Diltiazem Generic

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Diltiazem HCl Extended Release (ER)
    Generic for Cardizem CD
    30 extended release capsules $5.7 USD
    Save $22.50
  3. Diltiazem HCl Extended Release (ER)
    Generic for Cardizem CD
    30 extended release capsules $6.6 USD
    Save $21.60
  4. Diltiazem HCl Extended Release (ER)
    Generic for Cardizem CD
    30 extended release capsules $7.2 USD
    Save $21.00
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Do you need a prescription for diltiazem?

Yes, diltiazem is only available with a valid physician Rx.

How much is diltiazem without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase diltiazem, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for diltiazem in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a diltiazem savings card?

Yes. Save up to 90% on your diltiazem with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a diltiazem coupon provider in the US?

No. Now Patient does not provide diltiazem coupons or FREE diltiazem samples.

Do you accept commercial, Medicare or Medicaid coverage for diltiazem in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much diltiazem?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using diltiazem. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much diltiazem. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic diltiazem?

Generic diltiazem refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of diltiazem

Diltiazem is approved by the U.S. Food and Drug Administration (FDA) for the treatment of hypertension (high blood pressure), angina (chest pain), and certain heart rhythm disorders.

Active ingredient of diltiazem

The active ingredient of diltiazem is diltiazem hydrochloride.

US brand name of diltiazem and manufacturer

Diltiazem is available in the US under various brand names, including Cardizem CD, Cardizem LA, Taztia XT and Tiazac. The manufacturer may vary depending on the brand name.

UK brand name of diltiazem and manufacturer

In the UK, diltiazem is available under various brand names, including Adizem and Dilzem. The manufacturer may vary depending on the brand name.

Prescription requirement for diltiazem

A prescription (Rx) is required for diltiazem in both the US and the UK.

Availability of diltiazem in the UK with NHS prescription

Diltiazem is available in the UK with an NHS prescription.

Conditions treated by diltiazem

Diltiazem is used for the treatment of hypertension (high blood pressure), angina (chest pain), and certain arrhythmias (abnormal heart rhythm disorders), such as atrial fibrillation.
In addition to its cardiovascular benefits, diltiazem can also be used off-label for other conditions such as migraines, Raynaud’s phenomenon, and certain types of dermatological conditions.

How does diltiazem work?

Diltiazem is a medication that belongs to a class of drugs called calcium channel blockers. It works by blocking the movement of calcium into the cells of the heart and blood vessels. Calcium plays a crucial role in regulating the contraction and relaxation of smooth muscles, including those in the walls of blood vessels and the heart.
By inhibiting calcium from entering the cells, diltiazem helps to relax and widen blood vessels, allowing for easier blood flow. This results in a decrease in blood pressure as the heart doesn’t have to work as hard to pump blood through the relaxed vessels.
Additionally, diltiazem also affects the electrical conduction within the heart. It slows the rate at which electrical impulses travel through the heart, specifically in the atrioventricular (AV) node. This can be beneficial in treating certain heart rhythm disorders, as it helps to regulate the heart’s rhythm and prevent rapid or irregular heartbeats.

Forms of diltiazem available

Diltiazem is available in various forms, including immediate-release tablets, extended-release tablets, and injectable solutions.

Dosage of diltiazem

The dosage of diltiazem may vary depending on the individual’s specific condition, response to treatment, and other factors. It is essential to follow the recommended dosage instructions provided by the healthcare provider. Dosing varies depending on formulation and use.
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Directions for diltiazem use

Diltiazem should be taken exactly as directed by the healthcare provider. The tablets are usually taken orally, with or without food. It is important to take diltiazem consistently and at the same time each day for the best results.
Store at room temperature away from moisture, heat, and light.

Warnings and precautions for diltiazem

  • Diltiazem may have certain risks and potential side effects. Discussing these with a healthcare provider before starting the medication is important. Inform your healthcare provider about medical conditions such as kidney disease, liver disease, or congestive heart failure
  • Individuals who have had a previous allergic reaction to diltiazem or any other calcium channel blockers should avoid using this medication. Allergic reactions may range from mild skin rashes to severe symptoms like trouble breathing and swelling of the face, lips, or tongue
  • Diltiazem should not be used in individuals with certain severe heart conditions such as sick sinus syndrome or those with a resting heart rate below 50 beats per minute. These conditions can be worsened by the use of diltiazem and can lead to serious complications
  • Diltiazem is contraindicated in individuals who have recently experienced a heart attack (acute myocardial infarction). Using diltiazem in such cases may further compromise heart function and increase the risk of adverse cardiac events
  • Individuals with low blood pressure (hypotension) should exercise caution when using diltiazem. This medication can lower blood pressure even further, which may lead to symptoms like dizziness, lightheadedness, and fainting. It is important to monitor blood pressure regularly and adjust the dosage of diltiazem if necessary
  • Diltiazem is metabolized in the liver and excreted by the kidneys. Therefore, individuals with severe liver or kidney impairment should use diltiazem with caution or avoid it altogether. These conditions can affect the metabolism and excretion of the medication, leading to an increased risk of adverse effects. Signs of liver problems include dark urine, tiredness, decreased appetite, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin
  • It is important to inform a healthcare professional about all your prescription drugs, including over-the-counter drugs, supplements, and herbal products, as they may interact with diltiazem

Drug interactions

Diltiazem can interact with several medications, including:

  • Combining diltiazem with beta-blockers, such as metoprolol or propranolol, can also result in a significant drop in blood pressure or heart rate. This combination should be used with caution and under close medical supervision. Your doctor may need to adjust the dosages of these medications to minimize the risk of side effects
  • Concurrent use of diltiazem with other antiarrhythmic drugs may increase the risk of abnormal heart rhythms
  • Diltiazem can increase the levels of digoxin in the blood, which may lead to toxicity
  • Combining diltiazem with certain statin drugs may increase the risk of muscle-related side effects
  • Diltiazem may increase the levels of cyclosporine in the blood, potentially leading to toxicity
  • Diltiazem can enhance the effects of benzodiazepines, such as sedation and drowsiness
  • Consuming grapefruit or grapefruit juice while taking diltiazem can increase the levels of the medication in the blood, potentially resulting in an increased risk of side effects

Use of diltiazem if pregnant or planning pregnancy

The use of diltiazem during pregnancy and breastfeeding should be discussed with a healthcare provider. It is generally not recommended for use during pregnancy unless the potential benefits outweigh the risks.

Possible side effects of diltiazem

Common side effects of diltiazem may include dizziness, headache, constipation, flushing, and low blood pressure. Serious side effects are rare but can occur, these include an overly slow heart beat (bradycardia), heart failure, liver problems, and allergic reactions. Promptly report any concerning symptoms to a healthcare provider.

Similar drugs to diltiazem

Other calcium channel blockers, such as verapamil and amlodipine may be used as alternatives for the treatment of hypertension and certain heart conditions.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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