Used for Cancer

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Manufactured by various FDA-approved generic manufacturers.

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axitinib Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is axitinib available in?

What dosages is axitinib available in?

axitinib is available as a 1 mg and 5 mg oral tablet.

What is axitinib used for?

What is axitinib used for?

axitinib is a VEGFR inhibitor and is used for the following:
Kidney cancer that has spread or cannot be removed by surgery
First treatment option, used together with Bavencio (avelumab) or Keytruda (pembrolizumab) Second treatment option when a different therapy previously didn’t work, used by itself

How does axitinib work?

How does axitinib work?

axitinib is a type of targeted anticancer therapy known as a tyrosine kinase inhibitor (TKI). More specifically, it’s considered a VEGFR inhibitor. This medication targets and blocks VEGFR proteins in cancer cells that are involved in providing blood supply to the tumor. By blocking these proteins, axitinib (axitinib) prevents blood vessels from forming and supplying blood to the tumor. This helps to slow and stop cancer growth.

How do I take axitinib?

How do I take axitinib?

axitinib is typically started at 5 mg by mouth twice daily (about 12 hours apart), with or without food. Your provider will adjust your dose based on how well the medication is working to treat your cancer, the severity of any side effects, and whether you have liver problems.

Is it safe for me to take axitinib?

Is it safe for me to take axitinib?

axitinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

axitinib Common Side Effects

axitinib Common Side Effects

Common side effects of axitinib:

  • Diarrhea
  • High blood pressure
  • Tiredness
  • Less appetite
  • Nausea
  • Hoarseness
  • Hand-foot skin reaction
  • Weight loss
  • Vomiting
  • Weakness
  • Constipation
axitinib Serious Side Effects

axitinib Serious Side Effects

Serious side effects are rare with axitinib. Contact your healthcare provider immediately if you experience any of the following.

  • Dangerously high blood pressure: headache, confusion, blurry vision, chest pain, nausea, vomiting
  • Blood clot in the lungs: cough, chest pain, trouble breathing, racing heart
  • Blood clot in the leg: leg cramp, swelling, pain, muscle tightness
  • Stroke: sudden numbness or weakness in the arm, leg, or face; confusion; headache; trouble seeing or walking
  • Heart problems (e.g., heart attack, heart failure): shortness of breath, chest pain, sweating, weakness, tiredness, dizziness, nausea, swelling in feet and legs, sudden weight gain
  • Serious bleeding: unusual bleeding, bleeding that’s difficult to stop, easy bruising, blood in urine or stool, black or tarry stool, vomiting blood, stomach cramps
  • Tears in the gut: fever, chills, intense stomach pain or cramps, bloating, vomiting blood, red or black stool
Effects of other drugs, drug classes and over-the-counter products on axitinib

Effects of other drugs, drug classes and over-the-counter products on axitinib

The following medications may interact with axitinib:

  • Avoid strong CYP3A4/5 inhibitors. If unavoidable, reduce the axitinib dose
  • Avoid strong CYP3A4/5 inducers
Who makes axitinib?

Who makes axitinib?

Various FDA-approved generic manufacturers

Is axitinib safe in pregnancy?

Is axitinib safe in pregnancy?

Taking axitinib during pregnancy can harm your unborn baby. You should not become pregnant during treatment with axitinib. are able to become pregnant. You should have a pregnancy test before you start treatment with axitinib. Use effective birth control during treatment and for 1 week after your last dose of axitinib. Talk to your healthcare provider about birth control methods that you can use to prevent pregnancy during this time.


What to do if you missed your axitinib dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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