glasdegib
Used for Cancer
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Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
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glasdegib Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is glasdegib available in?
glasdegib is available as a 25 mg and 100 mg oral tablet.
What is glasdegib used for?
glasdegib is a hedgehog pathway inhibitor and is used for the following:
- Newly-diagnosed acute myeloid leukemia (AML), given with low-dose cytarabine (Ara-C) chemotherapy, in:
- Adults who are 75 years of age or older
- Adults who have other health problems that prevent them from receiving intensive chemotherapy
How does glasdegib work?
glasdegib is a Hedgehog pathway inhibitor. By blocking the Hedgehog pathway, the medication slows cancer growth. Blocking the pathway also helps prevent drug resistance and allows other leukemia medications like cytarabine (Ara-C) to work better. When glasdegib is used with cytarabine, the two medications work together to fight the cancer.
How do I take glasdegib?
glasdegib is typically dosed at 100 mg by mouth once a day. glasdegib is taken every day during each 28-day treatment cycle. glasdegib is taken together with a low dose of a chemotherapy medication called cytarabine, which is given as an injection on days 1 to 10 of the 28-day treatment cycle.00 mg by mouth once a day. glasdegib is taken every day during each 28-day treatment cycle. glasdegibis taken together with a low dose of a chemotherapy medication called cytarabine, which is given as an injection on days 1 to 10 of the 28-day treatment cycle.
Is it safe for me to take glasdegib?
glasdegib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
glasdegib Common Side Effects
Common side effects of glasdegib:
- Higher blood creatinine levels
- Changes in electrolyte levels in blood
- Anemia
- Bleeding
- Tiredness
- Neutropenic fever
- Low platelet count
- Swelling
- Muscle, joint, or bone pain
- Nausea
- Higher liver enzyme levels in blood cell count
- Trouble breathing
- Lower appetite
- Taste changes
- Mouth sores
- Rash
- Constipation
glasdegib Serious Side Effects
Serious side effects are rare with glasdegib. Contact your healthcare provider immediately if you experience any of the following.
- Changes in heart rhythm: lightheadedness, irregular heartbeat, blurry vision, fainting, loss of consciousness, seizures
Effects of other drugs, drug classes and over-the-counter products on glasdegib
The following medications may interact with glasdegib:
- Strong CYP3A4 Inhibitors: Consider alternative therapies that are not strong CYP3A4 inhibitors or monitor for increased risk of adverse reactions, including QTc interval prolongation
- Strong CYP3A4 Inducers: Avoid concomitant use with glasdegib
- Moderate CYP3A4 Inducers: Avoid concomitant use with glasdegib. If, concomitant use cannot be avoided, increase the dose of glasdegib
- QTc Prolonging Drugs: Avoid co-administration with glasdegib. If co-administration is unavoidable, monitor for increased risk of QTc interval prolongation
Who makes glasdegib?
Various FDA-approved generic manufacturers
Is glasdegib safe in pregnancy?
glasdegib can cause fetal harm when administered to a pregnant woman. Conduct pregnancy testing in females of reproductive potential within 7 days prior to initiating therapy with glasdegib. Advise females of reproductive potential to use effective contraception during treatment with glasdegib and at least 30 days after the last dose. Males should use effective contraception, including a condom, even after a vasectomy, to avoid drug exposure to a pregnant partner or a female partner of reproductive potential during treatment with glasdegib and for at least 30 days after the last dose. Advise males to not donate semen during treatment with glasdegib for at least 30 days after the last dose.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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