous solution.

Tysabri is available as a 300 mg/15 mL (20 mg/mL) solution in a single-dose vial for dilution prior to infusion.

Tysabri is a type of monoclonal antibody that treats relapsing forms of multiple sclerosis (MS) and moderate-to-severe Crohn’s disease (CD) in adults.

Tysabri is an integrin antagonist. It’s not completely understood how Tysabri works. But it’s thought to work by attaching to a protein on immune cells called integrin. As a consequence, it blocks signals in your body that cause inflammation. This helps block inflammation from affecting your nerves (for MS) or your gut (for CD).

The typical dose of Tysabri is 300 mg infused by a healthcare professional into the vein (IV) once per month.

Tysabri is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Patients who have or have had PML
• Patients who have had a hypersensitivity reaction to Tysabri

Common side effects of Tysabri:

• Headache
• Fatiguee
• Urinary tract infection
• Joint pain
• Depression
• Lower respiratory tract infection
• Pain in arm or leg
• Rash or other skin irritation

Serious side effects are rare with Tysabri. Contact your healthcare provider immediately if you experience any of the following:

• Serious brain infection: weakness on one side of the body, clumsiness, confusion, changes in personality, changes in vision, difficulty remembering, difficulty thinking, headache, stiff neck, light sensitivity, seizures
• Other infection: fever, difficulty breathing, cough, stomach pain, diarrhea, sweating, weakness, chills
• Liver damage: nausea, vomiting, pain in the upper right side of the stomach, poor appetite, dark urine, yellowing of the skin or whites of your eyes
• Allergic reaction or infusion reaction: hives, rash, itching, dizziness, fever, shaking, nausea, flushing, difficulty breathing, tightness in the throat, chest pain

The following medications may interact with Tysabri:

• Other immunosuppressants (e.g., 6-
• Mercaptopurine, azathioprine, cyclosporine, or methotrexate) or TNF-blockers
• Corticosteroids

Biogen, Inc.

Tysabri may cause low platelets (thrombocytopenia) and low red blood cells (anemia) in your newborn baby if you take it while you are pregnant. Notify your doctor if you become pregnant or if you have plans on becoming pregnant while taking Tysabri.

• Natalizumab