Icosapent ethyl

Icosapent ethylPrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Icosapent Ethyl 1g
    Generic for Vascepa
    30 capsules $37.5 USD
    Save $290.70
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Do you need a prescription for icosapent ethyl?

Yes, icosapent ethyl is only available with a valid physician Rx.

How much is icosapent ethyl without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase icosapent ethyl, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for icosapent ethyl in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a icosapent ethyl savings card?

Yes. Save up to 90% on your icosapent ethyl with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a icosapent ethyl coupon provider in the US?

No. Now Patient does not provide icosapent ethyl coupons or FREE icosapent ethyl samples.

Do you accept commercial, Medicare or Medicaid coverage for icosapent ethyl in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much icosapent ethyl?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using icosapent ethyl. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much icosapent ethyl. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic icosapent ethyl?

Generic icosapent ethyl refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of icosapent ethyl

Icosapent ethyl is approved by the U.S. Food and Drug Administration (FDA) as an adjunct to diet for reducing triglyceride levels in adults with severe hypertriglyceridemia.

Active ingredient of icosapent ethyl

The active ingredient of icosapent ethyl is icosapent ethyl.

US brand name of icosapent ethyl and manufacturer

Icosapent ethyl is available in the US under the brand name Vascepa. It is manufactured by Amarin Pharma.

UK brand name of icosapent ethyl and manufacturer

In the UK, icosapent ethyl is not currently available as a licensed medication.

Prescription requirement for icosapent ethyl

A prescription (Rx) is required for icosapent ethyl in the US.

Availability of icosapent ethyl in the UK with NHS prescription

Icosapent ethyl is not currently available in the UK.

Conditions treated by icosapent ethyl

Icosapent ethyl is primarily used for the treatment of severe hypertriglyceridemia, which is characterized by high levels of triglycerides in the blood. Icosapent ethyl, commonly known as IPE, is a prescription medication that is used to reduce high levels of triglycerides in the blood. It is a highly purified form of omega-3 fatty acid called eicosapentaenoic acid (EPA). Icosapent ethyl is specifically indicated for individuals who have very high triglyceride levels (≥500 mg/dL) and are at risk of developing pancreatitis.

This medicine is also used together with a statin (cholesterol medicine) to lower the risk of heart attack, stroke, and certain heart problems requiring hospitalization in adults with heart or blood vessel disease or diabetes.

Mechanism of action of icosapent ethyl

Icosapent ethyl is a prescription medication used to treat high levels of triglycerides in the blood. Triglycerides are a type of fat found in the blood that, when elevated, can contribute to the development of cardiovascular diseases such as heart attacks and strokes.

Icosapent ethyl belongs to a class of medications called omega-3 fatty acids. Omega-3 fatty acids are essential nutrients that are primarily obtained through diet, particularly from oily fish such as salmon, mackerel, and sardines. However, in some cases, dietary intake alone may not be sufficient to lower triglyceride levels to a healthy range. This is where medications like icosapent ethyl can be beneficial.

Icosapent ethyl works by reducing the production of triglycerides in the liver and increasing the breakdown of existing triglycerides. By doing so, it helps to lower triglyceride levels and decrease the risk of cardiovascular events.

Forms of icosapent ethyl available

Icosapent ethyl is available in the form of oral capsules.

Dosage of icosapent ethyl

The dosage of icosapent ethyl is typically 4 grams per day, taken as two capsules twice daily with meals. It is important to follow the recommended dosage instructions and patient information provided by the healthcare provider. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Directions for icosapent ethyl use

Icosapent ethyl should be taken exactly as directed by the healthcare provider. Swallow the capsules whole; do not split, chew, crush, or dissolve them. It is important to take icosapent ethyl consistently and continue the prescribed treatment course. Store at room temperature away from moisture and heat.

Warnings and precautions for icosapent ethyl

  • Icosapent ethyl may interact with certain medications, including anticoagulants and antiplatelet drugs. Inform the healthcare provider about all medications being taken
  • If you have had an allergic reaction to icosapent or any of its components in the past, it’s important to avoid using this medication
  • Special caution should be taken with people who have fish and shellfish allergies
  • Icosapent ethyl is derived from fish oil and may lead to a deficiency in vitamin E. Vitamin E is essential for various bodily functions, and its deficiency can cause problems such as muscle weakness, vision problems, and impaired immune function. Your healthcare provider may recommend vitamin E supplementation to prevent or correct any deficiency
  • Some clinical trials have suggested a possible link between omega-3 fatty acid supplementation and an increased risk of atrial fibrillation. However, more research is needed to establish a definitive association
  • Lipid and triglyceride levels should be monitored prior to and periodically during therapy

Drug interactions

  • Icosapent may increase the risk of bleeding when taken concurrently with anticoagulant medications such as warfarin, rivaroxaban or apixaban. These medications are commonly used to prevent blood clots. Combining icosapent with anticoagulants can potentially lead to excessive bleeding or bruising. Therefore, it is crucial to inform your healthcare provider if you are taking any anticoagulant medication before starting icosapent
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin, ibuprofen, and naproxen, are commonly used to reduce pain and inflammation. However, combining these medications with icosapent can increase the risk of bleeding, especially in the gastrointestinal tract. If you are already taking NSAIDs for any medical condition, it is important to inform your healthcare provider before starting icosapent to assess the potential risks and benefits
  • Icosapent is a type of omega-3 fatty acid, and taking additional omega-3 fatty acid supplements alongside it may increase the risk of bleeding. It is recommended to avoid taking any other omega-3 fatty acid supplements while on icosapent unless specifically advised by your healthcare provider
  • Statins are a class of medication commonly used to lower cholesterol levels. When taken alongside icosapent, there is a potential risk of muscle-related side effects, such as muscle pain or weakness. It is important to discuss with your healthcare provider if you are taking any statin therapy before starting icosapent to determine the best course of action for your health
  • Icosapent may affect blood sugar levels and the effectiveness of certain diabetes mellitus medications. It is crucial to inform your healthcare provider if you are taking any medications for diabetes, such as insulin or oral hypoglycemic agents. Your healthcare provider can monitor your blood sugar levels closely and make any necessary adjustments to your diabetes treatment plan if you start taking icosapent

Before starting icosapent or any new medication, it is essential to consult with a healthcare professional. They will have a comprehensive understanding of your medical history, current medications, and potential adverse effects. Inform your healthcare provider about all the prescription drugs you are currently taking, including over-the-counter drugs, supplements, and herbal remedies. This will enable them to make informed decisions and provide appropriate guidance.

Use of icosapent ethyl during pregnancy

The use of icosapent ethyl during pregnancy should be carefully considered, and the potential risks and benefits should be discussed with a healthcare provider.

Use of icosapent ethyl while breastfeeding

It is not known whether icosapent ethyl passes into breast milk. The use of icosapent ethyl while breastfeeding should be discussed with a healthcare provider.

Possible side effects of icosapent ethyl

Common side effects of icosapent ethyl may include joint pain, constipation, muscle pain, and rash. Serious side effects such as heart rhythm problems (atrial fibrillation and atrial flutter) are rare but can occur. Promptly report any concerning symptoms to a healthcare provider.

Similar drugs to icosapent ethyl

Other omega-3 fatty acid derivatives used for the treatment of high triglyceride levels include omega-3-acid ethyl esters and omega-3-carboxylic acids.


Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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