diltiazem
Used for Hypertension and Unstable Angina
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Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
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diltiazem Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is diltiazem available in?
diltiazem is available as a 120 mg, 180 mg, 240 mg, and 300 mg extended-release oral capsule.
What is diltiazem used for?
diltiazem is a calcium channel blocker (CCB) used for high blood pressure and chest pain.
How does diltiazem work?
diltiazem is a calcium channel blocker. It works by slowing your heart rate and relaxing your blood vessels to lower your blood pressure. This also helps your heart to get more oxygen so it doesn’t need to work as hard to pump, which can help with chest pain.
How do I take diltiazem?
diltiazem is typically taken by mouth once daily.
Is it safe for me to take diltiazem?
diltiazem is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have sick sinus syndrome except in the presence of a
functioning ventricular pacemaker, second- or third-degree AV block except in
the presence of a functioning ventricular pacemaker, hypotension (less than 90 mm Hg systolic), or acute myocardial infarction and pulmonary congestion documented by x-ray on admission.
diltiazem Common Side Effects
Common side effects of diltiazem include:
- Headache
- Dizziness
- Low heart rate
- Swelling
- Rash
- Diarrhea
- Palpitations (racing heart)
- Nervousness
- Cough
- Muscle aches
- Weakness
diltiazem Serious Side Effects
Serious side effects are rare with diltiazem. Contact your healthcare provider immediately if you experience any of the following. Liver problems: severe nausea, vomiting, right-sided stomach pain, fatigue, low or no appetite, yellowing of the skin or eyes Serious allergic and skin reactions: sore throat, fever, fatigue, rash, hives, painful blisters, skin reddening, skin peeling, swollen lymph nodes Heart failure: chest pain, difficulty breathing, dizziness, tiredness, swollen legs and feet, bloating
Effects of other drugs, drug classes and over-the-counter products on diltiazem
The following medications may interact with diltiazem:
- Anesthetics – When used concomitantly, anesthetics and calcium blockers should be titrated carefully
- Benzodiazepines – Studies showed that taking these medications together can result inincreased clinical effects (e.g., prolonged sedation) of both midazolam and triazolam
- Buspirone – diltiazem may significantly cause enhanced effects and increased toxicity of buspirone
- Carbamazepine – Concomitant administration of diltiazem with carbamazepine has been reported to result in elevated serum levels of carbamazepine (40% to 72% increase), resulting in toxicity in some cases
- Clonidine – Sinus bradycardia resulting in hospitalization and pacemaker insertion has been reported in association with the use of clonidine concurrently with diltiazem
- Cyclosporine – In renal and cardiac transplant recipients, a reduction of cyclosporine dose ranging from 15% to 48% was necessary to maintain cyclosporine trough concentrations similar to those seen prior to the addition of diltiazem
- Digitalis – Administration of diltiazem with digoxin may increase plasma digoxin. It is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing diltiazem therapy to avoid possible over- or underdigitalization
- Quinidine – Monitoring for quinidine adverse effects may be warranted and the dose adjusted accordingly
- Rifampin – Coadministration of rifampin with diltiazem lowered the diltiazem plasma concentrations to undetectable levels. Coadministration of diltiazem with rifampin or any known CYP3A4 inducer should be avoided when possible, and alternative therapy considered
- Statins – Diltiazem is an inhibitor of CYP3A4 and has been shown to increase significantly the levels of some statins
Who makes diltiazem?
Various FDA-approved generic manufacturers
Is diltiazem safe in pregnancy?
It is not known if diltiazem will harm your unborn baby. If you become pregnant while receiving diltiazem, talk to your healthcare provider.
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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