Buy Epiduo online with free consultation & prescription
Book a quick face-to-face video consultation with a UK certified prescribing pharmacist, nurse, or doctor. If approved, your Epiduo will be prescribed* and delivered straight to your door with next working day tracked delivery†. Avoid GP waiting lists. No delays. Just expert care.
Epiduo is indicated for the treatment of Acne.
*Includes Free Private Prescription & Consultation.
†Applies to UK only.
Manufactured by Galderma.

Epiduo doses and pack sizes

Epiduo
Epiduo doses and pack sizes
*Your clinician will recommend the right strength and quantity for you during the consultation.
How it works
Similar treatments
Epiduo alternatives
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Epiduo prices
| Brand/Generic | Form | Dosage | Quantity | Price | Delivery Cost | Consultation Cost |
|---|---|---|---|---|---|---|
| EpiduoBrand | Gel | 0.1%/2.5% | 60 grams | £39.99 | £0.00*(with Core+ Plan) | £0.00 |
| EpiduoBrand | Gel | 0.3%/2.5% | 60 grams | £39.99 | £0.00*(with Core+ Plan) | £0.00 |
FAQs
Answers to popular questions about Epiduo
What is Epiduo gel?
Epiduo is a prescription-only topical gel used to treat acne vulgaris in adults and adolescents aged 9 years and over. It contains two active ingredients: adapalene 0.1% (a topical retinoid) and benzoyl peroxide 2.5%. Epiduo is applied once daily and addresses multiple acne mechanisms — unblocking pores, reducing inflammation, and killing acne-causing bacteria. A stronger formulation, Epiduo Forte (adapalene 0.3%/benzoyl peroxide 2.5%), is also available for more severe acne. Epiduo is manufactured by Galderma.
How does Epiduo work?
Epiduo works through two complementary mechanisms. Adapalene is a retinoid that normalises skin cell turnover inside pores, preventing the formation of comedones (blocked pores) and reducing inflammation. Benzoyl peroxide is an antibacterial agent that kills Cutibacterium acnes through oxidative action — importantly, bacteria cannot develop resistance to it. The combination of a retinoid and benzoyl peroxide is considered one of the most effective topical acne treatments and is recommended as a first-line option in many acne guidelines including NICE.
Is Epiduo better than Differin?
Epiduo contains adapalene (the same retinoid in Differin) plus benzoyl peroxide. Studies show that the combination in Epiduo is more effective than either adapalene or benzoyl peroxide alone. If you have inflammatory acne with both blackheads/whiteheads and red spots, Epiduo provides broader coverage. Differin (adapalene alone) may be preferred for primarily comedonal acne or for those with very sensitive skin who cannot tolerate benzoyl peroxide. Your prescriber can advise which is most appropriate.
How do I apply Epiduo gel?
Apply a thin layer of Epiduo gel once daily in the evening to clean, dry skin. Use a pea-sized amount for the whole face. Spread it evenly over the entire acne-prone area, not just individual spots. Avoid the eyes, lips, and mucous membranes. Wash your hands after application. If you have sensitive skin, start by applying every other evening for the first 1–2 weeks, then increase to nightly use as your skin adjusts. Follow with a non-comedogenic moisturiser if needed.
How long does Epiduo take to work?
Epiduo typically begins to show results within 2–4 weeks, though an initial temporary worsening of acne may occur in the first 2–4 weeks (a retinoid ‘purge’) as adapalene increases skin cell turnover. Significant improvement is usually seen by 8–12 weeks. Full results may take up to 16 weeks with consistent daily use. If you see no improvement after 12 weeks, consult your prescriber about adjusting treatment.
What are the common side effects of Epiduo?
Common side effects include skin dryness, redness (erythema), peeling (desquamation), and a burning or stinging sensation, particularly during the first 2–4 weeks. These are expected retinoid effects and usually settle as the skin adapts. Benzoyl peroxide can also bleach coloured fabrics and hair. Sun sensitivity is increased, so daily use of SPF 30+ sunscreen is essential. Using a gentle cleanser and non-comedogenic moisturiser helps manage irritation. If irritation is severe, reduce frequency of application.
Does Epiduo bleach clothes?
Yes, the benzoyl peroxide in Epiduo can bleach or permanently discolour coloured fabrics, towels, bedding, and hair. Apply Epiduo in the evening and allow it to dry fully before contact with fabrics. Use white or old pillowcases and towels. This bleaching effect occurs with all benzoyl peroxide products and is irreversible.
Can I use Epiduo during pregnancy?
Epiduo should not be used during pregnancy. Adapalene is a retinoid, and retinoids are associated with a risk of birth defects. If you are pregnant, planning to become pregnant, or breastfeeding, stop using Epiduo and inform your doctor. Safe topical alternatives for acne in pregnancy include benzoyl peroxide alone and azelaic acid. Use effective contraception while using Epiduo.
Can I use Epiduo with other acne products?
Be cautious when combining Epiduo with other active skincare products. Avoid using additional retinoids, benzoyl peroxide products, or strong exfoliants (glycolic acid, salicylic acid) at the same time as this can cause excessive irritation. Epiduo can be used alongside an oral antibiotic (such as lymecycline or doxycycline) if prescribed by your doctor. Use a gentle, non-comedogenic cleanser and moisturiser, and always apply sunscreen during the day.
How can I get a prescription for Epiduo?
Epiduo is available on NHS prescription from your GP or dermatologist, or privately through online services like NowPatient. It is commonly prescribed as a first-line topical treatment for mild to moderate acne with both comedonal and inflammatory components. NowPatient provides an online consultation with a qualified UK prescriber who can assess your acne and prescribe Epiduo with home delivery.
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