DivalproexPrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Divalproex Sodium Delayed Release (DR)
    Generic for Depakote DR
    60 delayed release tablets $5.7 USD
    Save $39.30
  3. Divalproex Sodium Delayed Release (DR)
    Generic for Depakote DR
    30 delayed release tablets $4.5 USD
    Save $18.00
  4. Divalproex Sodium Delayed Release (DR)
    Generic for Depakote DR
    30 delayed release tablets $4.2 USD
    Save $18.30
  5. Divalproex Sodium Delayed Release (DR)
    Generic for Depakote DR
    90 delayed release capsules $9 USD
    Save $58.50
  6. Divalproex Sodium Extended Release (ER)
    Generic for Depakote ER
    30 extended release tablets $6 USD
    Save $5.10
  7. Divalproex Sodium Extended Release (ER)
    Generic for Depakote ER
    30 extended release tablets $7.2 USD
    Save $3.90
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Do you need a prescription for divalproex?

Yes, divalproex is only available with a valid physician Rx.

How much is divalproex without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase divalproex, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for divalproex in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a divalproex savings card?

Yes. Save up to 90% on your divalproex with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a divalproex coupon provider in the US?

No. Now Patient does not provide divalproex coupons or FREE divalproex samples.

Do you accept commercial, Medicare or Medicaid coverage for divalproex in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much divalproex?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using divalproex. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much divalproex. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic divalproex?

Generic divalproex refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of divalproex

Divalproex is approved by the U.S. Food and Drug Administration (FDA) for various indications, including the treatment of epilepsy, bipolar disorder, and migraine headaches.

Active ingredient of divalproex

The active ingredient of divalproex is divalproex sodium.

US brand name of divalproex and manufacturer

Divalproex is available in the US under various brand names, including Depakote and Depakote ER. The manufacturers may vary depending on the brand names.

UK brand name of divalproex and manufacturer

In the UK, divalproex is available under various brand names, including Epilim and Episenta. The manufacturer may vary depending on the brand name.

Prescription requirement for divalproex

A prescription (Rx) is required for divalproex in both the US and the UK.

Availability of divalproex in the UK with NHS prescription

Divalproex is available in the UK with an NHS prescription.

Conditions treated by divalproex

Divalproex is a medication that is primarily used to treat epilepsy and manic episodes associated with bipolar disorder. It is also sometimes prescribed for the prevention of migraine headaches.
In epilepsy, divalproex helps to control seizures by stabilizing electrical activity in the brain. It can be used alone or in combination with other anti-seizure medications to effectively manage epilepsy in adults and children.
For bipolar disorder, divalproex is used to help stabilize mood and prevent manic episodes. It works by regulating the levels of certain neurotransmitters in the brain, which helps to reduce symptoms such as excessive energy, reckless behavior, and irritability. Divalproex can also be used in combination with other medications for the treatment of bipolar disorder.
Additionally, divalproex can be prescribed as a preventive measure for migraine headaches. It is believed to work by reducing the frequency and severity of migraines, possibly by affecting the neurotransmitters involved in the pain pathways.

How does divalproex work?

Divalproex is also known as sodium valproate and valproic acid. This medicine is an anticonvulsant that works in the brain tissue to stop seizures by targeting and regulating the levels of certain chemicals in the brain.
Specifically, divalproex acts on gamma-aminobutyric acid (GABA), a neurotransmitter that helps to inhibit the overactivity of brain cells. By increasing the levels of GABA in the brain, divalproex helps to calm and stabilize electrical activity, which is particularly useful in treating conditions like epilepsy where there is abnormal and excessive electrical signaling in the brain.
Furthermore, divalproex also modulates the levels of other neurotransmitters such as serotonin and dopamine, which play a crucial role in mood regulation. By affecting these neurotransmitters, divalproex can help to reduce the frequency and severity of manic and depressive episodes associated with bipolar disorder.

It is important to note that the exact mechanism of action of divalproex is not fully understood, and there may be other factors contributing to its therapeutic effects. Additionally, the response to divalproex may vary from person to person, and it is important to work closely with a healthcare professional to determine the most appropriate dosage and treatment plan.

Forms of divalproex available

Divalproex is available in the following dosage forms; oral tablets, extended-release tablets, and oral capsules.

Dosage of divalproex

The dosage of divalproex may vary depending on the specific condition being treated, the severity of the condition, and other individual factors. It is important to follow the recommended dosage instructions and medication guide provided by the healthcare provider.
If you miss a dose it’s important to take the missed dose as soon as you remember. However, if it’s already close to the time for your next dose, it’s best to skip the missed dose and continue with your regular dosing schedule. Taking a double dose to make up for the missed one is not recommended as it can increase the risk of side effects.

