Buy Colofac online with free consultation & prescription
Book a quick face-to-face video consultation with a UK certified prescribing pharmacist, nurse, or doctor. If approved, your Colofac will be prescribed* and delivered straight to your door with next working day tracked delivery†. Avoid GP waiting lists. No delays. Just expert care.
Colofac is indicated for the treatment of Irritable Bowel Syndrome (IBS).
*Includes Free Private Prescription & Consultation.
†Applies to UK only.
Manufactured by Mylan.
Colofac doses and pack sizes
Colofac
Colofac doses and pack sizes
*Your clinician will recommend the right strength and quantity for you during the consultation.
Treatment£21.89
Shipping£5.94
Total if approved£27.83
How it works
Order online
Colofac prices
| Brand/Generic | Form | Dosage | Quantity | Price | Delivery Cost | Consultation Cost |
|---|---|---|---|---|---|---|
| ColofacBrand | Tablets | 135mg | 100 | £21.89 | £0.00*(with Core+ Plan) | £0.00 |
Similar treatments
Alternative Irritable Bowel Syndrome (IBS) treatments
FAQs
Answers to popular questions about Colofac
What is Colofac?
Colofac is the brand name for mebeverine hydrochloride, an antispasmodic medication used to treat the symptoms of irritable bowel syndrome (IBS) and other conditions involving gut spasms. It is available as Colofac 135 mg tablets and Colofac MR 200 mg (modified-release) capsules. Colofac IBS (135 mg) is available over the counter from pharmacies for adults aged 18 and over with a confirmed diagnosis of IBS. Higher-dose and modified-release formulations require a prescription.
How does Colofac work?
Mebeverine works directly on the smooth muscle of the gut, reducing spasms and relaxing the intestinal wall. It has a direct musculotropic action, meaning it acts on the muscle cells themselves rather than through the nervous system. This makes it different from anticholinergic antispasmodics. Mebeverine helps relieve the cramping, pain, and bloating associated with IBS without affecting normal gut motility or causing the anticholinergic side effects (dry mouth, blurred vision) associated with some other antispasmodics.
Is Colofac available over the counter?
Yes, Colofac IBS 135 mg tablets are available over the counter from pharmacies for adults aged 18 and over who have been previously diagnosed with IBS by a doctor. The pharmacist will confirm your diagnosis before supply. Colofac MR 200 mg capsules require a prescription. Generic mebeverine is also available on NHS prescription and is usually less expensive than the branded product.
How do I take Colofac?
For Colofac 135 mg tablets: take one tablet three times daily, approximately 20 minutes before meals. Swallow whole with water. For Colofac MR 200 mg capsules: take one capsule twice daily, 20 minutes before the two main meals of the day. Do not chew or crush MR capsules. Taking Colofac before meals helps it work when the gut is most active. Continue treatment for as long as symptoms persist.
How long does Colofac take to work?
Some patients notice improvement within a few days of starting Colofac, but it may take 2–4 weeks of regular use for the full benefit. If there is no improvement after 2 weeks of consistent use, consult your doctor. For best results, take Colofac regularly before meals rather than only when symptoms occur. Dietary modifications alongside Colofac often improve outcomes.
What are the side effects of Colofac?
Colofac has an excellent safety profile and side effects are rare. Occasional side effects include allergic skin reactions (rash, urticaria), and very rarely angioedema. Unlike anticholinergic antispasmodics, mebeverine does not cause dry mouth, blurred vision, constipation, or urinary retention. It does not cause drowsiness and does not affect driving ability. This favourable side effect profile makes it one of the most commonly recommended antispasmodics for IBS.
Can I take Colofac during pregnancy?
There is limited clinical data on mebeverine in pregnancy. It is generally avoided during pregnancy unless the prescriber considers the benefit outweighs the risk. If you are pregnant or planning to become pregnant, discuss IBS management options with your doctor. Dietary and lifestyle changes are preferred first-line approaches for IBS during pregnancy.
Can I take Colofac with other IBS treatments?
Yes, Colofac can be used alongside other IBS treatments including fibre supplements (such as ispaghula husk), peppermint oil capsules, loperamide (for diarrhoea-predominant IBS), laxatives (for constipation-predominant IBS), and low-dose antidepressants prescribed for IBS pain. It can also be used alongside the low-FODMAP diet. Discuss a comprehensive management plan with your GP.
How can I get Colofac?
Colofac IBS 135 mg is available OTC from pharmacies with a previous IBS diagnosis. Colofac MR and generic mebeverine are available on NHS prescription from your GP or online services like NowPatient. NowPatient offers online consultations for IBS management.
Related articles
Your health shouldn’t wait.
Consultations, prescriptions, medication delivery, health monitoring – all in one place.
Rated excellent on Trustpilot
Meet our medical team
We are a broad skilled and passionate group of clinicians with experience of operating in regulated health systems in the United Kingdom & United States. Providing excellent care and advice is at the heart of everything we do.
