Buy Estriol online with free consultation & prescription
Book a quick face-to-face video consultation with a UK certified prescribing pharmacist, nurse, or doctor. If approved, your Estriol will be prescribed* and delivered straight to your door with next working day tracked delivery†. Avoid GP waiting lists. No delays. Just expert care.
Estriol is indicated for the treatment of Menopause.
*Includes Free Private Prescription & Consultation.
†Applies to UK only.
Manufactured by Marlborough Pharma.

Estriol doses and pack sizes

Estriol
Estriol doses and pack sizes
*Your clinician will recommend the right strength and quantity for you during the consultation.
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Estriol prices
| Brand/Generic | Form | Dosage | Quantity | Price | Delivery Cost | Consultation Cost |
|---|---|---|---|---|---|---|
| EstriolBrand | Cream | 0.01% | 80 grams | £54.90 | £0.00*(with Core+ Plan) | £0.00 |
FAQs
Answers to popular questions about Estriol
What is Estriol?
Estriol (oestriol) is a weak, naturally occurring oestrogen used topically to treat vulvovaginal atrophy (also called genitourinary syndrome of menopause, GSM). It is available as a vaginal cream (e.g., Ovestin, Blissel) and pessaries. Estriol acts locally on the vaginal and urethral tissues and has minimal systemic absorption, making it very safe for long-term use. It does not require the addition of a progestogen even in women with an intact uterus when used vaginally at recommended doses.
How does Estriol work?
Estriol restores oestrogen to the vaginal and urethral tissues, reversing the thinning, dryness, and fragility caused by declining oestrogen levels after menopause. It increases vaginal lubrication, restores normal vaginal pH (reducing infections), strengthens the vaginal epithelium, and can improve urinary symptoms such as urgency and recurrent UTIs. Because systemic absorption is minimal at topical doses, it does not carry the risks associated with systemic HRT.
Do I need a prescription for Estriol?
In the UK, estriol vaginal cream is available on prescription (e.g., Ovestin). A lower-strength product, Blissel Gel (50 mcg estriol per dose), has been reclassified for pharmacy sale and can be purchased without a prescription from pharmacists after a consultation. Standard-strength estriol cream (1 mg/g) remains prescription-only.
How do I use Estriol vaginal cream?
Insert one application of cream (0.5 g containing 0.5 mg estriol) into the vagina at bedtime using the applicator provided. Use daily for the first 2–3 weeks (initial treatment phase), then reduce to twice weekly for maintenance. Wash the applicator after each use. You may also apply a small amount externally to the vulva if needed. Always follow your prescriber’s specific instructions.
How long does Estriol take to work?
Most women notice improvement in vaginal dryness, itching, and discomfort within 2–3 weeks of starting estriol. Full benefit, including improvement in urinary symptoms and recurrent UTIs, may take 4–12 weeks. Estriol is intended for long-term use — symptoms will return if treatment is stopped.
What are the side effects of Estriol?
Side effects are uncommon because systemic absorption is minimal. Local irritation, burning, or itching may occur when first starting treatment, usually settling within a few days. Vaginal spotting may occur initially. Breast tenderness and headache are rare with topical estriol. Long-term vaginal estriol use is not associated with increased breast cancer or cardiovascular risk.
Do I need progestogen with vaginal Estriol?
No, vaginal estriol at standard doses does not require the addition of a progestogen, even in women with an intact uterus. NICE, BMS, and FSRH guidance confirm that the systemic absorption is too low to stimulate the endometrium. This makes it a very safe option for long-term management of vaginal atrophy.
Can I use Estriol alongside systemic HRT?
Yes, vaginal estriol can be used alongside systemic HRT (tablets, patches, gels) if systemic HRT alone does not adequately relieve vaginal symptoms. Many women need local vaginal oestrogen in addition to their systemic HRT.
How can I get Estriol?
Estriol cream is available on NHS prescription from your GP or through NowPatient. Blissel Gel (lower strength) is available over the counter from pharmacies. NowPatient offers online consultations and home delivery for prescription-strength estriol products.
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