Directions for divalproex use

Divalproex should be taken or administered as directed by the healthcare provider. The specific instructions may include the timing of administration, dosage adjustments, and any necessary precautions.
Store at room temperature away from moisture and heat.

Warnings and precautions for divalproex

  • Divalproex may cause serious side effects, including liver problems, pancreatitis, and birth defects if used during pregnancy. It is important to discuss the potential risks and benefits with a healthcare provider
  • You should not use divalproex if you have certain medical conditions such as urea cycle disorders, Alpers-Huttenlocher syndrome (mitochondrial disorder) and liver disease
  • It is important to inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements. They can evaluate the potential adverse effects and make necessary adjustments to your treatment plan to ensure the safety and effectiveness of the medications

Drug interactions of divalproex 

  • Divalproex can interact with certain antidepressants such as selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs). This combination may increase the risk of serotonin syndrome, a potentially life-threatening condition characterized by symptoms like confusion, rapid heart rate, high blood pressure, and tremors
  • Divalproex can intensify the effects of anticoagulant medications like warfarin, increasing the risk of bleeding. Regular monitoring of blood clotting parameters is important if these drugs are used together
  • Concurrent use of divalproex and aspirin may increase the level of valproic acid in the blood, leading to potential side effects. Close monitoring for signs of toxicity, such as drowsiness, dizziness, or tremors, is advised
  • Combining divalproex with other antiepileptic drugs may increase the risk of side effects, such as drowsiness, dizziness, or liver problems. Close monitoring may be necessary when using these drugs together
  • Divalproex can enhance the effects of benzodiazepines, leading to increased sedation and drowsiness. This combination should be used with caution and close monitoring is recommended
  • Divalproex may increase the levels of certain antipsychotic medications in the blood, potentially increasing the risk of side effects. Dose adjustments may be necessary when using these drugs together
  • Divalproex can decrease the effectiveness of oral contraceptives, increasing the risk of unintended pregnancy. Alternative or additional contraceptive methods may be needed while taking divalproex
  • Co-administration of divalproex and lamotrigine can increase the levels of lamotrigine in the blood, potentially leading to side effects. Dose adjustments may be necessary to avoid toxicity

Use of divalproex if pregnant or planning pregnancy

Divalproex can cause an increased risk of birth defects and developmental disorders. It should not be used during pregnancy or breastfeeding unless there are no other suitable treatment options available. Women of childbearing age should use effective contraception (birth control) while taking divalproex.

Possible side effects of divalproex

Common side effects of divalproex may include:

  • Nausea, vomiting, loss of appetite, diarrhea, constipation and  abdominal pain are among the most frequently reported side effects. These symptoms can usually be managed by taking the medication with food or by dividing the dosage throughout the day
  • Divalproex has been linked to weight gain, which may be a concern for some individuals, particularly those already struggling with weight management. It is important to maintain a healthy diet and exercise regularly while taking this medication
  • Divalproex can cause drowsiness or sedation, especially when first starting the medication or when the dosage is increased. It is advisable to avoid activities that require alertness, such as driving or operating heavy machinery, until you know how the medication affects you
  • Divalproex can affect mood and may cause mood swings, irritability, suicidal thoughts and depression in some individuals. It is important to monitor your mood while taking this medication and report any significant changes to your healthcare provider
  • Some individuals may experience hair loss or thinning while taking divalproex. This side effect is generally reversible once the medication is discontinued, but it is important to discuss any concerns with your healthcare provider
  • Divalproex can cause tremors or shaking in some individuals. This side effect may be more common at higher doses or with long-term use of the medication. If tremors become bothersome or interfere with daily activities, it is important to notify your healthcare provider.
  • Divalproex can cause liver damage in rare cases. It is important to have regular liver function tests while taking this medication, especially in the first six months of treatment. If you experience symptoms such as yellowing of the skin or eyes, dark urine, or persistent nausea and tiredness, it is important to seek medical attention
  • Rarely, divalproex can cause inflammation of the pancreas, known as pancreatitis. Symptoms may include severe stomach pain, nausea, and vomiting. Prompt medical attention is necessary if these symptoms occur

Serious side effects are rare but can occur. It is important to promptly report any concerning symptoms to a healthcare provider.

Similar drugs to divalproex

Other antiepileptic medications, such as carbamazepine and lamotrigine, may be used as alternatives to divalproex for the treatment of epilepsy. For bipolar disorder and migraines, other mood stabilizers and migraine-specific medications may be considered.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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