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Axitinib is available as a 1 mg and 5 mg oral tablet.

Axitinib is a VEGFR inhibitor and is used for the following:
Kidney cancer that has spread or cannot be removed by surgery
First treatment option, used together with Bavencio (avelumab) or Keytruda (pembrolizumab) Second treatment option when a different therapy previously didn’t work, used by itself

Axitinib is a type of targeted anticancer therapy known as a tyrosine kinase inhibitor (TKI). More specifically, it’s considered a VEGFR inhibitor. This medication targets and blocks VEGFR proteins in cancer cells that are involved in providing blood supply to the tumor. By blocking these proteins, Axitinib prevents blood vessels from forming and supplying blood to the tumor. This helps to slow and stop cancer growth.

Axitinib is typically started at 5 mg by mouth twice daily (about 12 hours apart), with or without food. Your provider will adjust your dose based on how well the medication is working to treat your cancer, the severity of any side effects, and whether you have liver problems.

Axitinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Axitinib:

• Diarrhea
• High blood pressure
• Tiredness
• Less appetite
• Nausea
• Hoarseness
• Hand-foot skin reaction
• Weight loss
• Vomiting
• Weakness
• Constipation

Serious side effects are rare with Axitinib. Contact your healthcare provider immediately if you experience any of the following.

• Dangerously high blood pressure: headache, confusion, blurry vision, chest pain, nausea, vomiting
• Blood clot in the lungs: cough, chest pain, trouble breathing, racing heart
• Blood clot in the leg: leg cramp, swelling, pain, muscle tightness
• Stroke: sudden numbness or weakness in the arm, leg, or face; confusion; headache; trouble seeing or walking
• Heart problems (e.g., heart attack, heart failure): shortness of breath, chest pain, sweating, weakness, tiredness, dizziness, nausea, swelling in feet and legs, sudden weight gain
• Serious bleeding: unusual bleeding, bleeding that’s difficult to stop, easy bruising, blood in urine or stool, black or tarry stool, vomiting blood, stomach cramps
• Tears in the gut: fever, chills, intense stomach pain or cramps, bloating, vomiting blood, red or black stool

The following medications may interact with Axitinib:

• Avoid strong CYP3A4/5 inhibitors. If unavoidable, reduce the Axitinib dose
• Avoid strong CYP3A4/5 inducers

Various FDA-approved generic manufacturers

Taking Axitinib during pregnancy can harm your unborn baby. You should not become pregnant during treatment with Axitinib. are able to become pregnant. You should have a pregnancy test before you start treatment with Axitinib. Use effective birth control during treatment and for 1 week after your last dose of Axitinib. Talk to your healthcare provider about birth control methods that you can use to prevent pregnancy during this time.

• Inlyta